Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications

Vegliante, M.C. (Maria Carmela)|||/items/1d0c2904-264c-495d-add5-0e0443879d39; Royo, C. (Cristina)|||/items/058649bb-d99b-45c1-8732-7df63d3e30fa; Palomero, J. (Jara)|||/items/9a4a76fc-322d-434a-88d5-436ba26b1df2; Salaverria-Lete, I. (Itziar)|||/items/b7c06977-13e2-4b97-ab8e-12f574fe390d; Balint, B. (Balazs)|||/items/a88bcab2-2206-4470-952f-eb89dcdac9a1; Martin-Guerrero, I. (Idoia)|||/items/75058248-45e7-4a0d-846a-c54070403a95; Aguirre-Ena, X. (Xabier)|||/items/2a000d9c-cb5c-4734-a32c-4fef79998c86; Lujambio, A. (Amaya)|||/items/30897a02-ab11-452c-bfb3-5017a80b4b07; Richter, J. (Julia)|||/items/9b8ed160-d794-42ab-bc11-d8b399958903; Xargay-Torrent, S. (Silvia)|||/items/41036eac-3771-4268-8375-c6c6dee98ed5; Bea, S. (Silvia)|||/items/dd8e55ec-3769-42cb-a863-7efcb1a6ff99; Hernandez, L. (Luis)|||/items/2c9fde05-e428-49d0-b501-073eb1685b69; Enjuanes, A. (Anna)|||/items/ae05b1da-7dee-458f-ae3a-5e0df9f13517; Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086; Rosenwald, A. (Andreas)|||/items/b8416f72-eaa3-4506-9122-d26f09543bc5; Ott, G. (German)|||/items/cc0e7dca-cf20-4cf2-87ce-bfa79bbd12de; Roman-Gomez, J. (José)|||/items/bca25c5c-f92e-4fe2-b9a3-4b722345de85; Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1; Esteller, M. (Manel)|||/items/0124804c-ffb7-4533-a07c-de3aa1c30a07; Jares, P. (Pedro)|||/items/e5008b62-4b91-4ec7-a0c4-bbd1a278682b; Siebert, R. (Reiner)|||/items/bdb7bfa7-0211-4a62-b287-3b78c803227b; Campo, E. (Elías)|||/items/aacb9b6b-0d39-464b-830a-96cd8b6dada2; Martin-Subero, J.I. (Jose Ignacio)|||/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824; Amador, V. (Virginia)|||/items/c24bc096-3e4c-4bf7-bd19-0de13339a859

Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications

Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells and different...

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Detalles Bibliográficos
Autores:	Vegliante, M.C. (Maria Carmela)\|\|\|/items/1d0c2904-264c-495d-add5-0e0443879d39, Royo, C. (Cristina)\|\|\|/items/058649bb-d99b-45c1-8732-7df63d3e30fa, Palomero, J. (Jara)\|\|\|/items/9a4a76fc-322d-434a-88d5-436ba26b1df2, Salaverria-Lete, I. (Itziar)\|\|\|/items/b7c06977-13e2-4b97-ab8e-12f574fe390d, Balint, B. (Balazs)\|\|\|/items/a88bcab2-2206-4470-952f-eb89dcdac9a1, Martin-Guerrero, I. (Idoia)\|\|\|/items/75058248-45e7-4a0d-846a-c54070403a95, Aguirre-Ena, X. (Xabier)\|\|\|/items/2a000d9c-cb5c-4734-a32c-4fef79998c86, Lujambio, A. (Amaya)\|\|\|/items/30897a02-ab11-452c-bfb3-5017a80b4b07, Richter, J. (Julia)\|\|\|/items/9b8ed160-d794-42ab-bc11-d8b399958903, Xargay-Torrent, S. (Silvia)\|\|\|/items/41036eac-3771-4268-8375-c6c6dee98ed5, Bea, S. (Silvia)\|\|\|/items/dd8e55ec-3769-42cb-a863-7efcb1a6ff99, Hernandez, L. (Luis)\|\|\|/items/2c9fde05-e428-49d0-b501-073eb1685b69, Enjuanes, A. (Anna)\|\|\|/items/ae05b1da-7dee-458f-ae3a-5e0df9f13517, Calasanz-Abinzano, M.J. (Maria