Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis

Factors de risc mèdic; Medicina diagnòstica; Tripanosoma cruzi

Bibliographic Details
Authors: Suescún-Carrero, Sandra Helena, Tadger, Philippe, Sandoval-Cuellar, Carolina, Armadans, Lluis, Ramirez Lopez, Laura Ximena
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Departament de Salut de la Generalitat de Catalunya (DS)
Repository:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/8519
Online Access:https://hdl.handle.net/11351/8519
Access Level:Open access
Keyword:Chagas, Malaltia de - Diagnòstic
DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease
Other subheadings::Other subheadings::/diagnosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Tests, Routine
ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas
Otros calificadores::Otros calificadores::/diagnóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::pruebas diagnósticas rutinarias
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/8519
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
title Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
spellingShingle Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
Suescún-Carrero, Sandra Helena
Chagas, Malaltia de - Diagnòstic
DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease
Other subheadings::Other subheadings::/diagnosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Tests, Routine
ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas
Otros calificadores::Otros calificadores::/diagnóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::pruebas diagnósticas rutinarias
title_short Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
title_full Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
title_fullStr Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
title_full_unstemmed Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
title_sort Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
dc.creator.none.fl_str_mv Suescún-Carrero, Sandra Helena
Tadger, Philippe
Sandoval-Cuellar, Carolina
Armadans, Lluis
Ramirez Lopez, Laura Ximena
author Suescún-Carrero, Sandra Helena
author_facet Suescún-Carrero, Sandra Helena
Tadger, Philippe
Sandoval-Cuellar, Carolina
Armadans, Lluis
Ramirez Lopez, Laura Ximena
author_role author
author2 Tadger, Philippe
Sandoval-Cuellar, Carolina
Armadans, Lluis
Ramirez Lopez, Laura Ximena
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Suescún-Carrero SH, Sandoval Cuellar C, Ramírez López LX] Universidad de Boyacá, Tunja, Colombia. [Tadger P] Universidad de Boyacá, Tunja, Colombia. Real World Solutions, IQVIA, Zaventem, Belgium. [Armadans-Gil L] Servei de Medicina Preventiva i Epidemiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Chagas, Malaltia de - Diagnòstic
DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease
Other subheadings::Other subheadings::/diagnosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Tests, Routine
ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas
Otros calificadores::Otros calificadores::/diagnóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::pruebas diagnósticas rutinarias
topic Chagas, Malaltia de - Diagnòstic
DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease
Other subheadings::Other subheadings::/diagnosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Tests, Routine
ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas
Otros calificadores::Otros calificadores::/diagnóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::pruebas diagnósticas rutinarias
description Factors de risc mèdic; Medicina diagnòstica; Tripanosoma cruzi
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8519
url https://hdl.handle.net/11351/8519
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS Neglected Tropical Diseases;16(10)
https://doi.org/10.1371/journal.pntd.0010860
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410353375346688
spelling Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysisSuescún-Carrero, Sandra HelenaTadger, PhilippeSandoval-Cuellar, CarolinaArmadans, LluisRamirez Lopez, Laura XimenaChagas, Malaltia de - DiagnòsticDISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas DiseaseOther subheadings::Other subheadings::/diagnosisANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Tests, RoutineENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de ChagasOtros calificadores::Otros calificadores::/diagnósticoTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::pruebas diagnósticas rutinariasFactors de risc mèdic; Medicina diagnòstica; Tripanosoma cruziFactores de riesgo médicos; Medicina diagnóstica; Tripanosoma cruziMedical risk factors; Diagnostic medicine; Trypanosoma cruziObjective To determine the diagnostic validity of the enzyme-linked immunosorbent assay (ELISA) and Rapid Diagnostic Tests (RDT) among individuals with suspected chronic Chagas Disease (CD). Methodology A search was made for studies with ELISA and RDT assays validity estimates as eligibility criteria, published between 2010 and 2020 on PubMed, Web of Science, Scopus, and LILACS. This way, we extracted the data and assessed the risk of bias and applicability of the studies using the QUADAS-2 tool. The bivariate random effects model was also used to estimate the overall sensitivity and specificity through forest-plots, ROC space, and we visually assessed the heterogeneity between studies. Meta-regressions were made using subgroup analysis. We used Deeks’ test to assess the risk of publication bias. Results 43 studies were included; 27 assessed ELISA tests; 14 assessed RDTs; and 2 assessed ELISA and RDTs, against different reference standards. 51.2 % of them used a non-comparative observational design, and 46.5 % a comparative clinical design (“case-control” type). High risk of bias was detected for patient screening and reference standard. The ELISA tests had a sensitivity of 99% (95% CI: 98–99) and a specificity of 98% (95% CI: 97–99); whereas the Rapid Diagnostic Tests (RDT) had values of 95% (95% CI: 94–97) and 97% (95% CI: 96–98), respectively. Deeks’ test showed asymmetry on the ELISA assays. Conclusions ELISA and RDT tests have high validity for diagnosing chronic Chagas disease. The analysis of these two types of evidence in this systematic review and meta-analysis constitutes an input for their use. The limitations included the difficulty in extracting data due to the lack of information in the articles, and the comparative clinical-type design of some studies.SHSC, LXRL, CSC, PT were funded by the Universidad de Boyacá, Colombia. LAG was funded by the Universitat Autónoma de Barcelona, Barcelona, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of ScienceInstitut Català de la Salut[Suescún-Carrero SH, Sandoval Cuellar C, Ramírez López LX] Universidad de Boyacá, Tunja, Colombia. [Tadger P] Universidad de Boyacá, Tunja, Colombia. Real World Solutions, IQVIA, Zaventem, Belgium. [Armadans-Gil L] Servei de Medicina Preventiva i Epidemiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8519Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésPLoS Neglected Tropical Diseases;16(10)https://doi.org/10.1371/journal.pntd.0010860Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/85192026-06-12T09:38:37Z
score 15,812429

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