ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients

This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Detalles Bibliográficos
Autores: Vargas, Teodoro, Mendiola, Marta, Risueño, A., De Las Rivas, Javier, Maurel, Joan, Ramírez de Molina, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/134820
Acceso en línea:http://hdl.handle.net/10261/134820
Access Level:acceso abierto
Palabra clave:Colon cancer
Biomarkers
Prognosis
Lipid metabolism
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spelling ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patientsVargas, TeodoroMendiola, MartaRisueño, A.De Las Rivas, JavierMaurel, JoanRamírez de Molina, AnaColon cancerBiomarkersPrognosisLipid metabolismThis is an open-access article distributed under the terms of the Creative Commons Attribution License.This is a collaborative study between the Molecular Oncology Unit of The Institute of Advanced Studies of Madrid IMDEAFood and the Grupo Español Multidisciplinar en Cáncer Digestivo (GEMCAD).-- et al.Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolism-related genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to accurately stratify stage II colon cancer patients with 5-fold higher risk of relapse with strong statistical power in the four independent groups of patients. The identification of a group of 4 genes that predict survival in intermediate-stage colon cancer patients allows delineation of a high-risk group that may benefit from adjuvant therapy, and avoids the toxic and unnecessary chemotherapy in patients classified as low-risk group.This work was supported by Ministerio de Ciencia e Innovación del Gobierno de España (Plan Nacional I + D + i AGL2013–48943-C2–2-R and IPT-2011–1248-060000), Comunidad de Madrid (P2013/ABI-2728. ALIBIRDCM) and European Union Structural Funds. CIBEREHD is funded by the Instituto de Salud Carlos III.Peer ReviewedImpact JournalsInstituto de Salud Carlos IIIEuropean CommissionComunidad de MadridMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2016201620152016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/134820reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#S2013/ABI-2728/ALIBIRDhttp://dx.doi.org/10.18632/oncotarget.3130Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1348202026-05-22T06:33:51Z
dc.title.none.fl_str_mv ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
title ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
spellingShingle ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
Vargas, Teodoro
Colon cancer
Biomarkers
Prognosis
Lipid metabolism
title_short ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
title_full ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
title_fullStr ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
title_full_unstemmed ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
title_sort ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
dc.creator.none.fl_str_mv Vargas, Teodoro
Mendiola, Marta
Risueño, A.
De Las Rivas, Javier
Maurel, Joan
Ramírez de Molina, Ana
author Vargas, Teodoro
author_facet Vargas, Teodoro
Mendiola, Marta
Risueño, A.
De Las Rivas, Javier
Maurel, Joan
Ramírez de Molina, Ana
author_role author
author2 Mendiola, Marta
Risueño, A.
De Las Rivas, Javier
Maurel, Joan
Ramírez de Molina, Ana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Comunidad de Madrid
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Colon cancer
Biomarkers
Prognosis
Lipid metabolism
topic Colon cancer
Biomarkers
Prognosis
Lipid metabolism
description This is an open-access article distributed under the terms of the Creative Commons Attribution License.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/134820
url http://hdl.handle.net/10261/134820
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
S2013/ABI-2728/ALIBIRD
http://dx.doi.org/10.18632/oncotarget.3130
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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