Jose)\|\|\|/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086, Rosenwald, A. (Andreas)\|\|\|/items/b8416f72-eaa3-4506-9122-d26f09543bc5, Ott, G. (German)\|\|\|/items/cc0e7dca-cf20-4cf2-87ce-bfa79bbd12de, Roman-Gomez, J. (José)\|\|\|/items/bca25c5c-f92e-4fe2-b9a3-4b722345de85, Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1, Esteller, M. (Manel)\|\|\|/items/0124804c-ffb7-4533-a07c-de3aa1c30a07, Jares, P. (Pedro)\|\|\|/items/e5008b62-4b91-4ec7-a0c4-bbd1a278682b, Siebert, R. (Reiner)\|\|\|/items/bdb7bfa7-0211-4a62-b287-3b78c803227b, Campo, E. (Elías)\|\|\|/items/aacb9b6b-0d39-464b-830a-96cd8b6dada2, Martin-Subero, J.I. (Jose Ignacio)\|\|\|/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824, Amador, V. (Virginia)\|\|\|/items/c24bc096-3e4c-4bf7-bd19-0de13339a859
Tipo de recurso:	artículo
Fecha de publicación:	2011
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/35418
Acceso en línea:	https://hdl.handle.net/10171/35418
Access Level:	acceso abierto
Palabra clave:	Chromatin Immunoprecipitation DNA Methylation/drug effects Unidad de Genética clínica

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repository_id_str
spelling	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modificationsVegliante, M.C. (Maria Carmela)\|\|\|/items/1d0c2904-264c-495d-add5-0e0443879d39Royo, C. (Cristina)\|\|\|/items/058649bb-d99b-45c1-8732-7df63d3e30faPalomero, J. (Jara)\|\|\|/items/9a4a76fc-322d-434a-88d5-436ba26b1df2Salaverria-Lete, I. (Itziar)\|\|\|/items/b7c06977-13e2-4b97-ab8e-12f574fe390dBalint, B. (Balazs)\|\|\|/items/a88bcab2-2206-4470-952f-eb89dcdac9a1Martin-Guerrero, I. (Idoia)\|\|\|/items/75058248-45e7-4a0d-846a-c54070403a95Aguirre-Ena, X. (Xabier)\|\|\|/items/2a000d9c-cb5c-4734-a32c-4fef79998c86Lujambio, A. (Amaya)\|\|\|/items/30897a02-ab11-452c-bfb3-5017a80b4b07Richter, J. (Julia)\|\|\|/items/9b8ed160-d794-42ab-bc11-d8b399958903Xargay-Torrent, S. (Silvia)\|\|\|/items/41036eac-3771-4268-8375-c6c6dee98ed5Bea, S. (Silvia)\|\|\|/items/dd8e55ec-3769-42cb-a863-7efcb1a6ff99Hernandez, L. (Luis)\|\|\|/items/2c9fde05-e428-49d0-b501-073eb1685b69Enjuanes, A. (Anna)\|\|\|/items/ae05b1da-7dee-458f-ae3a-5e0df9f13517Calasanz-Abinzano, M.J. (Maria Jose)\|\|\|/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086Rosenwald, A. (Andreas)\|\|\|/items/b8416f72-eaa3-4506-9122-d26f09543bc5Ott, G. (German)\|\|\|/items/cc0e7dca-cf20-4cf2-87ce-bfa79bbd12deRoman-Gomez, J. (José)\|\|\|/items/bca25c5c-f92e-4fe2-b9a3-4b722345de85Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1Esteller, M. (Manel)\|\|\|/items/0124804c-ffb7-4533-a07c-de3aa1c30a07Jares, P. (Pedro)\|\|\|/items/e5008b62-4b91-4ec7-a0c4-bbd1a278682bSiebert, R. (Reiner)\|\|\|/items/bdb7bfa7-0211-4a62-b287-3b78c803227bCampo, E. (Elías)\|\|\|/items/aacb9b6b-0d39-464b-830a-96cd8b6dada2Martin-Subero, J.I. (Jose Ignacio)\|\|\|/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824Amador, V. (Virginia)\|\|\|/items/c24bc096-3e4c-4bf7-bd19-0de13339a859Chromatin ImmunoprecipitationDNA Methylation/drug effectsUnidad de Genética clínicaRecent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells and different lymphoid neoplasms. We observed that SOX11 expression is associated