Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group

Lopez, I; Aguinagalde, B; Urreta, I; Royo, I; Bolufer, S; Sanchez, L; Zabaleta, J; Fernandez-Monge, A; Recuero, JL; Sesma, J; Amor, S; Moradiellos, FJ; Arraras, MJ; Blanco, AI; Boada, M; Sanchez, D; Cabanero, A; Moreno, N; Cal, I; Moreno, R; Cilleruelo, A; Crowley, S; Gomez, D; Fernandez, E; Hernando, F; Garcia, S; Lopez, C; Garcia, MD; Garcia, JM; Rivo, JE; Garcia, JA; Gelbenzu, JJ; Ramirez, ME; Giraldo, CF; Mongil, R; Gomez, MT; Jimenez, M; Henandez, J; Fibla, JJ; Illana, J; Jauregui, A; Jimenez, U; Rojo, R; Martinez, NJ; Martinez, E; Trujillo, JC; Milla, L; Moreno, SB; Congregado, M; Obiols, C; Call, S; Quero, F; Ramos, R; Rodriguez, A; Simon, CM; Embun, R

Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group

Objectives: The objective of this study was to assess the diagnostic performance of combined computerised tomography (CT) and positron emission tomography (PET) in mediastinal staging of surgical lung cancer based on data obtained from the prospective cohort of the Spanish Group for Video-Assisted T...

Descripción completa

Detalles Bibliográficos
Autores:	Lopez, I, Aguinagalde, B, Urreta, I, Royo, I, Bolufer, S, Sanchez, L, Zabaleta, J, Fernandez-Monge, A, Recuero, JL, Sesma, J, Amor, S, Moradiellos, FJ, Arraras, MJ, Blanco, AI, Boada, M, Sanchez, D, Cabanero, A, Moreno, N, Cal, I, Moreno, R, Cilleruelo, A, Crowley, S, Gomez, D, Fernandez, E, Hernando, F, Garcia, S, Lopez, C, Garcia, MD, Garcia, JM, Rivo, JE, Garcia, JA, Gelbenzu, JJ, Ramirez, ME, Giraldo, CF, Mongil, R, Gomez, MT, Jimenez, M, Henandez, J, Fibla, JJ, Illana, J, Jauregui, A, Jimenez, U, Rojo, R, Martinez, NJ, Martinez, E, Trujillo, JC, Milla, L, Moreno, SB, Congregado, M, Obiols, C, Call, S, Quero, F, Ramos, R, Rodriguez, A, Simon, CM, Embun, R
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:	r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:	oai:fisabio.fundanetsuite.com:p15477
Acceso en línea:	https://fisabio.portalinvestigacion.com/publicaciones/15477
Access Level:	acceso abierto
Palabra clave:	Lung cancer Lung resection Mediastinal staging Lymph node staging Computerised tomography Positron emission tomography

