Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats

[EN] The limited availability of drugs registered for dairy goats makes veterinarians prescribe off-label treatments with a legally established minimum safety period of seven days. The aim of this work was to verify if the exceptional use of macrolide antibiotics in dairy goats generates residues in...

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Autores: Quintanilla-Vázquez, Paloma Galicia, Beltrán Martínez, Mª Carmen|||0000-0002-5335-2179, Peris Palau, Bernardo, Rodríguez Garcia, Martín|||0000-0001-6079-9238, Molina Pons, Mª Pilar|||0000-0002-0647-8609
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/121373
Acesso em linha:https://riunet.upv.es/handle/10251/121373
Access Level:acceso abierto
Palavra-chave:Antibiotics
Macrolide
Goat s milk
Goat cheese
PRODUCCION ANIMAL
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spelling Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goatsQuintanilla-Vázquez, Paloma GaliciaBeltrán Martínez, Mª Carmen|||0000-0002-5335-2179Peris Palau, BernardoRodríguez Garcia, Martín|||0000-0001-6079-9238Molina Pons, Mª Pilar|||0000-0002-0647-8609AntibioticsMacrolideGoat s milkGoat cheesePRODUCCION ANIMAL[EN] The limited availability of drugs registered for dairy goats makes veterinarians prescribe off-label treatments with a legally established minimum safety period of seven days. The aim of this work was to verify if the exceptional use of macrolide antibiotics in dairy goats generates residues in milk and cheeses within that period. Hence, three macrolide drugs (erythromycin, tylosin and spiramycin) were administred in an in vivo experiment in dairy goats. Ripened cheeses were made from bulk milk obtained before drug administration, 24¿h after treatment, and at the end of the recommended withdrawal period. Residual amounts of erythromycin (234.9¿±¿52.7¿¿g/kg), tylosin (198.7¿±¿57.8¿¿g/kg) and spiramycin (1539.8¿±¿469.4¿¿g/kg), widely exceeding their legal maximum residue limits (MRLs) established, were detected in milk collected 24¿h after treatment, making the cheese production in most cases impossible. After the seven-day period, only spiramycin was detected in goat¿s milk (79.6¿±¿19.2¿¿g/kg) although no antibiotic residues were found in the cheeses. A withdrawal time of seven days seems suitable to guarantee milk safety after the administration of erythromycin and tylosin without any negative effects neither on the milk nor on the and cheese properties. However, given the rapid elimination of these substances, a shorter withdrawal period might be considered. For spiramycin, persisting in milk for a longer period, further studies on its pharmacokinetics in dairy goats would be recommendable to avoid a potential risk to consumer health.This work is part of the AGL-2013-45147-R funded by Ministerio de Ciencia e Innovacion (Madrid. Spain). The authors thank the 'Program of Support for Research and Development' (PAID-2014, UPV) for support P. Quintanilla PhD studies at Universitat Politecnica de Valencia.ElsevierDepartamento de Ciencia AnimalInstituto Universitario de Ciencia y Tecnología AnimalEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalMinisterio de Economía y EmpresaRepositorio Institucional de la Universitat Politècnica de València Riunet20182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/121373reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2013-45147-R TRAZABILIDAD DE LA PRESENCIA DE ANTIBIOTICOS EN LECHE, QUESO Y LACTOSUERO DE CABRAopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1213732026-06-13T07:49:27Z
dc.title.none.fl_str_mv Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
title Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
spellingShingle Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
Quintanilla-Vázquez, Paloma Galicia
Antibiotics
Macrolide
Goat s milk
Goat cheese
PRODUCCION ANIMAL
title_short Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
title_full Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
title_fullStr Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
title_full_unstemmed Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
title_sort Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats
dc.creator.none.fl_str_mv Quintanilla-Vázquez, Paloma Galicia
Beltrán Martínez, Mª Carmen|||0000-0002-5335-2179
Peris Palau, Bernardo
Rodríguez Garcia, Martín|||0000-0001-6079-9238
Molina Pons, Mª Pilar|||0000-0002-0647-8609
author Quintanilla-Vázquez, Paloma Galicia
author_facet Quintanilla-Vázquez, Paloma Galicia
Beltrán Martínez, Mª Carmen|||0000-0002-5335-2179
Peris Palau, Bernardo
Rodríguez Garcia, Martín|||0000-0001-6079-9238
Molina Pons, Mª Pilar|||0000-0002-0647-8609
author_role author
author2 Beltrán Martínez, Mª Carmen|||0000-0002-5335-2179
Peris Palau, Bernardo
Rodríguez Garcia, Martín|||0000-0001-6079-9238
Molina Pons, Mª Pilar|||0000-0002-0647-8609
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ciencia Animal
Instituto Universitario de Ciencia y Tecnología Animal
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
Ministerio de Economía y Empresa
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Antibiotics
Macrolide
Goat s milk
Goat cheese
PRODUCCION ANIMAL
topic Antibiotics
Macrolide
Goat s milk
Goat cheese
PRODUCCION ANIMAL
description [EN] The limited availability of drugs registered for dairy goats makes veterinarians prescribe off-label treatments with a legally established minimum safety period of seven days. The aim of this work was to verify if the exceptional use of macrolide antibiotics in dairy goats generates residues in milk and cheeses within that period. Hence, three macrolide drugs (erythromycin, tylosin and spiramycin) were administred in an in vivo experiment in dairy goats. Ripened cheeses were made from bulk milk obtained before drug administration, 24¿h after treatment, and at the end of the recommended withdrawal period. Residual amounts of erythromycin (234.9¿±¿52.7¿¿g/kg), tylosin (198.7¿±¿57.8¿¿g/kg) and spiramycin (1539.8¿±¿469.4¿¿g/kg), widely exceeding their legal maximum residue limits (MRLs) established, were detected in milk collected 24¿h after treatment, making the cheese production in most cases impossible. After the seven-day period, only spiramycin was detected in goat¿s milk (79.6¿±¿19.2¿¿g/kg) although no antibiotic residues were found in the cheeses. A withdrawal time of seven days seems suitable to guarantee milk safety after the administration of erythromycin and tylosin without any negative effects neither on the milk nor on the and cheese properties. However, given the rapid elimination of these substances, a shorter withdrawal period might be considered. For spiramycin, persisting in milk for a longer period, further studies on its pharmacokinetics in dairy goats would be recommendable to avoid a potential risk to consumer health.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/121373
url https://riunet.upv.es/handle/10251/121373
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2013-45147-R TRAZABILIDAD DE LA PRESENCIA DE ANTIBIOTICOS EN LECHE, QUESO Y LACTOSUERO DE CABRA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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