An Update on African Swine Fever Virology

Animal diseases constitute a continuing threat to animal health, food safety, national economy, and the environment. Among those, African swine fever (ASF) is one of the most devastating viruses affecting pigs and wild suids due to the lack of vaccine or effective treatment. ASF is endemic in countr...

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Autores: Karger, Axel, Pérez-Núñez, Daniel, Urquiza, Jesús, Hinojar, Patricia, Alonso Martí, Covadonga, Freitas, Ferdinando B., Revilla Novella, Yolanda, Potier, Marie-Frédérique le, Montoya, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/191382
Acceso en línea:http://hdl.handle.net/10261/191382
Access Level:acceso abierto
Palabra clave:African swine fever virus
Virology
Proteomics
Virus-host interaction
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spelling An Update on African Swine Fever VirologyKarger, AxelPérez-Núñez, DanielUrquiza, JesúsHinojar, PatriciaAlonso Martí, CovadongaFreitas, Ferdinando B.Revilla Novella, YolandaPotier, Marie-Frédérique leMontoya, MaríaAfrican swine fever virusVirologyProteomicsVirus-host interactionAnimal diseases constitute a continuing threat to animal health, food safety, national economy, and the environment. Among those, African swine fever (ASF) is one of the most devastating viruses affecting pigs and wild suids due to the lack of vaccine or effective treatment. ASF is endemic in countries in sub-Saharan Africa, but since its introduction to the Caucasus region in 2007, a highly virulent strain of ASF virus (ASFV) has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. Given the importance of this disease, this review will highlight recent discoveries in basic virology with special focus on proteomic analysis, replication cycle, and some recent data on genes involved in cycle progression and viral–host interactions, such as I215L (E2 ubiquitin-conjugating enzyme), EP402R (CD2v), A104R (histone-like protein), QP509L, and Q706L (RNA helicases) or P1192R (Topoisomerase II). Taking into consideration the large DNA genome of ASFV and its complex interactions with the host, more studies and new approaches are to be taken to understand the basic virus–host interaction for ASFV. Proteomic studies are just paving the way for future research.This paper is based upon work from COST ACTION CA15116 ASF-STOP, supported by COST (European Cooperation in Science and Technology).Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean Cooperation in Science and TechnologyConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/191382reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/v11090864Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1913822026-05-22T06:33:51Z
dc.title.none.fl_str_mv An Update on African Swine Fever Virology
title An Update on African Swine Fever Virology
spellingShingle An Update on African Swine Fever Virology
Karger, Axel
African swine fever virus
Virology
Proteomics
Virus-host interaction
title_short An Update on African Swine Fever Virology
title_full An Update on African Swine Fever Virology
title_fullStr An Update on African Swine Fever Virology
title_full_unstemmed An Update on African Swine Fever Virology
title_sort An Update on African Swine Fever Virology
dc.creator.none.fl_str_mv Karger, Axel
Pérez-Núñez, Daniel
Urquiza, Jesús
Hinojar, Patricia
Alonso Martí, Covadonga
Freitas, Ferdinando B.
Revilla Novella, Yolanda
Potier, Marie-Frédérique le
Montoya, María
author Karger, Axel
author_facet Karger, Axel
Pérez-Núñez, Daniel
Urquiza, Jesús
Hinojar, Patricia
Alonso Martí, Covadonga
Freitas, Ferdinando B.
Revilla Novella, Yolanda
Potier, Marie-Frédérique le
Montoya, María
author_role author
author2 Pérez-Núñez, Daniel
Urquiza, Jesús
Hinojar, Patricia
Alonso Martí, Covadonga
Freitas, Ferdinando B.
Revilla Novella, Yolanda
Potier, Marie-Frédérique le
Montoya, María
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Cooperation in Science and Technology
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv African swine fever virus
Virology
Proteomics
Virus-host interaction
topic African swine fever virus
Virology
Proteomics
Virus-host interaction
description Animal diseases constitute a continuing threat to animal health, food safety, national economy, and the environment. Among those, African swine fever (ASF) is one of the most devastating viruses affecting pigs and wild suids due to the lack of vaccine or effective treatment. ASF is endemic in countries in sub-Saharan Africa, but since its introduction to the Caucasus region in 2007, a highly virulent strain of ASF virus (ASFV) has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. Given the importance of this disease, this review will highlight recent discoveries in basic virology with special focus on proteomic analysis, replication cycle, and some recent data on genes involved in cycle progression and viral–host interactions, such as I215L (E2 ubiquitin-conjugating enzyme), EP402R (CD2v), A104R (histone-like protein), QP509L, and Q706L (RNA helicases) or P1192R (Topoisomerase II). Taking into consideration the large DNA genome of ASFV and its complex interactions with the host, more studies and new approaches are to be taken to understand the basic virus–host interaction for ASFV. Proteomic studies are just paving the way for future research.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/191382
url http://hdl.handle.net/10261/191382
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/v11090864
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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