id	ES_6dbb08cd9b1908fb19a2cc45e04b194c
oai_identifier_str	oai:fisabio.fundanetsuite.com:p15477
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery GroupLopez, IAguinagalde, BUrreta, IRoyo, IBolufer, SSanchez, LZabaleta, JFernandez-Monge, ARecuero, JLSesma, JAmor, SMoradiellos, FJArraras, MJBlanco, AIBoada, MSanchez, DCabanero, AMoreno, NCal, IMoreno, RCilleruelo, ACrowley, SGomez, DFernandez, EHernando, FGarcia, SLopez, CGarcia, MDGarcia, JMRivo, JEGarcia, JAGelbenzu, JJRamirez, MEGiraldo, CFMongil, RGomez, MTJimenez, MHenandez, JFibla, JJIllana, JJauregui, AJimenez, URojo, RMartinez, NJMartinez, ETrujillo, JCMilla, LMoreno, SBCongregado, MObiols, CCall, SQuero, FRamos, RRodriguez, ASimon, CMEmbun, RLung cancerLung resectionMediastinal stagingLymph node stagingComputerised tomographyPositron emission tomographyObjectives: The objective of this study was to assess the diagnostic performance of combined computerised tomography (CT) and positron emission tomography (PET) in mediastinal staging of surgical lung cancer based on data obtained from the prospective cohort of the Spanish Group for Video-Assisted Thoracic Surgery (GEVATS). Methods: A total of 2782 patients underwent surgery for primary lung carcinoma. We analysed diagnostic success in mediastinal lymph node staging (cN2) using CT and PET. Bivariate and multivariate analyses were performed of the factors involved in this success. The risk of unexpected pN2 disease was analysed for cases in which an invasive testing is recommended: cN1, the tumour centrally located or the tumour diameter >3 cm. Results: The overall success of CT together with PET was 82.9% with a positive predictive value of 0.21 and negative predictive value of 0.93. If the tumour was larger than 3 cm and for each unit increase in mediastinal SUVmax, the probability of success was lower with OR 0.59 (0.44-0.79) and 0.71 (0.66-0.75), respectively. In the video-assisted thoracic surgery (VATS) approach, the probability of success was higher with OR 2.04 (1.52-2.73). The risk of unexpected pN2 increased with the risk factors cN1, the tumour centrally located or the tumour diameter >3 cm: from 4.5% (0 factors) to 18.8% (3 factors) but did not differ significantly as a function of whether invasive testing was performed. Conclusions: CT and PET together have a high negative predictive value. The overall success of the staging is lower in the case of tumours >3 cm and high mediastinal SUVmax, and it is higher when VATS is performed. The risk of unexpected pN2 is higher if the disease is cN1, the tumour centrally located or the tumour diameter >3 cm but does not vary significantly as a function of whether patients have undergone invasive testing. (C) 2022 AEC. Published by Elsevier Espani a, S.L.U. All rights reserved.ELSEVIER ESPANA SLU2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/15477CIRUGIA ESPANOLAISSN: 0009739XISSNe: 1578147Xreponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Españolinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p154772026-06-11T12:45:17Z
dc.title.none.fl_str_mv	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
title	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
spellingShingle	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group Lopez, I Lung cancer Lung resection Mediastinal staging Lymph node staging Computerised tomography Positron emission tomography
title_short	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
title_full	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
title_fullStr	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
title_full_unstemmed	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
title_sort	Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group
dc.creator.none.fl_str_mv	Lopez, I Aguinagalde, B Urreta, I Royo, I Bolufer, S Sanchez, L Zabaleta, J Fernandez-Monge, A Recuero, JL Sesma, J Amor, S Moradiellos, FJ Arraras, MJ Blanco, AI Boada, M Sanchez, D Cabanero, A Moreno, N Cal, I Moreno, R Cilleruelo, A Crowley, S Gomez, D Fernandez, E Hernando, F Garcia, S Lopez, C Garcia, MD Garcia, JM Rivo, JE Garcia, JA Gelbenzu, JJ Ramirez, ME Giraldo, CF Mongil, R Gomez, MT Jimenez, M Henandez, J Fibla, JJ Illana, J Jauregui, A Jimenez, U Rojo, R Martinez, NJ Martinez, E Trujillo, JC Milla, L Moreno, SB Congregado, M Obiols, C Call, S Quero, F Ramos, R Rodriguez, A Simon, CM Embun, R
