Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water
The introduction of drinking water disinfection greatly reduced waterborne diseases. However, the reaction between disinfectants and natural organic matter in the source water leads to an unintended consequence, the formation of drinking water disinfection byproducts (DBPs). The haloacetaldehydes (H...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/376444 |
| Acceso en línea: | http://hdl.handle.net/10261/376444 https://api.elsevier.com/content/abstract/scopus_id/84939633622 |
| Access Level: | acceso abierto |
| Palabra clave: | Haloacetaldehyde Disinfection Byproducts Drinking water Anions Antimicrobial activity Toxicity Hydration http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/6 Ensure healthy lives and promote well-being for all at all ages Ensure availability and sustainable management of water and sanitation for all Make cities and human settlements inclusive, safe, resilient and sustainable |
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Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking WaterJeong, Clara H.Postigo, CristinaRichardson, Susan D.Simmons, Jane EllenKimura, Susana Y.Mariñas, Benito J.Barceló, DamiàLiang, PeiWagner, Elizabeth D.Plewa, Michael J.Haloacetaldehyde Disinfection ByproductsDrinking waterAnionsAntimicrobial activityToxicityHydrationhttp://metadata.un.org/sdg/11http://metadata.un.org/sdg/3http://metadata.un.org/sdg/6Ensure healthy lives and promote well-being for all at all agesEnsure availability and sustainable management of water and sanitation for allMake cities and human settlements inclusive, safe, resilient and sustainableThe introduction of drinking water disinfection greatly reduced waterborne diseases. However, the reaction between disinfectants and natural organic matter in the source water leads to an unintended consequence, the formation of drinking water disinfection byproducts (DBPs). The haloacetaldehydes (HALs) are the third largest group by weight of identified DBPs in drinking water. The primary objective of this study was to analyze the occurrence and comparative toxicity of the emerging HAL DBPs. A new HAL DBP, iodoacetaldehyde (IAL) was identified. This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells. The rank order of HAL cytotoxicity is tribromoacetaldehyde (TBAL) ≈ chloroacetaldehyde (CAL) > dibromoacetaldehyde (DBAL) ≈ bromochloroacetaldehyde (BCAL) ≈ dibromochloroacetaldehyde (DBCAL) > IAL > bromoacetaldehyde (BAL) ≈ bromodichloroacetaldehyde (BDCAL) > dichloroacetaldehyde (DCAL) > trichloroacetaldehyde (TCAL). The HALs were highly cytotoxic compared to other DBP chemical classes. The rank order of HAL genotoxicity is DBAL > CAL ≈ DBCAL > TBAL ≈ BAL > BDCAL>BCAL ≈ DCAL>IAL. TCAL was not genotoxic. Because of their toxicity and abundance, further research is needed to investigate their mode of action to protect the public health and the environment.We would like to thank the drinking water treatment plants for generously providing us with samples and Yusupha Sey for excellent technical support. This work was supported by the U.S. EPA STAR Grant R834867. We appreciate support by the Center of Advanced Materials for the Purification of Water with Systems (WaterCAMPWS), a National Science Foundation Science and Technology Center, under Award CTS-0120978. C.J. was supported by a NIEHS Predoctoral Fellowship under Grant No. T32 ES007326. C.P. acknowledges support from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 274379 (Marie Curie IOF). This work has been financially supported by the Generalitat de Catalunya (Consolidated Research Groups “2014 SGR 418 - Water and Soil Quality Unit” and 2014 SGR 291 - ICRA). This work reflects only the authors’ views. The EU is not liable for any use that may be made of the information contained therein. The information in this document was funded in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.Peer reviewedAmerican Chemical SocietyEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/376444https://api.elsevier.com/content/abstract/scopus_id/84939633622reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/274379Environmental science & technologyhttps://doi.org/10.1021/es506358xSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3764442026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| title |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| spellingShingle |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water Jeong, Clara H. Haloacetaldehyde Disinfection Byproducts Drinking water Anions Antimicrobial activity Toxicity Hydration http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/6 Ensure healthy lives and promote well-being for all at all ages Ensure availability and sustainable management of water and sanitation for all Make cities and human settlements inclusive, safe, resilient and sustainable |
| title_short |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| title_full |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| title_fullStr |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| title_full_unstemmed |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| title_sort |
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water |
| dc.creator.none.fl_str_mv |
Jeong, Clara H. Postigo, Cristina Richardson, Susan D. Simmons, Jane Ellen Kimura, Susana Y. Mariñas, Benito J. Barceló, Damià Liang, Pei Wagner, Elizabeth D. Plewa, Michael J. |
| author |
Jeong, Clara H. |
| author_facet |
Jeong, Clara H. Postigo, Cristina Richardson, Susan D. Simmons, Jane Ellen Kimura, Susana Y. Mariñas, Benito J. Barceló, Damià Liang, Pei Wagner, Elizabeth D. Plewa, Michael J. |
| author_role |
author |
| author2 |
Postigo, Cristina Richardson, Susan D. Simmons, Jane Ellen Kimura, Susana Y. Mariñas, Benito J. Barceló, Damià Liang, Pei Wagner, Elizabeth D. Plewa, Michael J. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Haloacetaldehyde Disinfection Byproducts Drinking water Anions Antimicrobial activity Toxicity Hydration http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/6 Ensure healthy lives and promote well-being for all at all ages Ensure availability and sustainable management of water and sanitation for all Make cities and human settlements inclusive, safe, resilient and sustainable |
| topic |
Haloacetaldehyde Disinfection Byproducts Drinking water Anions Antimicrobial activity Toxicity Hydration http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/6 Ensure healthy lives and promote well-being for all at all ages Ensure availability and sustainable management of water and sanitation for all Make cities and human settlements inclusive, safe, resilient and sustainable |
| description |
The introduction of drinking water disinfection greatly reduced waterborne diseases. However, the reaction between disinfectants and natural organic matter in the source water leads to an unintended consequence, the formation of drinking water disinfection byproducts (DBPs). The haloacetaldehydes (HALs) are the third largest group by weight of identified DBPs in drinking water. The primary objective of this study was to analyze the occurrence and comparative toxicity of the emerging HAL DBPs. A new HAL DBP, iodoacetaldehyde (IAL) was identified. This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells. The rank order of HAL cytotoxicity is tribromoacetaldehyde (TBAL) ≈ chloroacetaldehyde (CAL) > dibromoacetaldehyde (DBAL) ≈ bromochloroacetaldehyde (BCAL) ≈ dibromochloroacetaldehyde (DBCAL) > IAL > bromoacetaldehyde (BAL) ≈ bromodichloroacetaldehyde (BDCAL) > dichloroacetaldehyde (DCAL) > trichloroacetaldehyde (TCAL). The HALs were highly cytotoxic compared to other DBP chemical classes. The rank order of HAL genotoxicity is DBAL > CAL ≈ DBCAL > TBAL ≈ BAL > BDCAL>BCAL ≈ DCAL>IAL. TCAL was not genotoxic. Because of their toxicity and abundance, further research is needed to investigate their mode of action to protect the public health and the environment. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2025 2025 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Postprint info:eu-repo/semantics/acceptedVersion |
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article |
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acceptedVersion |
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http://hdl.handle.net/10261/376444 https://api.elsevier.com/content/abstract/scopus_id/84939633622 |
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http://hdl.handle.net/10261/376444 https://api.elsevier.com/content/abstract/scopus_id/84939633622 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/274379 Environmental science & technology https://doi.org/10.1021/es506358x Sí |
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info:eu-repo/semantics/openAccess |
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American Chemical Society |
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American Chemical Society |
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