Endothelial progenitor cells in acute ischemic stroke

Objectives: The levels of circulating endothelial progenitor cells (EPCs) in ischemic stroke have not been studied extensively and reported results are inconsistent. We aimed to investigate the time course, the prognostic relevance, and the variables associated with EPC counts in patients with ische...

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Autores: Marti-Fabregas, J, Crespo, J, Delgado-Mederos, R, Martinez-Ramirez, S, Pena, E, Marin, R, Dinia, L, Jimenez-Xarrie, E, Fernandez-Arcos, A, Perez-Perez, J, Querol, L, Suarez-Calvet, M, Badimon, L
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p9576
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9576
Access Level:acceso abierto
Palabra clave:Endothelial progenitor cells
ischemic stroke
statin
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spelling Endothelial progenitor cells in acute ischemic strokeMarti-Fabregas, JCrespo, JDelgado-Mederos, RMartinez-Ramirez, SPena, EMarin, RDinia, LJimenez-Xarrie, EFernandez-Arcos, APerez-Perez, JQuerol, LSuarez-Calvet, MBadimon, LEndothelial progenitor cellsischemic strokestatinObjectives: The levels of circulating endothelial progenitor cells (EPCs) in ischemic stroke have not been studied extensively and reported results are inconsistent. We aimed to investigate the time course, the prognostic relevance, and the variables associated with EPC counts in patients with ischemic stroke at different time points. Material and methods: We studied prospectively 146 consecutive patients with ischemic stroke within the first 48 h from the onset of symptoms (baseline). We evaluated demographic data, classical vascular risk factors, treatment with thrombolysis and statins, stroke etiology, National Institute of Health and Stroke Scale score and outcome (favorable when Rankin scale score (0-2). Blood samples were collected at baseline, at day 7 after stroke (n = 121) and at 3 months (n = 92). The EPC were measured by flow cytometry. Results: We included 146 patients with a mean age of 70.8 +/- 12.2 years. The circulating EPC levels were higher on day 7 than at baseline or at 3 months (P = 0.045). Pretreatment with statins (odds ratio [OR] 3.11, P = 0.008) and stroke etiology (P = 0.032) were predictive of EPC counts in the baseline sample. EPC counts were not associated with stroke severity or functional outcome in all the patients. However, using multivariate analyses, a better functional outcome was found in patients with higher EPC counts in large-artery atherosclerosis and small-vessel disease etiologic subtypes. Conclusions: After acute ischemic stroke, circulating EPC counts peaked at day 7. Pretreatment with statins increased the levels of EPC. In patients with large-artery atherosclerosis and small-vessel disease subtypes, higher counts were related to better outcome at 3 months.WILEY2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9576Brain and BehaviorISSN: 21623279reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p95762026-06-14T12:41:47Z
dc.title.none.fl_str_mv Endothelial progenitor cells in acute ischemic stroke
title Endothelial progenitor cells in acute ischemic stroke
spellingShingle Endothelial progenitor cells in acute ischemic stroke
Marti-Fabregas, J
Endothelial progenitor cells
ischemic stroke
statin
title_short Endothelial progenitor cells in acute ischemic stroke
title_full Endothelial progenitor cells in acute ischemic stroke
title_fullStr Endothelial progenitor cells in acute ischemic stroke
title_full_unstemmed Endothelial progenitor cells in acute ischemic stroke
title_sort Endothelial progenitor cells in acute ischemic stroke
dc.creator.none.fl_str_mv Marti-Fabregas, J
Crespo, J
Delgado-Mederos, R
Martinez-Ramirez, S
Pena, E
Marin, R
Dinia, L
Jimenez-Xarrie, E
Fernandez-Arcos, A
Perez-Perez, J
Querol, L
Suarez-Calvet, M
Badimon, L
author Marti-Fabregas, J
author_facet Marti-Fabregas, J
Crespo, J
Delgado-Mederos, R
Martinez-Ramirez, S
Pena, E
Marin, R
Dinia, L
Jimenez-Xarrie, E
Fernandez-Arcos, A
Perez-Perez, J
Querol, L
Suarez-Calvet, M
Badimon, L
author_role author
author2 Crespo, J
Delgado-Mederos, R
Martinez-Ramirez, S
Pena, E
Marin, R
Dinia, L
Jimenez-Xarrie, E
Fernandez-Arcos, A
Perez-Perez, J
Querol, L
Suarez-Calvet, M
Badimon, L
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endothelial progenitor cells
ischemic stroke
statin
topic Endothelial progenitor cells
ischemic stroke
statin
description Objectives: The levels of circulating endothelial progenitor cells (EPCs) in ischemic stroke have not been studied extensively and reported results are inconsistent. We aimed to investigate the time course, the prognostic relevance, and the variables associated with EPC counts in patients with ischemic stroke at different time points. Material and methods: We studied prospectively 146 consecutive patients with ischemic stroke within the first 48 h from the onset of symptoms (baseline). We evaluated demographic data, classical vascular risk factors, treatment with thrombolysis and statins, stroke etiology, National Institute of Health and Stroke Scale score and outcome (favorable when Rankin scale score (0-2). Blood samples were collected at baseline, at day 7 after stroke (n = 121) and at 3 months (n = 92). The EPC were measured by flow cytometry. Results: We included 146 patients with a mean age of 70.8 +/- 12.2 years. The circulating EPC levels were higher on day 7 than at baseline or at 3 months (P = 0.045). Pretreatment with statins (odds ratio [OR] 3.11, P = 0.008) and stroke etiology (P = 0.032) were predictive of EPC counts in the baseline sample. EPC counts were not associated with stroke severity or functional outcome in all the patients. However, using multivariate analyses, a better functional outcome was found in patients with higher EPC counts in large-artery atherosclerosis and small-vessel disease etiologic subtypes. Conclusions: After acute ischemic stroke, circulating EPC counts peaked at day 7. Pretreatment with statins increased the levels of EPC. In patients with large-artery atherosclerosis and small-vessel disease subtypes, higher counts were related to better outcome at 3 months.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9576
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9576
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Brain and Behavior
ISSN: 21623279
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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