RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

Mechanistic target of Rapamycin (mTOR) pathway regulates essential processes directed to preserve cellular homeostasis, such as cell growth, proliferation, survival, protein synthesis and autophagy. Importantly, mTOR pathway deregulation has been related to many diseases. Indeed, it has become a hal...

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Autores: Canal de la Iglesia, Mercè, Romaní Aumedes, Joan, Martín Flores, Núria, Pérez Fernández, Víctor, Malagelada Grau, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/120879
Acceso en línea:https://hdl.handle.net/2445/120879
Access Level:acceso abierto
Palabra clave:Malalties neurodegeneratives
Degeneració (Patologia)
Malaltia de Parkinson
Cicle cel·lular
Neurodegenerative Diseases
Degeneration (Pathology)
Parkinson's disease
Cell cycle
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spelling RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disordersCanal de la Iglesia, MercèRomaní Aumedes, JoanMartín Flores, NúriaPérez Fernández, VíctorMalagelada Grau, CristinaMalalties neurodegenerativesDegeneració (Patologia)Malaltia de ParkinsonCicle cel·lularNeurodegenerative DiseasesDegeneration (Pathology)Parkinson's diseaseCell cycleMechanistic target of Rapamycin (mTOR) pathway regulates essential processes directed to preserve cellular homeostasis, such as cell growth, proliferation, survival, protein synthesis and autophagy. Importantly, mTOR pathway deregulation has been related to many diseases. Indeed, it has become a hallmark in neurodegenerative disorders, since a fine-tuned regulation of mTOR activities is crucial for neuron function and survival. RTP801/REDD1/Dig2 has become one of the most puzzling regulators of mTOR. Although the mechanism is not completely understood, RTP801 inactivates mTOR and Akt via the tuberous sclerosis complex (TSC1/TSC2) in many cellular contexts. Intriguingly, RTP801 protects dividing cells from hypoxia or H2O2-induced apoptosis, while it sensitizes differentiated cells to stress. Based on experimental models of Parkinson's disease (PD), it has been proposed that at early stages of the disease, stress-induced RTP801 upregulation contributes to mTOR repression, in an attempt to maintain cell function and viability. However, if RTP801 elevation is sustained, it leads to neuron cell death by a sequential inhibition of mTOR and Akt. Here, we will review RTP801 deregulation of mTOR in a context of PD and other neurodegenerative disorders.Frontiers Media2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/120879Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fncel.2014.00313Frontiers in Cellular Neuroscience, 2014, vol. 8, num. 313https://doi.org/10.3389/fncel.2014.00313info:eu-repo/grantAgreement/EC/FP7/276957cc-by (c) Canal de la Iglesia et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1208792026-05-27T06:46:51Z
dc.title.none.fl_str_mv RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
title RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
spellingShingle RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
Canal de la Iglesia, Mercè
Malalties neurodegeneratives
Degeneració (Patologia)
Malaltia de Parkinson
Cicle cel·lular
Neurodegenerative Diseases
Degeneration (Pathology)
Parkinson's disease
Cell cycle
title_short RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
title_full RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
title_fullStr RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
title_full_unstemmed RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
title_sort RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders
dc.creator.none.fl_str_mv Canal de la Iglesia, Mercè
Romaní Aumedes, Joan
Martín Flores, Núria
Pérez Fernández, Víctor
Malagelada Grau, Cristina
author Canal de la Iglesia, Mercè
author_facet Canal de la Iglesia, Mercè
Romaní Aumedes, Joan
Martín Flores, Núria
Pérez Fernández, Víctor
Malagelada Grau, Cristina
author_role author
author2 Romaní Aumedes, Joan
Martín Flores, Núria
Pérez Fernández, Víctor
Malagelada Grau, Cristina
author2_role author
author
author
author
dc.subject.none.fl_str_mv Malalties neurodegeneratives
Degeneració (Patologia)
Malaltia de Parkinson
Cicle cel·lular
Neurodegenerative Diseases
Degeneration (Pathology)
Parkinson's disease
Cell cycle
topic Malalties neurodegeneratives
Degeneració (Patologia)
Malaltia de Parkinson
Cicle cel·lular
Neurodegenerative Diseases
Degeneration (Pathology)
Parkinson's disease
Cell cycle
description Mechanistic target of Rapamycin (mTOR) pathway regulates essential processes directed to preserve cellular homeostasis, such as cell growth, proliferation, survival, protein synthesis and autophagy. Importantly, mTOR pathway deregulation has been related to many diseases. Indeed, it has become a hallmark in neurodegenerative disorders, since a fine-tuned regulation of mTOR activities is crucial for neuron function and survival. RTP801/REDD1/Dig2 has become one of the most puzzling regulators of mTOR. Although the mechanism is not completely understood, RTP801 inactivates mTOR and Akt via the tuberous sclerosis complex (TSC1/TSC2) in many cellular contexts. Intriguingly, RTP801 protects dividing cells from hypoxia or H2O2-induced apoptosis, while it sensitizes differentiated cells to stress. Based on experimental models of Parkinson's disease (PD), it has been proposed that at early stages of the disease, stress-induced RTP801 upregulation contributes to mTOR repression, in an attempt to maintain cell function and viability. However, if RTP801 elevation is sustained, it leads to neuron cell death by a sequential inhibition of mTOR and Akt. Here, we will review RTP801 deregulation of mTOR in a context of PD and other neurodegenerative disorders.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120879
url https://hdl.handle.net/2445/120879
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fncel.2014.00313
Frontiers in Cellular Neuroscience, 2014, vol. 8, num. 313
https://doi.org/10.3389/fncel.2014.00313
info:eu-repo/grantAgreement/EC/FP7/276957
dc.rights.none.fl_str_mv cc-by (c) Canal de la Iglesia et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Canal de la Iglesia et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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