ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides

Herbicides inhibiting either aromatic or branched-chain amino acid biosynthesis trigger similar physiological responses in plants, despite their different mechanism of action. Both types of herbicides are known to activate ethanol fermentation by inducing the expression of fermentative genes; howeve...

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Autores: Gil Monreal, Miriam, Giuntoli, Beatrice, Zabalza Aznárez, Ana, Licausi, Francesco, Royuela Hernando, Mercedes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/36852
Acceso en línea:https://hdl.handle.net/2454/36852
Access Level:acceso abierto
Palabra clave:Amino acid biosynthesis-inhibiting herbicides
ERF-VII transcription factors
Ethanol fermentation
Glyphosate
Imazamox
N-degron pathway
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spelling ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicidesGil Monreal, MiriamGiuntoli, BeatriceZabalza Aznárez, AnaLicausi, FrancescoRoyuela Hernando, MercedesAmino acid biosynthesis-inhibiting herbicidesERF-VII transcription factorsEthanol fermentationGlyphosateImazamoxN-degron pathwayHerbicides inhibiting either aromatic or branched-chain amino acid biosynthesis trigger similar physiological responses in plants, despite their different mechanism of action. Both types of herbicides are known to activate ethanol fermentation by inducing the expression of fermentative genes; however, the mechanism of such transcriptional regulation has not been investigated so far. In plants exposed to low-oxygen conditions, ethanol fermentation is transcriptionally controlled by the ethylene response factors-VII (ERF-VIIs), whose stability is controlled in an oxygen-dependent manner by the Cys-Arg branch of the N-degron pathway. In this study, we investigated the role of ERF-VIIs in the regulation of the ethanol fermentation pathway in herbicide-treated Arabidopsis plants grown under aerobic conditions. Our results demonstrate that these transcriptional regulators are stabilized in response to herbicide treatment and are required for ethanol fermentation in these conditions. We also observed that mutants with reduced fermentative potential exhibit higher sensitivity to herbicide treatments, thus revealing the existence of a mechanism that mimics oxygen deprivation to activate metabolic pathways that enhance herbicide tolerance. We speculate that this signaling pathway may represent a potential target in agriculture to affect tolerance to herbicides that inhibit amino acid biosynthesis.MGM received funding from fellowships through Universidad Pública de Navarra. This work was financially supported by a grant from the Ministerio Español de Economía y Competitividad (AGL-2016-77531R).Oxford University PressInstitute for Multidisciplinary Research in Applied Biology - IMABUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/36852reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/ES/1PE/AGL2016-77531-R© The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comhttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/368522026-06-17T12:41:47Z
dc.title.none.fl_str_mv ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
title ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
spellingShingle ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
Gil Monreal, Miriam
Amino acid biosynthesis-inhibiting herbicides
ERF-VII transcription factors
Ethanol fermentation
Glyphosate
Imazamox
N-degron pathway
title_short ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
title_full ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
title_fullStr ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
title_full_unstemmed ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
title_sort ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides
dc.creator.none.fl_str_mv Gil Monreal, Miriam
Giuntoli, Beatrice
Zabalza Aznárez, Ana
Licausi, Francesco
Royuela Hernando, Mercedes
author Gil Monreal, Miriam
author_facet Gil Monreal, Miriam
Giuntoli, Beatrice
Zabalza Aznárez, Ana
Licausi, Francesco
Royuela Hernando, Mercedes
author_role author
author2 Giuntoli, Beatrice
Zabalza Aznárez, Ana
Licausi, Francesco
Royuela Hernando, Mercedes
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institute for Multidisciplinary Research in Applied Biology - IMAB
Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.subject.none.fl_str_mv Amino acid biosynthesis-inhibiting herbicides
ERF-VII transcription factors
Ethanol fermentation
Glyphosate
Imazamox
N-degron pathway
topic Amino acid biosynthesis-inhibiting herbicides
ERF-VII transcription factors
Ethanol fermentation
Glyphosate
Imazamox
N-degron pathway
description Herbicides inhibiting either aromatic or branched-chain amino acid biosynthesis trigger similar physiological responses in plants, despite their different mechanism of action. Both types of herbicides are known to activate ethanol fermentation by inducing the expression of fermentative genes; however, the mechanism of such transcriptional regulation has not been investigated so far. In plants exposed to low-oxygen conditions, ethanol fermentation is transcriptionally controlled by the ethylene response factors-VII (ERF-VIIs), whose stability is controlled in an oxygen-dependent manner by the Cys-Arg branch of the N-degron pathway. In this study, we investigated the role of ERF-VIIs in the regulation of the ethanol fermentation pathway in herbicide-treated Arabidopsis plants grown under aerobic conditions. Our results demonstrate that these transcriptional regulators are stabilized in response to herbicide treatment and are required for ethanol fermentation in these conditions. We also observed that mutants with reduced fermentative potential exhibit higher sensitivity to herbicide treatments, thus revealing the existence of a mechanism that mimics oxygen deprivation to activate metabolic pathways that enhance herbicide tolerance. We speculate that this signaling pathway may represent a potential target in agriculture to affect tolerance to herbicides that inhibit amino acid biosynthesis.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/36852
url https://hdl.handle.net/2454/36852
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/1PE/AGL2016-77531-R
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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