Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles

The present study aimed to evaluate the larvicidal activity, the aquatic and subacute toxicity of anacardic acid in solution and encapsulated in zein nanoparticles. For the larvicidal potential, different anacardic acid concentrations were tested against young A. aegypti larvae, determining the mort...

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Autores: Pinto, Eduardo Júnior Serrão, de Araujo, Jennifer Thayanne Cavalcante, dos Anjos Ferreira, Ricardo Marcelo, Picanço Souto, Raimundo Nonato, Aragão Lima, Laís, de Barros Silva, Paulo Goberlânio, García Ramón, María Teresa, Fuente, Ana de la, Oliveira de Sousa, Francisco Fábio
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/239388
Acesso em linha:http://hdl.handle.net/10261/239388
Access Level:Acceso aberto
Palavra-chave:Toxicity
Anacardic acid
Zein
Daphnia magna
Nanoparticles
Larvicide
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spelling Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticlesPinto, Eduardo Júnior Serrãode Araujo, Jennifer Thayanne Cavalcantedos Anjos Ferreira, Ricardo MarceloPicanço Souto, Raimundo NonatoAragão Lima, Laísde Barros Silva, Paulo GoberlânioGarcía Ramón, María TeresaFuente, Ana de laOliveira de Sousa, Francisco FábioToxicityAnacardic acidZeinDaphnia magnaNanoparticlesLarvicideThe present study aimed to evaluate the larvicidal activity, the aquatic and subacute toxicity of anacardic acid in solution and encapsulated in zein nanoparticles. For the larvicidal potential, different anacardic acid concentrations were tested against young A. aegypti larvae, determining the mortality rates at 24, 48 h and the residual effect between 1 and 4 weeks. For the acute ecotoxicology test, Daphnia magna was selected as the untargeted environmental organism. To evaluate the subacute toxicity, blank and anacardic acid loaded-zein nanoparticles were administered orally to Swiss mice in the dose of 2.25 μg/kg for 7 days. Anacardic acid loaded-zein nanoparticles showed remarkable larvicidal activity up to 48 h at very low concentrations. Moreover, under the larvicide concentrations mortality was limited in aquatic toxicity assay, while no signs of toxicity were found in the mice treated with blank or anacardic acid nanoparticles. Accordingly, the anacardic acid nanoformulations were found to be very potent and efficient on eliminating A. aegypt larvae, and also unhazardous to non-target species, representing a new larvicide candidate against arboviruses diseases’ vectors.This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES), providing scholarships to Pinto, E.J.S. and Araújo, J.T.C. The present work was accomplished with the support of the National Program of Cooperation in the Amazon – PROCAD/Amazon of Coordination of Superior Level Staff Improvement– CAPES/Brazil. We would like to thank Fundação de Amparo à Pesquisa do Estado do Amapá (FAPEAP) and CNPq for supporing this research (EDITAL PRONEM, grant # 95/2018). This research also received financial support from PAPESQ Program (EDITAL N° 14/2017) from Federal University of Amapa. We thank the Research Laboratory of Drugs (LPFar) of Federal Universty of Amapa for the nanoparticles characterization analysis, the Laboratory of Hospital Instituto Dr. José Frota (IJF) for the anticholinesterase test and Unichristus bioterium for providing the animals used in the study.Peer reviewedElsevierConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/239388reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.jddst.2021.102513Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2393882026-05-22T06:33:51Z
dc.title.none.fl_str_mv Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
title Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
spellingShingle Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
Pinto, Eduardo Júnior Serrão
Toxicity
Anacardic acid
Zein
Daphnia magna
Nanoparticles
Larvicide
title_short Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
title_full Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
title_fullStr Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
title_full_unstemmed Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
title_sort Larvicidal activity, aquatic and in vivo toxicity of anacardic acid loaded-zein nanoparticles
dc.creator.none.fl_str_mv Pinto, Eduardo Júnior Serrão
de Araujo, Jennifer Thayanne Cavalcante
dos Anjos Ferreira, Ricardo Marcelo
Picanço Souto, Raimundo Nonato
Aragão Lima, Laís
de Barros Silva, Paulo Goberlânio
García Ramón, María Teresa
Fuente, Ana de la
Oliveira de Sousa, Francisco Fábio
author Pinto, Eduardo Júnior Serrão
author_facet Pinto, Eduardo Júnior Serrão
de Araujo, Jennifer Thayanne Cavalcante
dos Anjos Ferreira, Ricardo Marcelo
Picanço Souto, Raimundo Nonato
Aragão Lima, Laís
de Barros Silva, Paulo Goberlânio
García Ramón, María Teresa
Fuente, Ana de la
Oliveira de Sousa, Francisco Fábio
author_role author
author2 de Araujo, Jennifer Thayanne Cavalcante
dos Anjos Ferreira, Ricardo Marcelo
Picanço Souto, Raimundo Nonato
Aragão Lima, Laís
de Barros Silva, Paulo Goberlânio
García Ramón, María Teresa
Fuente, Ana de la
Oliveira de Sousa, Francisco Fábio
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Toxicity
Anacardic acid
Zein
Daphnia magna
Nanoparticles
Larvicide
topic Toxicity
Anacardic acid
Zein
Daphnia magna
Nanoparticles
Larvicide
description The present study aimed to evaluate the larvicidal activity, the aquatic and subacute toxicity of anacardic acid in solution and encapsulated in zein nanoparticles. For the larvicidal potential, different anacardic acid concentrations were tested against young A. aegypti larvae, determining the mortality rates at 24, 48 h and the residual effect between 1 and 4 weeks. For the acute ecotoxicology test, Daphnia magna was selected as the untargeted environmental organism. To evaluate the subacute toxicity, blank and anacardic acid loaded-zein nanoparticles were administered orally to Swiss mice in the dose of 2.25 μg/kg for 7 days. Anacardic acid loaded-zein nanoparticles showed remarkable larvicidal activity up to 48 h at very low concentrations. Moreover, under the larvicide concentrations mortality was limited in aquatic toxicity assay, while no signs of toxicity were found in the mice treated with blank or anacardic acid nanoparticles. Accordingly, the anacardic acid nanoformulations were found to be very potent and efficient on eliminating A. aegypt larvae, and also unhazardous to non-target species, representing a new larvicide candidate against arboviruses diseases’ vectors.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/239388
url http://hdl.handle.net/10261/239388
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.jddst.2021.102513
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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