Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico

It is difficult to tackle the problem of the origin of life without a notion of what life is and how it behaves. Probably, the concept of self-organization constitutes one of the keys for understanding biological systems and, in particular, their emergence from a prebiotic scenario of complex but st...

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Detalles Bibliográficos
Autor: Piedrafita Fernández, Gabriel
Tipo de recurso: tesis doctoral
Fecha de publicación:2014
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/38066
Acceso en línea:https://hdl.handle.net/20.500.14352/38066
Access Level:acceso abierto
Palabra clave:577.2(043.2)
Biología molecular
Biología molecular (Química)
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spelling Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólicoPiedrafita Fernández, Gabriel577.2(043.2)Biología molecularBiología molecular (Química)It is difficult to tackle the problem of the origin of life without a notion of what life is and how it behaves. Probably, the concept of self-organization constitutes one of the keys for understanding biological systems and, in particular, their emergence from a prebiotic scenario of complex but still inert chemical systems. The study of irreversible processes and the development of far-from-equilibrium thermodynamics (mainly following Prigogine’s school (Nicolis and Prigogine, 1977), together with the know-how and dynamic characterization of diverse selforganizing phenomena in living beings, has given some important clues to unravel possible principles involved in this transition to living matter. However, they have proved clearly insufficient. Beyond self-organization, a certain idea of closure appears at the basis of most theories of the living that have proposed and attempted a universal characterization of biological systems from its most elementary level (Letelier et al., 2011). These theories claim that living entities should indeed be distinguished by a common, fundamental type of organization and offer solutions to model and characterize it, determining in this way what constitutes the essence of every living system and the reason for its being alive. In this context, the notion of organizational closure appears expressed in various different formalisms and with different degrees of precision among the distinct theories, but they are usually rooted in a common concern: the fact that living organisms must not only organize themselves from within; they must also maintain their organization in the face of changes in their environment and the continuous degradation of their components, highlighting the need of active molecular mechanisms (self-construction) to achieve self-maintenance. This problem is specially addressed in the theory of autopoiesis (Varela et al.,1974) and the theory of (M,R) systems or metabolism-repair systems (Rosen, 1971). According to Rosen, organisms are closed to efficient causation, which means that all the catalysts (efficient causes) required for an organism to stay alive must be products of the organism activity itself...Universidad Complutense de MadridMorán Abad, FedericoRuiz Mirazo , KepaMontero Carnerero, FranciscoUniversidad Complutense de Madrid20142014-01-0720142014-01-07doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/38066reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/380662026-06-02T12:44:21Z
dc.title.none.fl_str_mv Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
title Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
spellingShingle Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
Piedrafita Fernández, Gabriel
577.2(043.2)
Biología molecular
Biología molecular (Química)
title_short Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
title_full Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
title_fullStr Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
title_full_unstemmed Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
title_sort Desarrollo de un modelo semiempírico de sistema protocelular automantenido con cierre metabólico
dc.creator.none.fl_str_mv Piedrafita Fernández, Gabriel
author Piedrafita Fernández, Gabriel
author_facet Piedrafita Fernández, Gabriel
author_role author
dc.contributor.none.fl_str_mv Morán Abad, Federico
Ruiz Mirazo , Kepa
Montero Carnerero, Francisco
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.2(043.2)
Biología molecular
Biología molecular (Química)
topic 577.2(043.2)
Biología molecular
Biología molecular (Química)
description It is difficult to tackle the problem of the origin of life without a notion of what life is and how it behaves. Probably, the concept of self-organization constitutes one of the keys for understanding biological systems and, in particular, their emergence from a prebiotic scenario of complex but still inert chemical systems. The study of irreversible processes and the development of far-from-equilibrium thermodynamics (mainly following Prigogine’s school (Nicolis and Prigogine, 1977), together with the know-how and dynamic characterization of diverse selforganizing phenomena in living beings, has given some important clues to unravel possible principles involved in this transition to living matter. However, they have proved clearly insufficient. Beyond self-organization, a certain idea of closure appears at the basis of most theories of the living that have proposed and attempted a universal characterization of biological systems from its most elementary level (Letelier et al., 2011). These theories claim that living entities should indeed be distinguished by a common, fundamental type of organization and offer solutions to model and characterize it, determining in this way what constitutes the essence of every living system and the reason for its being alive. In this context, the notion of organizational closure appears expressed in various different formalisms and with different degrees of precision among the distinct theories, but they are usually rooted in a common concern: the fact that living organisms must not only organize themselves from within; they must also maintain their organization in the face of changes in their environment and the continuous degradation of their components, highlighting the need of active molecular mechanisms (self-construction) to achieve self-maintenance. This problem is specially addressed in the theory of autopoiesis (Varela et al.,1974) and the theory of (M,R) systems or metabolism-repair systems (Rosen, 1971). According to Rosen, organisms are closed to efficient causation, which means that all the catalysts (efficient causes) required for an organism to stay alive must be products of the organism activity itself...
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-07
2014
2014-01-07
dc.type.none.fl_str_mv doctoral thesis
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format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/38066
url https://hdl.handle.net/20.500.14352/38066
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
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