Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron

A feasibility study of an experimental setup for the irradiation of biological samples at the cyclotron facility installed at the National Centre of Accelerators (Seville, Spain) is presented. This cyclotron, which counts on an external beam line for interdisciplinary research purposes, produces an...

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Autores: Baratto-Roldan, Anna, Jiménez-Ramos, M. C., Battaglia, M. C., García López, J., Gallardo, María Isabel, Cortés-Giraldo, Miguel Antonio, Espino, J. M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/194931
Acceso en línea:http://hdl.handle.net/10261/194931
Access Level:acceso abierto
Palabra clave:Proton beams
Beam characterization
Radiochromic films
Radiobiology
Dosimetry
IBA cyclotron
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spelling Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV CyclotronBaratto-Roldan, AnnaJiménez-Ramos, M. C.Battaglia, M. C.García López, J.Gallardo, María IsabelCortés-Giraldo, Miguel AntonioEspino, J. M.Proton beamsBeam characterizationRadiochromic filmsRadiobiologyDosimetryIBA cyclotronA feasibility study of an experimental setup for the irradiation of biological samples at the cyclotron facility installed at the National Centre of Accelerators (Seville, Spain) is presented. This cyclotron, which counts on an external beam line for interdisciplinary research purposes, produces an 18 MeV proton beam, which is suitable for the irradiation of mono-layer cultures for the measurement of proton cell damages and Relative Biological Effectiveness (RBE) at energies below the beam nominal value. Measurements of this kind are of interest for proton therapy, since the variation of proton RBE at the distal edge of the Bragg curve may have implications in clinical proton therapy treatments. In the following, the characteristics of the beam line and the solutions implemented for the irradiation of biological samples are described. When dealing with the irradiation of cell cultures, low beam intensities and broad homogeneous irradiation fields are required, in order to assure that all the cells receive the same dose with a suitable dose rate. At the cyclotron, these constraints have been achieved by completely defocusing the beam, intercepting the beam path with tungsten scattering foils and varying the exit-window-to-sample distance. The properties of the proton beam thus obtained have been analysed and compared with Monte Carlo simulations. The results of this comparison, as well as the experimental measurement of the lateral dose profiles expected at the position of samples are presented. Meaningful dose rates of about 2–3 Gy/min have been obtained. Homogeneous lateral dose profiles, with maximum deviations of 5%, have been measured at a distance of approximately 50 cm in air from the exit window, placing a tungsten scattering foil of 200 µm in the beam path.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant No. 675265, OMA—Optimization of Medical Accelerators, from the Spanish Ministry of Economy and Competitiveness under Grant No. FPA2016-77689-C2-1-R, and from the Council for Innovation, Science and Commerce of the Andalusian Government under Grant No. P12-FQM-1605.Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionMinisterio de Economía y Competitividad (España)Junta de AndalucíaJiménez-Ramos, M. C. [0000-0001-7109-1040]García López, J. [0000-0003-4107-4383]Gallardo, M. I. [0000-0002-8671-5589]Espino, J. M. [0000-0003-4848-5847]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/194931reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/675265info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FPA2016-77689-C2-1-Rhttp://dx.doi.org/10.3390/instruments2040026Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1949312026-05-22T06:33:51Z
dc.title.none.fl_str_mv Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
title Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
spellingShingle Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
Baratto-Roldan, Anna
Proton beams
Beam characterization
Radiochromic films
Radiobiology
Dosimetry
IBA cyclotron
title_short Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
title_full Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
title_fullStr Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
title_full_unstemmed Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
title_sort Feasibility study of a proton irradiation facility for fadiobiological measurements at an 18 MeV Cyclotron
dc.creator.none.fl_str_mv Baratto-Roldan, Anna
Jiménez-Ramos, M. C.
Battaglia, M. C.
García López, J.
Gallardo, María Isabel
Cortés-Giraldo, Miguel Antonio
Espino, J. M.
author Baratto-Roldan, Anna
author_facet Baratto-Roldan, Anna
Jiménez-Ramos, M. C.
Battaglia, M. C.
García López, J.
Gallardo, María Isabel
Cortés-Giraldo, Miguel Antonio
Espino, J. M.
author_role author
author2 Jiménez-Ramos, M. C.
Battaglia, M. C.
García López, J.
Gallardo, María Isabel
Cortés-Giraldo, Miguel Antonio
Espino, J. M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Economía y Competitividad (España)
Junta de Andalucía
Jiménez-Ramos, M. C. [0000-0001-7109-1040]
García López, J. [0000-0003-4107-4383]
Gallardo, M. I. [0000-0002-8671-5589]
Espino, J. M. [0000-0003-4848-5847]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Proton beams
Beam characterization
Radiochromic films
Radiobiology
Dosimetry
IBA cyclotron
topic Proton beams
Beam characterization
Radiochromic films
Radiobiology
Dosimetry
IBA cyclotron
description A feasibility study of an experimental setup for the irradiation of biological samples at the cyclotron facility installed at the National Centre of Accelerators (Seville, Spain) is presented. This cyclotron, which counts on an external beam line for interdisciplinary research purposes, produces an 18 MeV proton beam, which is suitable for the irradiation of mono-layer cultures for the measurement of proton cell damages and Relative Biological Effectiveness (RBE) at energies below the beam nominal value. Measurements of this kind are of interest for proton therapy, since the variation of proton RBE at the distal edge of the Bragg curve may have implications in clinical proton therapy treatments. In the following, the characteristics of the beam line and the solutions implemented for the irradiation of biological samples are described. When dealing with the irradiation of cell cultures, low beam intensities and broad homogeneous irradiation fields are required, in order to assure that all the cells receive the same dose with a suitable dose rate. At the cyclotron, these constraints have been achieved by completely defocusing the beam, intercepting the beam path with tungsten scattering foils and varying the exit-window-to-sample distance. The properties of the proton beam thus obtained have been analysed and compared with Monte Carlo simulations. The results of this comparison, as well as the experimental measurement of the lateral dose profiles expected at the position of samples are presented. Meaningful dose rates of about 2–3 Gy/min have been obtained. Homogeneous lateral dose profiles, with maximum deviations of 5%, have been measured at a distance of approximately 50 cm in air from the exit window, placing a tungsten scattering foil of 200 µm in the beam path.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/194931
url http://hdl.handle.net/10261/194931
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/675265
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FPA2016-77689-C2-1-R
http://dx.doi.org/10.3390/instruments2040026
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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