author	Lopez, I
author_facet	Lopez, I Aguinagalde, B Urreta, I Royo, I Bolufer, S Sanchez, L Zabaleta, J Fernandez-Monge, A Recuero, JL Sesma, J Amor, S Moradiellos, FJ Arraras, MJ Blanco, AI Boada, M Sanchez, D Cabanero, A Moreno, N Cal, I Moreno, R Cilleruelo, A Crowley, S Gomez, D Fernandez, E Hernando, F Garcia, S Lopez, C Garcia, MD Garcia, JM Rivo, JE Garcia, JA Gelbenzu, JJ Ramirez, ME Giraldo, CF Mongil, R Gomez, MT Jimenez, M Henandez, J Fibla, JJ Illana, J Jauregui, A Jimenez, U Rojo, R Martinez, NJ Martinez, E Trujillo, JC Milla, L Moreno, SB Congregado, M Obiols, C Call, S Quero, F Ramos, R Rodriguez, A Simon, CM Embun, R
author_role	author
author2	Aguinagalde, B Urreta, I Royo, I Bolufer, S Sanchez, L Zabaleta, J Fernandez-Monge, A Recuero, JL Sesma, J Amor, S Moradiellos, FJ Arraras, MJ Blanco, AI Boada, M Sanchez, D Cabanero, A Moreno, N Cal, I Moreno, R Cilleruelo, A Crowley, S Gomez, D Fernandez, E Hernando, F Garcia, S Lopez, C Garcia, MD Garcia, JM Rivo, JE Garcia, JA Gelbenzu, JJ Ramirez, ME Giraldo, CF Mongil, R Gomez, MT Jimenez, M Henandez, J Fibla, JJ Illana, J Jauregui, A Jimenez, U Rojo, R Martinez, NJ Martinez, E Trujillo, JC Milla, L Moreno, SB Congregado, M Obiols, C Call, S Quero, F Ramos, R Rodriguez, A Simon, CM Embun, R
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Lung cancer Lung resection Mediastinal staging Lymph node staging Computerised tomography Positron emission tomography
topic	Lung cancer Lung resection Mediastinal staging Lymph node staging Computerised tomography Positron emission tomography
description	Objectives: The objective of this study was to assess the diagnostic performance of combined computerised tomography (CT) and positron emission tomography (PET) in mediastinal staging of surgical lung cancer based on data obtained from the prospective cohort of the Spanish Group for Video-Assisted Thoracic Surgery (GEVATS). Methods: A total of 2782 patients underwent surgery for primary lung carcinoma. We analysed diagnostic success in mediastinal lymph node staging (cN2) using CT and PET. Bivariate and multivariate analyses were performed of the factors involved in this success. The risk of unexpected pN2 disease was analysed for cases in which an invasive testing is recommended: cN1, the tumour centrally located or the tumour diameter >3 cm. Results: The overall success of CT together with PET was 82.9% with a positive predictive value of 0.21 and negative predictive value of 0.93. If the tumour was larger than 3 cm and for each unit increase in mediastinal SUVmax, the probability of success was lower with OR 0.59 (0.44-0.79) and 0.71 (0.66-0.75), respectively. In the video-assisted thoracic surgery (VATS) approach, the probability of success was higher with OR 2.04 (1.52-2.73). The risk of unexpected pN2 increased with the risk factors cN1, the tumour centrally located or the tumour diameter >3 cm: from 4.5% (0 factors) to 18.8% (3 factors) but did not differ significantly as a function of whether invasive testing was performed. Conclusions: CT and PET together have a high negative predictive value. The overall success of the staging is lower in the case of tumours >3 cm and high mediastinal SUVmax, and it is higher when VATS is performed. The risk of unexpected pN2 is higher if the disease is cN1, the tumour centrally located or the tumour diameter >3 cm but does not vary significantly as a function of whether patients have undergone invasive testing. (C) 2022 AEC. Published by Elsevier Espani a, S.L.U. All rights reserved.
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://fisabio.portalinvestigacion.com/publicaciones/15477
url	https://fisabio.portalinvestigacion.com/publicaciones/15477
dc.language.none.fl_str_mv	Español
language_invalid_str_mv	Español
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER ESPANA SLU
publisher.none.fl_str_mv	ELSEVIER ESPANA SLU
dc.source.none.fl_str_mv	CIRUGIA ESPANOLA ISSN: 0009739X ISSNe: 1578147X reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str	Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str	r-FISABIO. Repositorio Institucional de Producción Científica
collection	r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869410373358059520
score	15.811543

Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group

Similares en LA Referencia