Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014

ABSTRACT. Dengue is the most common mosquito-borne viral disease in humans. Although many dengue virus (DENV) infections are asymptomatic or produce only mild illness, DENV can occasionally cause severe and fatal disease. In this study, we compared the severity of primary and secondary DENV-1 infect...

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Authors: Camprubí Ferrer, Daniel, Torres Velásquez, Brenda, Pérez Padilla, Janice, Wong, Joshua, Sánchez González, Liliana, Munoz Jordan, Jorge L., Rodriguez Vargas, Dania M., Rivera Amill, Vanesa, Adams, Laura E., Paz Bailey, Gabriela
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::cb9f286c91ec10dbb3999095d3e053ca
Online Access:https://hdl.handle.net/2445/228838
Access Level:Embargoed access
Keyword:Dengue
Malalties víriques
Virus diseases
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spelling Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014Camprubí Ferrer, DanielTorres Velásquez, BrendaPérez Padilla, JaniceWong, JoshuaSánchez González, LilianaMunoz Jordan, Jorge L.Rodriguez Vargas, Dania M.Rivera Amill, VanesaAdams, Laura E.Paz Bailey, GabrielaDengueMalalties víriquesDengueVirus diseasesABSTRACT. Dengue is the most common mosquito-borne viral disease in humans. Although many dengue virus (DENV) infections are asymptomatic or produce only mild illness, DENV can occasionally cause severe and fatal disease. In this study, we compared the severity of primary and secondary DENV-1 infections among patients enrolled in a prospective, hospital-based, acute febrile illnesses surveillance system in Puerto Rico (2012–2014). Serum samples collected <7 days after symptom onset were tested for DENV-serotypes by a real time-polymerase chain reaction assay. The positive samples that were collected ≤5 days after onset were then tested by a DENV IgG antibody ELISA to classify primary (IgG negative) and secondary (IgG positive) infections. Overall, 720 dengue infections (679 DENV-1, 3 DENV-2, and 38 DENV-4) were diagnosed during the study period. Of the 679 DENV-1 patients, 595 were included in the study, 445 (75%) were classified as secondary infections, and 150 (25%) as primary infections. Among these patients, 150 (25%) were classified as severe dengue. Severe dengue occurred in 28% of secondary DENV-1 infections. Severe disease was also common among primary DENV-1 infections, including 27% with plasma leakage, 15% with severe dengue, and 9% requiring admission to the intensive care unit. Even though DENV-1 has caused thousands of cases in Puerto Rico, this is the first report describing DENV-1 as the cause of severe primary infection in this country. Although secondary DENV-1 infections have an increased risk for severe disease, it is important for clinicians to be aware that any individual with dengue should be considered at risk for severe dengue.American Society of Tropical Medicine and Hygiene2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/228838Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.4269/ajtmh.24-0508American Journal of Tropical Medicine and Hygiene, 2025, vol. 113, num. 2, p. 361-365https://doi.org/10.4269/ajtmh.24-0508(c) American Society of Tropical Medicine and Hygiene, 2025info:eu-repo/semantics/embargoedAccessoai:dnet:ubarcelona__::cb9f286c91ec10dbb3999095d3e053ca2026-05-27T06:46:51Z
dc.title.none.fl_str_mv Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
title Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
spellingShingle Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
Camprubí Ferrer, Daniel
Dengue
Malalties víriques
Dengue
Virus diseases
title_short Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
title_full Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
title_fullStr Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
title_full_unstemmed Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
title_sort Severity of Primary and Secondary Dengue Virus 1 Infections: A Hospital-Based Study in Puerto Rico, 2012–2014
dc.creator.none.fl_str_mv Camprubí Ferrer, Daniel
Torres Velásquez, Brenda
Pérez Padilla, Janice
Wong, Joshua
Sánchez González, Liliana
Munoz Jordan, Jorge L.
Rodriguez Vargas, Dania M.
Rivera Amill, Vanesa
Adams, Laura E.
Paz Bailey, Gabriela
author Camprubí Ferrer, Daniel
author_facet Camprubí Ferrer, Daniel
Torres Velásquez, Brenda
Pérez Padilla, Janice
Wong, Joshua
Sánchez González, Liliana
Munoz Jordan, Jorge L.
Rodriguez Vargas, Dania M.
Rivera Amill, Vanesa
Adams, Laura E.
Paz Bailey, Gabriela
author_role author
author2 Torres Velásquez, Brenda
Pérez Padilla, Janice
Wong, Joshua
Sánchez González, Liliana
Munoz Jordan, Jorge L.
Rodriguez Vargas, Dania M.
Rivera Amill, Vanesa
Adams, Laura E.
Paz Bailey, Gabriela
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dengue
Malalties víriques
Dengue
Virus diseases
topic Dengue
Malalties víriques
Dengue
Virus diseases
description ABSTRACT. Dengue is the most common mosquito-borne viral disease in humans. Although many dengue virus (DENV) infections are asymptomatic or produce only mild illness, DENV can occasionally cause severe and fatal disease. In this study, we compared the severity of primary and secondary DENV-1 infections among patients enrolled in a prospective, hospital-based, acute febrile illnesses surveillance system in Puerto Rico (2012–2014). Serum samples collected <7 days after symptom onset were tested for DENV-serotypes by a real time-polymerase chain reaction assay. The positive samples that were collected ≤5 days after onset were then tested by a DENV IgG antibody ELISA to classify primary (IgG negative) and secondary (IgG positive) infections. Overall, 720 dengue infections (679 DENV-1, 3 DENV-2, and 38 DENV-4) were diagnosed during the study period. Of the 679 DENV-1 patients, 595 were included in the study, 445 (75%) were classified as secondary infections, and 150 (25%) as primary infections. Among these patients, 150 (25%) were classified as severe dengue. Severe dengue occurred in 28% of secondary DENV-1 infections. Severe disease was also common among primary DENV-1 infections, including 27% with plasma leakage, 15% with severe dengue, and 9% requiring admission to the intensive care unit. Even though DENV-1 has caused thousands of cases in Puerto Rico, this is the first report describing DENV-1 as the cause of severe primary infection in this country. Although secondary DENV-1 infections have an increased risk for severe disease, it is important for clinicians to be aware that any individual with dengue should be considered at risk for severe dengue.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228838
url https://hdl.handle.net/2445/228838
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.4269/ajtmh.24-0508
American Journal of Tropical Medicine and Hygiene, 2025, vol. 113, num. 2, p. 361-365
https://doi.org/10.4269/ajtmh.24-0508
dc.rights.none.fl_str_mv (c) American Society of Tropical Medicine and Hygiene, 2025
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv (c) American Society of Tropical Medicine and Hygiene, 2025
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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