Epidemiological and genetic characterization of Norovirus outbreaks occurred in Catalonia, Spain, 2017-2019

Molecular characterization of human norovirus (HuNoV) genotypes enhances the understanding of viral features and illustrates distinctive evolutionary patterns. The aim of our study was to describe the prevalence of the genetic diversity and the epidemiology of the genotypes involved in HuNoV outbrea...

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Detalles Bibliográficos
Autores: Anfruns-Estrada, Eduard, Sabaté, Sara, Razquin, Efrén, Cornejo Sánchez, Thais, Bartolomé, Rosa, Torner Gràcia, Núria, Izquierdo, Conchita, Soldevila, Núria, Coronas, Lorena, Domínguez García, Àngela, Fuentes Pardo, Cristina, Pintó Solé, Rosa María, Bosch, Albert, Guix Arnau, Susana, Working Group for the Study of Outbreaks of Acute
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/186034
Acceso en línea:https://hdl.handle.net/2445/186034
Access Level:acceso abierto
Palabra clave:Epidemiologia molecular
Espanya
Gastroenteritis
Molecular epidemiology
Spain
Descripción
Sumario:Molecular characterization of human norovirus (HuNoV) genotypes enhances the understanding of viral features and illustrates distinctive evolutionary patterns. The aim of our study was to describe the prevalence of the genetic diversity and the epidemiology of the genotypes involved in HuNoV outbreaks in Catalonia (Spain) between 2017 and 2019. A total of 100 HuNoV outbreaks were notified with the predominance of GII (70%), followed by GI (27%) and mixed GI/GII (3%). Seasonality was observed for GII outbreaks only. The most prevalent genotypes identified were GII.4[P31] Sydney 2012, GII.4[P16] Sydney 2012 and GII.2[P16]. As compared to person-to-person (P/P) transmitted outbreaks, foodborne outbreaks showed significantly higher attack rates and lower duration. The average attack rate was higher in youth hostel/campgrounds compared to nursing homes. Only genotypes GI.4[P4], GII.2[P16], GII.4[P16], GII.4[P31] and GII.17[P17] were consistently detected every year, and only abundance of GII.2[P16] showed a negative trend over time. GII.4 Sydney 2012 outbreaks were significantly associated to nursing homes, while GII.2[P16] and GI.3[P3] were most frequently identified in youth hostel/campgrounds. The average attack rate was significantly higher when comparing GII.2[P16] vs. GI.4[P4], GII.2[P16] vs. GII.4[P31] Sydney 2012, and GII.6[P7] vs. GII.4[P31] Sydney 2012. No correlations were found between genotype and outbreak duration or age of affected individuals.

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