RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity

[eng] OBJECTIVES: In this thesis we aim to demonstrate that Rank expression in tumour or myeloid cells promotes an immunosuppressive microenvironment that favours the tumour onset and progression. To address this hypothesis, the specific objectives are: 1. To determine how RANK expression in breast...

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Detalles Bibliográficos
Autor: Barranco López, Alexandra
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/217352
Acceso en línea:https://hdl.handle.net/2445/217352
http://hdl.handle.net/10803/693296
Access Level:acceso abierto
Palabra clave:Càncer de mama
Macròfags
Immunoteràpia
Breast cancer
Macrophages
Immunotheraphy
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spelling RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunityBarranco López, AlexandraCàncer de mamaMacròfagsImmunoteràpiaBreast cancerMacrophagesImmunotheraphy[eng] OBJECTIVES: In this thesis we aim to demonstrate that Rank expression in tumour or myeloid cells promotes an immunosuppressive microenvironment that favours the tumour onset and progression. To address this hypothesis, the specific objectives are: 1. To determine how RANK expression in breast cancer cells regulates the tumour-immune response and tumour onset. 1.1 To evaluate the intrinsic effects of the loss of Rank expression in tumour cells in an immunodeficient environment. 1.2 To evaluate how Rank overexpression in tumour cells regulates the tumour- immune crosstalk in breast cancer. 2. To determine whether and how RANK expression in macrophages regulates the tumour-immune response and its therapeutic impact on breast cancer. 2.1 To investigate the role of RANK in macrophage differentiation and activation. 2.2 To evaluate whether the loss of Rank expression in macrophages modulates its functionality in a tumour setting and its implication in breast cancer. 2.3 To evaluate the therapeutic benefit of the systemic inhibition of Rank signalling and its impact on macrophage functionality.Universitat de BarcelonaGonzález Suárez, EvaPérez Chacón, GemaUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut2024info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/217352http://hdl.handle.net/10803/693296Tesis Doctorals - Facultat - Medicina i Ciències de la Salutreponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglés(c) Barranco López, Alexandra, 2025info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2173522026-05-27T06:46:51Z
dc.title.none.fl_str_mv RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
title RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
spellingShingle RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
Barranco López, Alexandra
Càncer de mama
Macròfags
Immunoteràpia
Breast cancer
Macrophages
Immunotheraphy
title_short RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
title_full RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
title_fullStr RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
title_full_unstemmed RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
title_sort RANK pathway as a key regulator of the tumour-immune crosstalk and tumour immunity
dc.creator.none.fl_str_mv Barranco López, Alexandra
author Barranco López, Alexandra
author_facet Barranco López, Alexandra
author_role author
dc.contributor.none.fl_str_mv González Suárez, Eva
Pérez Chacón, Gema
Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.subject.none.fl_str_mv Càncer de mama
Macròfags
Immunoteràpia
Breast cancer
Macrophages
Immunotheraphy
topic Càncer de mama
Macròfags
Immunoteràpia
Breast cancer
Macrophages
Immunotheraphy
description [eng] OBJECTIVES: In this thesis we aim to demonstrate that Rank expression in tumour or myeloid cells promotes an immunosuppressive microenvironment that favours the tumour onset and progression. To address this hypothesis, the specific objectives are: 1. To determine how RANK expression in breast cancer cells regulates the tumour-immune response and tumour onset. 1.1 To evaluate the intrinsic effects of the loss of Rank expression in tumour cells in an immunodeficient environment. 1.2 To evaluate how Rank overexpression in tumour cells regulates the tumour- immune crosstalk in breast cancer. 2. To determine whether and how RANK expression in macrophages regulates the tumour-immune response and its therapeutic impact on breast cancer. 2.1 To investigate the role of RANK in macrophage differentiation and activation. 2.2 To evaluate whether the loss of Rank expression in macrophages modulates its functionality in a tumour setting and its implication in breast cancer. 2.3 To evaluate the therapeutic benefit of the systemic inhibition of Rank signalling and its impact on macrophage functionality.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/217352
http://hdl.handle.net/10803/693296
url https://hdl.handle.net/2445/217352
http://hdl.handle.net/10803/693296
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv (c) Barranco López, Alexandra, 2025
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Barranco López, Alexandra, 2025
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv Tesis Doctorals - Facultat - Medicina i Ciències de la Salut
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410346620420096
score 15,812429

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