Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency

