HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease

HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such as cornea, endothelial and erythroid precursors...

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Autores: Martín Villa, José Manuel, Juárez Martín-Delgado, Ignacio, Fernández-Cruz Pérez, Eduardo, Arnaiz Villena, Antonio, Vaquero-Yuste, Christian, Molina-Alejandre, Marta, Suárez-Trujillo, Fabio, López-Nares, Adrián, Palacio‐Gruber, José, Barrera-Gutiérrez, Luis, Rodríguez-Sainz, Carmen
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/92340
Acceso en línea:https://hdl.handle.net/20.500.14352/92340
Access Level:acceso abierto
Palabra clave:612.017
Inmunología
2412 Inmunología
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spelling HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune DiseaseMartín Villa, José ManuelJuárez Martín-Delgado, IgnacioFernández-Cruz Pérez, EduardoArnaiz Villena, AntonioVaquero-Yuste, ChristianMolina-Alejandre, MartaSuárez-Trujillo, FabioLópez-Nares, AdriánPalacio‐Gruber, JoséBarrera-Gutiérrez, LuisRodríguez-Sainz, Carmen612.017Inmunología2412 InmunologíaHLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such as cornea, endothelial and erythroid precursors, and thymus. The immunosuppressive effect of HLA-G is exerted through the interaction with its cognate receptors, expressed on immunocompetent cells, like ILT2, expressed on NK, B, T cells and APCs; ILT4, on APCs; KIR, found on the surface of NK cells; and finally, the co-receptor CD8. Because of these immunomodulatory functions, HLA-G has been involved in several processes, amongst which organ transplantation, viral infections, cancer progression, and autoimmunity. HLA-G neo-expression on tumors has been recently described in several types of malignancies. In fact, tumor progression is tightly linked to the presence of the molecule, as it exerts its tolerogenic function, inhibiting the cells of the immune system and favoring tumor escape. Several polymorphisms in the 3’UTR region condition changes in HLA-G expression (14bp and +3142C/G, among others), which have been associated with both the development and outcome of patients with different tumor types. Also, in recent years, several studies have shown that HLA-G plays an important role in the control of autoimmune diseases. The ability of HLA-G to limit the progression of these diseases has been confirmed and, in fact, levels of the molecule and several of its polymorphisms have been associated with increased susceptibility to the development of autoimmune diseases, as well as increased disease severity. Thus, modulating HLA-G expression in target tissues of oncology patients or patients with autoimmune diseases may be potential therapeutic approaches to treat these pathological conditions.FrontiersUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/92340reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/923402026-06-02T12:44:21Z
dc.title.none.fl_str_mv HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
title HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
spellingShingle HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
Martín Villa, José Manuel
612.017
Inmunología
2412 Inmunología
title_short HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
title_full HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
title_fullStr HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
title_full_unstemmed HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
title_sort HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease
dc.creator.none.fl_str_mv Martín Villa, José Manuel
Juárez Martín-Delgado, Ignacio
Fernández-Cruz Pérez, Eduardo
Arnaiz Villena, Antonio
Vaquero-Yuste, Christian
Molina-Alejandre, Marta
Suárez-Trujillo, Fabio
López-Nares, Adrián
Palacio‐Gruber, José
Barrera-Gutiérrez, Luis
Rodríguez-Sainz, Carmen
author Martín Villa, José Manuel
author_facet Martín Villa, José Manuel
Juárez Martín-Delgado, Ignacio
Fernández-Cruz Pérez, Eduardo
Arnaiz Villena, Antonio
Vaquero-Yuste, Christian
Molina-Alejandre, Marta
Suárez-Trujillo, Fabio
López-Nares, Adrián
Palacio‐Gruber, José
Barrera-Gutiérrez, Luis
Rodríguez-Sainz, Carmen
author_role author
author2 Juárez Martín-Delgado, Ignacio
Fernández-Cruz Pérez, Eduardo
Arnaiz Villena, Antonio
Vaquero-Yuste, Christian
Molina-Alejandre, Marta
Suárez-Trujillo, Fabio
López-Nares, Adrián
Palacio‐Gruber, José
Barrera-Gutiérrez, Luis
Rodríguez-Sainz, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.017
Inmunología
2412 Inmunología
topic 612.017
Inmunología
2412 Inmunología
description HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such as cornea, endothelial and erythroid precursors, and thymus. The immunosuppressive effect of HLA-G is exerted through the interaction with its cognate receptors, expressed on immunocompetent cells, like ILT2, expressed on NK, B, T cells and APCs; ILT4, on APCs; KIR, found on the surface of NK cells; and finally, the co-receptor CD8. Because of these immunomodulatory functions, HLA-G has been involved in several processes, amongst which organ transplantation, viral infections, cancer progression, and autoimmunity. HLA-G neo-expression on tumors has been recently described in several types of malignancies. In fact, tumor progression is tightly linked to the presence of the molecule, as it exerts its tolerogenic function, inhibiting the cells of the immune system and favoring tumor escape. Several polymorphisms in the 3’UTR region condition changes in HLA-G expression (14bp and +3142C/G, among others), which have been associated with both the development and outcome of patients with different tumor types. Also, in recent years, several studies have shown that HLA-G plays an important role in the control of autoimmune diseases. The ability of HLA-G to limit the progression of these diseases has been confirmed and, in fact, levels of the molecule and several of its polymorphisms have been associated with increased susceptibility to the development of autoimmune diseases, as well as increased disease severity. Thus, modulating HLA-G expression in target tissues of oncology patients or patients with autoimmune diseases may be potential therapeutic approaches to treat these pathological conditions.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/92340
url https://hdl.handle.net/20.500.14352/92340
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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