Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives

Martelli, Valentino; Vidal, Joana; Salvans Ruiz, Silvia; Fernández, Concepción; Badia-Ramentol, Jordi; Linares, Jenniffer; Jiménez Gómez, Marta; Sibilio, Annarita; Gibert Fernandez, Joan, 1988-; Pérez, Marina; Bellosillo Paricio, Beatriz; Calon, Alexandre; Pietrantonio, Filippo; Iglesias Coma, Mar; Pascual Damieta, Marta; Montagut Viladot, Clara

Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives

Peritoneal carcinomatosis from colorectal cancer (PC-CRC) is a challenging condition associated with poor outcomes, even with aggressive treatments like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). One of the main challenges is the lack of reliable biomarkers to...

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Autores:	Martelli, Valentino, Vidal, Joana, Salvans Ruiz, Silvia, Fernández, Concepción, Badia-Ramentol, Jordi, Linares, Jenniffer, Jiménez Gómez, Marta, Sibilio, Annarita, Gibert Fernandez, Joan, 1988-, Pérez, Marina, Bellosillo Paricio, Beatriz, Calon, Alexandre, Pietrantonio, Filippo, Iglesias Coma, Mar, Pascual Damieta, Marta, Montagut Viladot, Clara
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:dnet:recercat____::a21d4b105f3b32c33f26256ec61b47cc
Acceso en línea:	https://hdl.handle.net/10230/72978 http://dx.doi.org/10.3390/cancers17091461
Access Level:	acceso abierto
Palabra clave:	Circulating tumor DNA Metastatic colorectal cancer Peritoneal carcinomatosis Peritoneal tumor DNA Precision medicine

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spelling	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectivesMartelli, ValentinoVidal, JoanaSalvans Ruiz, SilviaFernández, ConcepciónBadia-Ramentol, JordiLinares, JennifferJiménez Gómez, MartaSibilio, AnnaritaGibert Fernandez, Joan, 1988-Pérez, MarinaBellosillo Paricio, BeatrizCalon, AlexandrePietrantonio, FilippoIglesias Coma, MarPascual Damieta, MartaMontagut Viladot, ClaraCirculating tumor DNAMetastatic colorectal cancerPeritoneal carcinomatosisPeritoneal tumor DNAPrecision medicinePeritoneal carcinomatosis from colorectal cancer (PC-CRC) is a challenging condition associated with poor outcomes, even with aggressive treatments like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). One of the main challenges is the lack of reliable biomarkers to guide personalized treatment decisions. Circulating tumor DNA (ctDNA) in plasma has recently emerged as a promising tool in colorectal cancer (CRC) management. It detects residual disease after surgery in early-stage CRC and tracks mutations, treatment response, and resistance in metastatic CRC (mCRC). For PC-CRC, ctDNA, along with peritoneal tumor DNA (ptDNA) detected in peritoneal fluid, could offer significant insights for guiding treatment. These biomarkers have potential to improve disease monitoring and outcomes in this challenging context. This review examines the strengths, limitations, and future applications of liquid biopsy for PC-CRC care.MDPI2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72978http://dx.doi.org/10.3390/cancers17091461https://hdl.handle.net/10230/72978reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCancers. 2025;17(9):1461© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::a21d4b105f3b32c33f26256ec61b47cc2026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
title	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
spellingShingle	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives Martelli, Valentino Circulating tumor DNA Metastatic colorectal cancer Peritoneal carcinomatosis Peritoneal tumor DNA Precision medicine
title_short	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
title_full	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
title_fullStr	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
title_full_unstemmed	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
title_sort	Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives
dc.creator.none.fl_str_mv	Martelli, Valentino Vidal, Joana Salvans Ruiz, Silvia Fernández, Concepción Badia-Ramentol, Jordi Linares, Jenniffer Jiménez Gómez, Marta Sibilio, Annarita Gibert Fernandez, Joan, 1988- Pérez, Marina Bellosillo Paricio, Beatriz Calon, Alexandre Pietrantonio, Filippo Iglesias Coma, Mar Pascual Damieta, Marta Montagut Viladot, Clara
author	Martelli, Valentino
author_facet	Martelli, Valentino Vidal, Joana Salvans Ruiz, Silvia Fernández, Concepción Badia-Ramentol, Jordi Linares, Jenniffer Jiménez Gómez, Marta Sibilio, Annarita Gibert Fernandez, Joan, 1988- Pérez, Marina Bellosillo Paricio, Beatriz Calon, Alexandre Pietrantonio, Filippo Iglesias Coma, Mar Pascual Damieta, Marta Montagut Viladot, Clara
author_role	author
author2	Vidal, Joana Salvans Ruiz, Silvia Fernández, Concepción Badia-Ramentol, Jordi Linares, Jenniffer Jiménez Gómez, Marta Sibilio, Annarita Gibert Fernandez, Joan, 1988- Pérez, Marina Bellosillo Paricio, Beatriz Calon, Alexandre Pietrantonio, Filippo Iglesias Coma, Mar Pascual Damieta, Marta Montagut Viladot, Clara
author2_role	author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Circulating tumor DNA Metastatic colorectal cancer Peritoneal carcinomatosis Peritoneal tumor DNA Precision medicine
topic	Circulating tumor DNA Metastatic colorectal cancer Peritoneal carcinomatosis Peritoneal tumor DNA Precision medicine
description	Peritoneal carcinomatosis from colorectal cancer (PC-CRC) is a challenging condition associated with poor outcomes, even with aggressive treatments like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). One of the main challenges is the lack of reliable biomarkers to guide personalized treatment decisions. Circulating tumor DNA (ctDNA) in plasma has recently emerged as a promising tool in colorectal cancer (CRC) management. It detects residual disease after surgery in early-stage CRC and tracks mutations, treatment response, and resistance in metastatic CRC (mCRC). For PC-CRC, ctDNA, along with peritoneal tumor DNA (ptDNA) detected in peritoneal fluid, could offer significant insights for guiding treatment. These biomarkers have potential to improve disease monitoring and outcomes in this challenging context. This review examines the strengths, limitations, and future applications of liquid biopsy for PC-CRC care.
publishDate	2025
dc.date.none.fl_str_mv	2025 2026 2026 2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10230/72978 http://dx.doi.org/10.3390/cancers17091461 https://hdl.handle.net/10230/72978
url	https://hdl.handle.net/10230/72978 http://dx.doi.org/10.3390/cancers17091461
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Cancers. 2025;17(9):1461
dc.rights.none.fl_str_mv	http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Liquid biopsy in peritoneal carcinomatosis from colorectal cancer: current evidence and future perspectives

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