The Breast Milk Immunoglobulinome

Breast milk components contribute to the infant's immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs suc...

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Autores: Rio-Aige, Karla, Azagra Boronat, Ignasi, Castell, Margarida, Selma-Royo, Marta, Collado, Maria Carmen, Rodríguez Lagunas, María José, Pérez-Cano, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178469
Acceso en línea:https://hdl.handle.net/2445/178469
Access Level:acceso abierto
Palabra clave:Immunoglobulines
Llet materna
Microbiota intestinal
Immunoglobulins
Breast milk
Gastrointestinal microbiome
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spelling The Breast Milk ImmunoglobulinomeRio-Aige, KarlaAzagra Boronat, IgnasiCastell, MargaridaSelma-Royo, MartaCollado, Maria CarmenRodríguez Lagunas, María JoséPérez-Cano, Francisco J.ImmunoglobulinesLlet maternaMicrobiota intestinalImmunoglobulinsBreast milkGastrointestinal microbiomeBreast milk components contribute to the infant's immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs such as IgM, IgG, and their subtypes (IgG1, IgG2, IgG3, and IgG4) or even IgE or IgD. The total Ig concentration and profile will change during the course of lactation; however, there is a great variability among studies due to several variables that limit establishing a clear pattern. In this context, the aim of this review was firstly to shed light on the Ig concentration in breast milk based on scientific evidence and secondly to study the main factors contributing to such variability. A search strategy provided only 75 studies with the prespecified eligibility criteria. The concentrations and proportions found have been established based on the intrinsic factors of the study¿such as the sampling time and quantification technique¿as well as participant-dependent factors, such as lifestyle and environment. All these factors contribute to the variability of the immunoglobulinome described in the literature and should be carefully addressed for further well-designed studies and data interpretation.MDPI2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/178469Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu13061810Nutrients, 2021, vol. 13, p. 1810https://doi.org/10.3390/nu13061810info:eu-repo/grantAgreement/EC/H2020/639226cc-by (c) Rio-Aige, Karla et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1784692026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Breast Milk Immunoglobulinome
title The Breast Milk Immunoglobulinome
spellingShingle The Breast Milk Immunoglobulinome
Rio-Aige, Karla
Immunoglobulines
Llet materna
Microbiota intestinal
Immunoglobulins
Breast milk
Gastrointestinal microbiome
title_short The Breast Milk Immunoglobulinome
title_full The Breast Milk Immunoglobulinome
title_fullStr The Breast Milk Immunoglobulinome
title_full_unstemmed The Breast Milk Immunoglobulinome
title_sort The Breast Milk Immunoglobulinome
dc.creator.none.fl_str_mv Rio-Aige, Karla
Azagra Boronat, Ignasi
Castell, Margarida
Selma-Royo, Marta
Collado, Maria Carmen
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
author Rio-Aige, Karla
author_facet Rio-Aige, Karla
Azagra Boronat, Ignasi
Castell, Margarida
Selma-Royo, Marta
Collado, Maria Carmen
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
author_role author
author2 Azagra Boronat, Ignasi
Castell, Margarida
Selma-Royo, Marta
Collado, Maria Carmen
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Immunoglobulines
Llet materna
Microbiota intestinal
Immunoglobulins
Breast milk
Gastrointestinal microbiome
topic Immunoglobulines
Llet materna
Microbiota intestinal
Immunoglobulins
Breast milk
Gastrointestinal microbiome
description Breast milk components contribute to the infant's immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs such as IgM, IgG, and their subtypes (IgG1, IgG2, IgG3, and IgG4) or even IgE or IgD. The total Ig concentration and profile will change during the course of lactation; however, there is a great variability among studies due to several variables that limit establishing a clear pattern. In this context, the aim of this review was firstly to shed light on the Ig concentration in breast milk based on scientific evidence and secondly to study the main factors contributing to such variability. A search strategy provided only 75 studies with the prespecified eligibility criteria. The concentrations and proportions found have been established based on the intrinsic factors of the study¿such as the sampling time and quantification technique¿as well as participant-dependent factors, such as lifestyle and environment. All these factors contribute to the variability of the immunoglobulinome described in the literature and should be carefully addressed for further well-designed studies and data interpretation.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178469
url https://hdl.handle.net/2445/178469
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu13061810
Nutrients, 2021, vol. 13, p. 1810
https://doi.org/10.3390/nu13061810
info:eu-repo/grantAgreement/EC/H2020/639226
dc.rights.none.fl_str_mv cc-by (c) Rio-Aige, Karla et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rio-Aige, Karla et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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