with unmethylated DNA and presence of activating histone marks (H3K9/14Ac and H3K4me3) in embryonic stem cells and some aggressive B-cell neoplasms. In contrast, adult stem cells, normal hematopoietic cells and other lymphoid neoplasms do not express SOX11. Such repression was associated with silencing histone marks H3K9me2 and H3K27me3. The SOX11 promoter of non-malignant cells was consistently unmethylated whereas lymphoid neoplasms with silenced SOX11 tended to acquire DNA hypermethylation. SOX11 silencing in cell lines was reversed by the histone deacetylase inhibitor SAHA but not by the DNA methyltransferase inhibitor AZA. These data indicate that, although DNA hypermethylation of SOX11 is frequent in lymphoid neoplasms, it seems to be functionally inert, as SOX11 is already silenced in the hematopoietic system. In contrast, the pathogenic role of SOX11 is associated with its de novo expression in some aggressive lymphoid malignancies, which is mediated by a shift from inactivating to activating histone modificationsPublic Library of ScienceDadun. Depósito Académico Digital Universidad de Navarra20142014-03-1020112011-01-0120112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/35418reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/354182026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
title	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
spellingShingle	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications Vegliante, M.C. (Maria Carmela)\|\|\|/items/1d0c2904-264c-495d-add5-0e0443879d39 Chromatin Immunoprecipitation DNA Methylation/drug effects Unidad de Genética clínica
title_short	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
title_full	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
title_fullStr	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
title_full_unstemmed	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
title_sort	Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
dc.creator.none.fl_str_mv	Vegliante, M.C. (Maria Carmela)\|\|\|/items/1d0c2904-264c-495d-add5-0e0443879d39 Royo, C. (Cristina)\|\|\|/items/058649bb-d99b-45c1-8732-7df63d3e30fa Palomero, J. (Jara)\|\|\|/items/9a4a76fc-322d-434a-88d5-436ba26b1df2 Salaverria-Lete, I. (Itziar)\|\|\|/items/b7c06977-13e2-4b97-ab8e-12f574fe390d Balint, B. (Balazs)\|\|\|/items/a88bcab2-2206-4470-952f-eb89dcdac9a1 Martin-Guerrero, I. (Idoia)\|\|\|/items/75058248-45e7-4a0d-846a-c54070403a95 Aguirre-Ena, X. (Xabier)\|\|\|/items/2a000d9c-cb5c-4734-a32c-4fef79998c86 Lujambio, A. (Amaya)\|\|\|/items/30897a02-ab11-452c-bfb3-5017a80b4b07 Richter, J. (Julia)\|\|\|/items/9b8ed160-d794-42ab-bc11-d8b399958903 Xargay-Torrent, S. (Silvia)\|\|\|/items/41036eac-3771-4268-8375-c6c6dee98ed5 Bea, S. (Silvia)\|\|\|/items/dd8e55ec-3769-42cb-a863-7efcb1a6ff99 Hernandez, L. (Luis)\|\|\|/items/2c9fde05-e428-49d0-b501-073eb1685b69 Enjuanes, A. (Anna)\|\|\|/items/ae05b1da-7dee-458f-ae3a-5e0df9f13517 Calasanz-Abinzano, M.J. (Maria Jose)\|\|\|/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Rosenwald, A. (Andreas)\|\|\|/items/b8416f72-eaa3-4506-9122-d26f09543bc5 