Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET

Introduction: The objective of this study was to investigate and compare optic nerve and retinal layers in eyes of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) with paired control eyes using optical coherence tomography. Methods: Sixty-three eyes of 34 subjects, 12...

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Autores: López de Eguileta Rodríguez, Alicia, Lage, Carmen, López García, Sara, Pozueta, Ana, García Martínez, María, Kazimierczak, Martha, Bravo, María, Arcocha Torres, María de, Banzo, Ignacio, Jimenez-Bonilla, Julio, Cerveró Varona, Andrea|||0000-0002-1780-8239, Rodríguez Rodríguez, Eloy Manuel, Sánchez-Juan, Pascual|||0000-0002-6081-8037, Casado, Alfonso
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/18946
Acceso en línea:http://hdl.handle.net/10902/18946
Access Level:acceso abierto
Palabra clave:Alzheimer Disease
Retinal Nerve Fiber Layer
Optical Coherence Tomography
Ganglion
Ganglion Cell Layer
Positrón Emission Tomography
Mild Cognitive Impairment
Lamina Cribrosa
Bruch’s Membrane Opening–Minimum Rim Width
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spelling Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PETLópez de Eguileta Rodríguez, AliciaLage, CarmenLópez García, SaraPozueta, AnaGarcía Martínez, MaríaKazimierczak, MarthaBravo, MaríaArcocha Torres, María deBanzo, IgnacioJimenez-Bonilla, JulioCerveró Varona, Andrea|||0000-0002-1780-8239Rodríguez Rodríguez, Eloy ManuelSánchez-Juan, Pascual|||0000-0002-6081-8037Casado, AlfonsoAlzheimer DiseaseRetinal Nerve Fiber LayerOptical Coherence TomographyGanglionGanglion Cell LayerPositrón Emission TomographyMild Cognitive ImpairmentLamina CribrosaBruch’s Membrane Opening–Minimum Rim WidthIntroduction: The objective of this study was to investigate and compare optic nerve and retinal layers in eyes of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) with paired control eyes using optical coherence tomography. Methods: Sixty-three eyes of 34 subjects, 12 eyes with AD and 51 eyes with MCI, positive to 11C-labeled Pittsburgh Compound-B with positron emission tomography (11C-PiB PET/CT), and the same number of sex- and age-paired control eyes underwent optical coherence tomography scanning analyzing retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), Bruch's membrane opening-minimum rim width (BMO-MRW), inner plexiform layer (IPL), outer nuclear layer, and lamina cribrosa (LC). Results: Compared with healthy controls, eyes of patients with positive 11C-PiB PET/CT showed a significant thinning of RNFL (P < .028) and GCL (P < .014). IPL and outer nuclear layer also showed significant thinning in two (P < .025) and one location (P < .010), respectively. No significant differences were found when optic nerve measurements BMO-MRW and LC were compared (P > .131 and P > .721, respectively). Temporal sector GCL, average RNFL, and temporal sector RNFL also exhibited significant thinning when MCI and control eyes were compared (P = .015, P = .005 and P = .050, respectively), and also the greatest area under the curve values (0.689, 0.647, and 0.659, respectively). GCL, IPL, and RNFL tend to be thinner in the AD group compared with healthy controls. Discussion: Our study suggests that RNFL and GCL are useful for potential screening in the early diagnosis of AD. LC and BMO-MRW appear not to be affected by AD.Acknowledgments: P.S.J. was supported by grants from IDIVAL, Instituto de Salud Carlos III (Fondo de Investigacion Sanitario, PI08/0139, PI12/02288, PI16/01652), JPND (DEMTEST PI11/03028) and the CIBERNED program and Siemens Healthineers (Valdecilla Cohort for Memory and Brain Aging). A.C. conducted the statistical analysis.ElsevierUniversidad de Cantabria20192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/18946Alzheimers Dement (N Y) . 2019 Oct 9;5:570-578.reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/189462026-06-02T12:39:31Z
dc.title.none.fl_str_mv Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
title Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
spellingShingle Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
