Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

Aging is a complex process. It is considered a risk factor for several diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which have an oxidative and inflammatory base. Given that life expectancy is increasing, there is a present interest in the searc...

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Authors: Martínez de Pablos, Rocío, Espinosa Oliva, Ana María, Hornedo Ortega, Ruth, Cano Rodríguez, María Mercedes, Argüelles Castilla, Sandro
Format: article
Status:Versión aceptada para publicación
Publication Date:2019
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/168028
Online Access:https://hdl.handle.net/11441/168028
https://doi.org/10.1016/j.phrs.2019.03.005
Access Level:Open access
Keyword:Aging
AMPK
Autophagy
Hydroxytyrosol
Mediterranean diet
Senescence
Sirtuin
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseasesMartínez de Pablos, RocíoEspinosa Oliva, Ana MaríaHornedo Ortega, RuthCano Rodríguez, María MercedesArgüelles Castilla, SandroAgingAMPKAutophagyHydroxytyrosolMediterranean dietSenescenceSirtuinAging is a complex process. It is considered a risk factor for several diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which have an oxidative and inflammatory base. Given that life expectancy is increasing, there is a present interest in the search for anti-aging strategies that allow a healthy aging. Interestingly, in Spain, where the Mediterranean Diet (MD) is the reference food pattern, life expectancy will have the highest average by 2040. This diet is characterized, among other items, by virgin olive oil intake, which contains between 50–200 mg/kg of hydroxytyrosol, a major polyphenolic component of olive oil. Hydroxytyrosol is formed by the hydrolysis of oleuropein during the maturing of olives, storage of olive oil, and preparation of table olives. It is a yield of oleuropein by microbiota action in the organism after virgin olive oil consumption. The daily intake in context of the MD is estimated to be around 0.15 and 30 mg/day. In the last few years, hydroxytyrosol has received increasing attention due to its multiple pharmacological activities, such as antioxidant, anti-inflammatory and pro-apoptotic activities. It has also been the focus of extensive research regarding its bioactivity. In this sense, hydroxytyrosol is under consideration for the development of new anti-aging strategies. In this review we will summarize the potential anti-aging effects of hydroxytyrosol and its protective role in several age-related diseases.ElsevierBioquímica y Biología MolecularFisiologíaMinisterio de Economía y Competitividad (MINECO). EspañaEuropean Union (UE)2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/168028https://doi.org/10.1016/j.phrs.2019.03.005reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésSAF2015-64171-Rhttps://doi.org/10.1016/j.phrs.2019.03.005info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1680282026-06-17T12:51:07Z
dc.title.none.fl_str_mv Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
title Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
spellingShingle Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
Martínez de Pablos, Rocío
Aging
AMPK
Autophagy
Hydroxytyrosol
Mediterranean diet
Senescence
Sirtuin
title_short Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
title_full Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
title_fullStr Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
title_full_unstemmed Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
title_sort Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases
dc.creator.none.fl_str_mv Martínez de Pablos, Rocío
Espinosa Oliva, Ana María
Hornedo Ortega, Ruth
Cano Rodríguez, María Mercedes
Argüelles Castilla, Sandro
author Martínez de Pablos, Rocío
author_facet Martínez de Pablos, Rocío
Espinosa Oliva, Ana María
Hornedo Ortega, Ruth
Cano Rodríguez, María Mercedes
Argüelles Castilla, Sandro
author_role author
author2 Espinosa Oliva, Ana María
Hornedo Ortega, Ruth
Cano Rodríguez, María Mercedes
Argüelles Castilla, Sandro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Bioquímica y Biología Molecular
Fisiología
Ministerio de Economía y Competitividad (MINECO). España
European Union (UE)
dc.subject.none.fl_str_mv Aging
AMPK
Autophagy
Hydroxytyrosol
Mediterranean diet
Senescence
Sirtuin
topic Aging
AMPK
Autophagy
Hydroxytyrosol
Mediterranean diet
Senescence
Sirtuin
description Aging is a complex process. It is considered a risk factor for several diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which have an oxidative and inflammatory base. Given that life expectancy is increasing, there is a present interest in the search for anti-aging strategies that allow a healthy aging. Interestingly, in Spain, where the Mediterranean Diet (MD) is the reference food pattern, life expectancy will have the highest average by 2040. This diet is characterized, among other items, by virgin olive oil intake, which contains between 50–200 mg/kg of hydroxytyrosol, a major polyphenolic component of olive oil. Hydroxytyrosol is formed by the hydrolysis of oleuropein during the maturing of olives, storage of olive oil, and preparation of table olives. It is a yield of oleuropein by microbiota action in the organism after virgin olive oil consumption. The daily intake in context of the MD is estimated to be around 0.15 and 30 mg/day. In the last few years, hydroxytyrosol has received increasing attention due to its multiple pharmacological activities, such as antioxidant, anti-inflammatory and pro-apoptotic activities. It has also been the focus of extensive research regarding its bioactivity. In this sense, hydroxytyrosol is under consideration for the development of new anti-aging strategies. In this review we will summarize the potential anti-aging effects of hydroxytyrosol and its protective role in several age-related diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/168028
https://doi.org/10.1016/j.phrs.2019.03.005
url https://hdl.handle.net/11441/168028
https://doi.org/10.1016/j.phrs.2019.03.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SAF2015-64171-R
https://doi.org/10.1016/j.phrs.2019.03.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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