Ott, G. (German)\|\|\|/items/cc0e7dca-cf20-4cf2-87ce-bfa79bbd12de Roman-Gomez, J. (José)\|\|\|/items/bca25c5c-f92e-4fe2-b9a3-4b722345de85 Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Esteller, M. (Manel)\|\|\|/items/0124804c-ffb7-4533-a07c-de3aa1c30a07 Jares, P. (Pedro)\|\|\|/items/e5008b62-4b91-4ec7-a0c4-bbd1a278682b Siebert, R. (Reiner)\|\|\|/items/bdb7bfa7-0211-4a62-b287-3b78c803227b Campo, E. (Elías)\|\|\|/items/aacb9b6b-0d39-464b-830a-96cd8b6dada2 Martin-Subero, J.I. (Jose Ignacio)\|\|\|/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824 Amador, V. (Virginia)\|\|\|/items/c24bc096-3e4c-4bf7-bd19-0de13339a859
author	Vegliante, M.C. (Maria Carmela)\|\|\|/items/1d0c2904-264c-495d-add5-0e0443879d39
author_facet	Vegliante, M.C. (Maria Carmela)\|\|\|/items/1d0c2904-264c-495d-add5-0e0443879d39 Royo, C. (Cristina)\|\|\|/items/058649bb-d99b-45c1-8732-7df63d3e30fa Palomero, J. (Jara)\|\|\|/items/9a4a76fc-322d-434a-88d5-436ba26b1df2 Salaverria-Lete, I. (Itziar)\|\|\|/items/b7c06977-13e2-4b97-ab8e-12f574fe390d Balint, B. (Balazs)\|\|\|/items/a88bcab2-2206-4470-952f-eb89dcdac9a1 Martin-Guerrero, I. (Idoia)\|\|\|/items/75058248-45e7-4a0d-846a-c54070403a95 Aguirre-Ena, X. (Xabier)\|\|\|/items/2a000d9c-cb5c-4734-a32c-4fef79998c86 Lujambio, A. (Amaya)\|\|\|/items/30897a02-ab11-452c-bfb3-5017a80b4b07 Richter, J. (Julia)\|\|\|/items/9b8ed160-d794-42ab-bc11-d8b399958903 Xargay-Torrent, S. (Silvia)\|\|\|/items/41036eac-3771-4268-8375-c6c6dee98ed5 Bea, S. (Silvia)\|\|\|/items/dd8e55ec-3769-42cb-a863-7efcb1a6ff99 Hernandez, L. (Luis)\|\|\|/items/2c9fde05-e428-49d0-b501-073eb1685b69 Enjuanes, A. (Anna)\|\|\|/items/ae05b1da-7dee-458f-ae3a-5e0df9f13517 Calasanz-Abinzano, M.J. (Maria Jose)\|\|\|/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Rosenwald, A. (Andreas)\|\|\|/items/b8416f72-eaa3-4506-9122-d26f09543bc5 Ott, G. (German)\|\|\|/items/cc0e7dca-cf20-4cf2-87ce-bfa79bbd12de Roman-Gomez, J. (José)\|\|\|/items/bca25c5c-f92e-4fe2-b9a3-4b722345de85 Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Esteller, M. (Manel)\|\|\|/items/0124804c-ffb7-4533-a07c-de3aa1c30a07 Jares, P. (Pedro)\|\|\|/items/e5008b62-4b91-4ec7-a0c4-bbd1a278682b Siebert, R. (Reiner)\|\|\|/items/bdb7bfa7-0211-4a62-b287-3b78c803227b Campo, E. (Elías)\|\|\|/items/aacb9b6b-0d39-464b-830a-96cd8b6dada2 Martin-Subero, J.I. (Jose Ignacio)\|\|\|/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824 Amador, V. (Virginia)\|\|\|/items/c24bc096-3e4c-4bf7-bd19-0de13339a859
author_role	author
author2	Royo, C. (Cristina)\|\|\|/items/058649bb-d99b-45c1-8732-7df63d3e30fa Palomero, J. (Jara)\|\|\|/items/9a4a76fc-322d-434a-88d5-436ba26b1df2 Salaverria-Lete, I. (Itziar)\|\|\|/items/b7c06977-13e2-4b97-ab8e-12f574fe390d Balint, B. (Balazs)\|\|\|/items/a88bcab2-2206-4470-952f-eb89dcdac9a1 Martin-Guerrero, I. (Idoia)\|\|\|/items/75058248-45e7-4a0d-846a-c54070403a95 Aguirre-Ena, X. (Xabier)\|\|\|/items/2a000d9c-cb5c-4734-a32c-4fef79998c86 Lujambio, A. (Amaya)\|\|\|/items/30897a02-ab11-452c-bfb3-5017a80b4b07 