López de Eguileta Rodríguez, Alicia
Alzheimer Disease
Retinal Nerve Fiber Layer
Optical Coherence Tomography
Ganglion
Ganglion Cell Layer
Positrón Emission Tomography
Mild Cognitive Impairment
Lamina Cribrosa
Bruch’s Membrane Opening–Minimum Rim Width
title_short Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
title_full Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
title_fullStr Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
title_full_unstemmed Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
title_sort Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
dc.creator.none.fl_str_mv López de Eguileta Rodríguez, Alicia
Lage, Carmen
López García, Sara
Pozueta, Ana
García Martínez, María
Kazimierczak, Martha
Bravo, María
Arcocha Torres, María de
Banzo, Ignacio
Jimenez-Bonilla, Julio
Cerveró Varona, Andrea|||0000-0002-1780-8239
Rodríguez Rodríguez, Eloy Manuel
Sánchez-Juan, Pascual|||0000-0002-6081-8037
Casado, Alfonso
author López de Eguileta Rodríguez, Alicia
author_facet López de Eguileta Rodríguez, Alicia
Lage, Carmen
López García, Sara
Pozueta, Ana
García Martínez, María
Kazimierczak, Martha
Bravo, María
Arcocha Torres, María de
Banzo, Ignacio
Jimenez-Bonilla, Julio
Cerveró Varona, Andrea|||0000-0002-1780-8239
Rodríguez Rodríguez, Eloy Manuel
Sánchez-Juan, Pascual|||0000-0002-6081-8037
Casado, Alfonso
author_role author
author2 Lage, Carmen
López García, Sara
Pozueta, Ana
García Martínez, María
Kazimierczak, Martha
Bravo, María
Arcocha Torres, María de
Banzo, Ignacio
Jimenez-Bonilla, Julio
Cerveró Varona, Andrea|||0000-0002-1780-8239
Rodríguez Rodríguez, Eloy Manuel
Sánchez-Juan, Pascual|||0000-0002-6081-8037
Casado, Alfonso
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Alzheimer Disease
Retinal Nerve Fiber Layer
Optical Coherence Tomography
Ganglion
Ganglion Cell Layer
Positrón Emission Tomography
Mild Cognitive Impairment
Lamina Cribrosa
Bruch’s Membrane Opening–Minimum Rim Width
topic Alzheimer Disease
Retinal Nerve Fiber Layer
Optical Coherence Tomography
Ganglion
Ganglion Cell Layer
Positrón Emission Tomography
Mild Cognitive Impairment
Lamina Cribrosa
Bruch’s Membrane Opening–Minimum Rim Width
description Introduction: The objective of this study was to investigate and compare optic nerve and retinal layers in eyes of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) with paired control eyes using optical coherence tomography. Methods: Sixty-three eyes of 34 subjects, 12 eyes with AD and 51 eyes with MCI, positive to 11C-labeled Pittsburgh Compound-B with positron emission tomography (11C-PiB PET/CT), and the same number of sex- and age-paired control eyes underwent optical coherence tomography scanning analyzing retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), Bruch's membrane opening-minimum rim width (BMO-MRW), inner plexiform layer (IPL), outer nuclear layer, and lamina cribrosa (LC). Results: Compared with healthy controls, eyes of patients with positive 11C-PiB PET/CT showed a significant thinning of RNFL (P < .028) and GCL (P < .014). IPL and outer nuclear layer also showed significant thinning in two (P < .025) and one location (P < .010), respectively. No significant differences were found when optic nerve measurements BMO-MRW and LC were compared (P > .131 and P > .721, respectively). Temporal sector GCL, average RNFL, and temporal sector RNFL also exhibited significant thinning when MCI and control eyes were compared (P = .015, P = .005 and P = .050, respectively), and also the greatest area under the curve values (0.689, 0.647, and 0.659, respectively). GCL, IPL, and RNFL tend to be thinner in the AD group compared with healthy controls. Discussion: Our study suggests that RNFL and GCL are useful for potential screening in the early diagnosis of AD. LC and BMO-MRW appear not to be affected by AD.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/18946
url http://hdl.handle.net/10902/18946
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Alzheimers Dement (N Y) . 2019 Oct 9;5:570-578.
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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