Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients

Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed u...

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Detalles Bibliográficos
Autores: Fuso, Paola, Di Salvatore, Mariantonietta, Santonocito, Concetta, Guarino, Donatella, Autilio, Chiara, Mulè, Antonino, Arciuolo, Damiano, Rinninella, Antonina, Mignone, Flavio, Ramundo, Matteo, Di Stefano, Brunella, Orlandi, Armando, Capoluongo, Ettore, Nicolotti, Nicola, Franceschini, Gianluca, Martín Sánchez, Alejandro, Tortora, Giampaolo, Scambia, Giovanni, Barone, Carlo, Cassano, Alessandra
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/4934
Acceso en línea:https://hdl.handle.net/20.500.14352/4934
Access Level:acceso abierto
Palabra clave:subtypes breast cancer
miRNAs
breast cancer treatment
chemotherapy
integrated therapies
next-generation-sequencing
target therapy
precision medicine
personalized medicine
Oncología
3201.01 Oncología
Descripción
Sumario:Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system. Results: Event-free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let-7a-5p (EFS p = 0.006; OS p = 0.0001), mirR-100-5p (EFS s p = 0.01; OS p = 0.03), miR-101-3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer.

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