Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis

Several environmental pollutants have been shown to damage brain and affect gut microbiota. Limited evidence is available about the impact of “chemical cocktails” (CC) of xenobiotics on brain metabolome and their possible influence in the gut-brain crosstalk. To this end, BALB/c mice were exposed to...

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Detalhes bibliográficos
Autores: Parra Martínez, Cecilio, Selma Royo, Marta, Callejón Leblic, María Belén, Collado, Maria Carmen, Abril, Nieves, García Barrera, Tamara
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad de Huelva (UHU)
Repositorio:Arias Montano. Repositorio Institucional de la Universidad de Huelva
Idioma:inglés
OAI Identifier:oai:ariasmontano.uhu.es:10272/21362
Acesso em linha:https://hdl.handle.net/10272/21362
Access Level:acceso abierto
Palavra-chave:Brain metabolomics
Selenium
Chemical cocktails
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spelling Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axisParra Martínez, CecilioSelma Royo, MartaCallejón Leblic, María BelénCollado, Maria CarmenAbril, NievesGarcía Barrera, TamaraBrain metabolomicsSeleniumChemical cocktailsSeveral environmental pollutants have been shown to damage brain and affect gut microbiota. Limited evidence is available about the impact of “chemical cocktails” (CC) of xenobiotics on brain metabolome and their possible influence in the gut-brain crosstalk. To this end, BALB/c mice were exposed to heavy metals (As, Hg, Cd) and pharmaceuticals (diclofenac and flumequine) under regular rodent diet or supplemented with selenium (Se). Selenium, an antioxidant well-known for its antagonism against the neurotoxicity of several pollutants, modulated several brain metabolic impairments caused by CC (e.g., brain levels of the excitatory amino acid N-acetyl aspartic acid) by influencing mainly the metabolisms of purine, glycosylate and dicarboxylate, glutamate, glycerophospholipid, alanine and aspartate. Numerous associations were obtained between brain metabolites and gut microbes and they changed after Se-supplementation (e.g., Lactobacillus was positively associated with a brain ceramide, phosphoserine, phosphocholine, vitamin D3 derivative, fatty acids, malic acid, amino acids, and urea after the exposure, but not after Se-supplementation). Our results showed numerous evidences about the impact of CC on brain metabolome, the potential role of Se as an antagonist and their impact on the gut-brain axis. Further research is needed to understand the complex mechanism of action implied on CC-brain-microbiota interactions.Elsevier20222022-09-1520222022-09-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10272/21362reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelvainstname:Universidad de Huelva (UHU)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ariasmontano.uhu.es:10272/213622026-06-02T14:58:11Z
dc.title.none.fl_str_mv Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
title Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
spellingShingle Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
Parra Martínez, Cecilio
Brain metabolomics
Selenium
Chemical cocktails
title_short Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
title_full Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
title_fullStr Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
title_full_unstemmed Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
title_sort Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis
dc.creator.none.fl_str_mv Parra Martínez, Cecilio
Selma Royo, Marta
Callejón Leblic, María Belén
Collado, Maria Carmen
Abril, Nieves
García Barrera, Tamara
author Parra Martínez, Cecilio
author_facet Parra Martínez, Cecilio
Selma Royo, Marta
Callejón Leblic, María Belén
Collado, Maria Carmen
Abril, Nieves
García Barrera, Tamara
author_role author
author2 Selma Royo, Marta
Callejón Leblic, María Belén
Collado, Maria Carmen
Abril, Nieves
García Barrera, Tamara
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Brain metabolomics
Selenium
Chemical cocktails
topic Brain metabolomics
Selenium
Chemical cocktails
description Several environmental pollutants have been shown to damage brain and affect gut microbiota. Limited evidence is available about the impact of “chemical cocktails” (CC) of xenobiotics on brain metabolome and their possible influence in the gut-brain crosstalk. To this end, BALB/c mice were exposed to heavy metals (As, Hg, Cd) and pharmaceuticals (diclofenac and flumequine) under regular rodent diet or supplemented with selenium (Se). Selenium, an antioxidant well-known for its antagonism against the neurotoxicity of several pollutants, modulated several brain metabolic impairments caused by CC (e.g., brain levels of the excitatory amino acid N-acetyl aspartic acid) by influencing mainly the metabolisms of purine, glycosylate and dicarboxylate, glutamate, glycerophospholipid, alanine and aspartate. Numerous associations were obtained between brain metabolites and gut microbes and they changed after Se-supplementation (e.g., Lactobacillus was positively associated with a brain ceramide, phosphoserine, phosphocholine, vitamin D3 derivative, fatty acids, malic acid, amino acids, and urea after the exposure, but not after Se-supplementation). Our results showed numerous evidences about the impact of CC on brain metabolome, the potential role of Se as an antagonist and their impact on the gut-brain axis. Further research is needed to understand the complex mechanism of action implied on CC-brain-microbiota interactions.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-09-15
2022
2022-09-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10272/21362
url https://hdl.handle.net/10272/21362
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname:Universidad de Huelva (UHU)
instname_str Universidad de Huelva (UHU)
reponame_str Arias Montano. Repositorio Institucional de la Universidad de Huelva
collection Arias Montano. Repositorio Institucional de la Universidad de Huelva
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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