Richter, J. (Julia)\|\|\|/items/9b8ed160-d794-42ab-bc11-d8b399958903 Xargay-Torrent, S. (Silvia)\|\|\|/items/41036eac-3771-4268-8375-c6c6dee98ed5 Bea, S. (Silvia)\|\|\|/items/dd8e55ec-3769-42cb-a863-7efcb1a6ff99 Hernandez, L. (Luis)\|\|\|/items/2c9fde05-e428-49d0-b501-073eb1685b69 Enjuanes, A. (Anna)\|\|\|/items/ae05b1da-7dee-458f-ae3a-5e0df9f13517 Calasanz-Abinzano, M.J. (Maria Jose)\|\|\|/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Rosenwald, A. (Andreas)\|\|\|/items/b8416f72-eaa3-4506-9122-d26f09543bc5 Ott, G. (German)\|\|\|/items/cc0e7dca-cf20-4cf2-87ce-bfa79bbd12de Roman-Gomez, J. (José)\|\|\|/items/bca25c5c-f92e-4fe2-b9a3-4b722345de85 Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Esteller, M. (Manel)\|\|\|/items/0124804c-ffb7-4533-a07c-de3aa1c30a07 Jares, P. (Pedro)\|\|\|/items/e5008b62-4b91-4ec7-a0c4-bbd1a278682b Siebert, R. (Reiner)\|\|\|/items/bdb7bfa7-0211-4a62-b287-3b78c803227b Campo, E. (Elías)\|\|\|/items/aacb9b6b-0d39-464b-830a-96cd8b6dada2 Martin-Subero, J.I. (Jose Ignacio)\|\|\|/items/70f47d23-e1b8-40f5-8d85-fd72fb2f5824 Amador, V. (Virginia)\|\|\|/items/c24bc096-3e4c-4bf7-bd19-0de13339a859
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Chromatin Immunoprecipitation DNA Methylation/drug effects Unidad de Genética clínica
topic	Chromatin Immunoprecipitation DNA Methylation/drug effects Unidad de Genética clínica
description	Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells and different lymphoid neoplasms. We observed that SOX11 expression is associated with unmethylated DNA and presence of activating histone marks (H3K9/14Ac and H3K4me3) in embryonic stem cells and some aggressive B-cell neoplasms. In contrast, adult stem cells, normal hematopoietic cells and other lymphoid neoplasms do not express SOX11. Such repression was associated with silencing histone marks H3K9me2 and H3K27me3. The SOX11 promoter of non-malignant cells was consistently unmethylated whereas lymphoid neoplasms with silenced SOX11 tended to acquire DNA hypermethylation. SOX11 silencing in cell lines was reversed by the histone deacetylase inhibitor SAHA but not by the DNA methyltransferase inhibitor AZA. These data indicate that, although DNA hypermethylation of SOX11 is frequent in lymphoid neoplasms, it seems to be functionally inert, as SOX11 is already silenced in the hematopoietic system. In contrast, the pathogenic role of SOX11 is associated with its de novo expression in some aggressive lymphoid malignancies, which is mediated by a shift from inactivating to activating histone modifications
publishDate	2011
dc.date.none.fl_str_mv	2011 2011-01-01 2011 2011-01-01 2014 2014-03-10
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/35418
url	https://hdl.handle.net/10171/35418
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
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repository.mail.fl_str_mv
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Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications

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