Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review

The extracellular matrix (ECM), particularly the basement membrane (BM), is critical for the structural organization and functionality of ocular tissues. Among its core components, type IV collagen and laminin-1 play central roles in cell adhesion, polarity, differentiation, and survival. These macr...

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Detalles Bibliográficos
Autor: Sijilmassi, Ouafa
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/133683
Acceso en línea:https://hdl.handle.net/20.500.14352/133683
Access Level:acceso abierto
Palabra clave:617.7
Collagen IV Laminin-1
Extracellular matrix
Mutation
Eye diseases
Ciencias Biomédicas
32 Ciencias Médicas
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repository_id_str
spelling Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A reviewSijilmassi, Ouafa617.7Collagen IV Laminin-1Extracellular matrixMutationEye diseasesCiencias Biomédicas32 Ciencias MédicasThe extracellular matrix (ECM), particularly the basement membrane (BM), is critical for the structural organization and functionality of ocular tissues. Among its core components, type IV collagen and laminin-1 play central roles in cell adhesion, polarity, differentiation, and survival. These macromolecules are ubiquitously expressed in the cornea, lens, retina, and optic nerve, forming tissue-specific BMs that support development and homeostasis. In this review, findings on the spatial distribution and molecular roles of collagen IV and laminin-1 in the eye under physiological and pathological conditions, are summarized. Mutations in COL4A1, COL4A2, and laminin-encoding genes (LAMA1, LAMB1, LAMC1) are associated with a range of ocular disorders, including anterior segment dysgenesis, lens dystrophy, optic nerve hypoplasia, and retinal abnormalities. Furthermore, autoimmune responses targeting these BM proteins have been implicated in systemic diseases such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome, often leading to serious ocular complications. This review emphasizes the importance of ECM macromolecules in maintaining ocular integrity and highlights their potential as diagnostic biomarkers and therapeutic targets in both inherited and immune-mediated eye diseases.ElsevierUniversidad Complutense de Madrid20252025-12-0120252025-12-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/133683reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1336832026-06-02T12:44:21Z
dc.title.none.fl_str_mv Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
title Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
spellingShingle Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
Sijilmassi, Ouafa
617.7
Collagen IV Laminin-1
Extracellular matrix
Mutation
Eye diseases
Ciencias Biomédicas
32 Ciencias Médicas
title_short Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
title_full Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
title_fullStr Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
title_full_unstemmed Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
title_sort Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
dc.creator.none.fl_str_mv Sijilmassi, Ouafa
author Sijilmassi, Ouafa
author_facet Sijilmassi, Ouafa
author_role author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 617.7
Collagen IV Laminin-1
Extracellular matrix
Mutation
Eye diseases
Ciencias Biomédicas
32 Ciencias Médicas
topic 617.7
Collagen IV Laminin-1
Extracellular matrix
Mutation
Eye diseases
Ciencias Biomédicas
32 Ciencias Médicas
description The extracellular matrix (ECM), particularly the basement membrane (BM), is critical for the structural organization and functionality of ocular tissues. Among its core components, type IV collagen and laminin-1 play central roles in cell adhesion, polarity, differentiation, and survival. These macromolecules are ubiquitously expressed in the cornea, lens, retina, and optic nerve, forming tissue-specific BMs that support development and homeostasis. In this review, findings on the spatial distribution and molecular roles of collagen IV and laminin-1 in the eye under physiological and pathological conditions, are summarized. Mutations in COL4A1, COL4A2, and laminin-encoding genes (LAMA1, LAMB1, LAMC1) are associated with a range of ocular disorders, including anterior segment dysgenesis, lens dystrophy, optic nerve hypoplasia, and retinal abnormalities. Furthermore, autoimmune responses targeting these BM proteins have been implicated in systemic diseases such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome, often leading to serious ocular complications. This review emphasizes the importance of ECM macromolecules in maintaining ocular integrity and highlights their potential as diagnostic biomarkers and therapeutic targets in both inherited and immune-mediated eye diseases.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-12-01
2025
2025-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/133683
url https://hdl.handle.net/20.500.14352/133683
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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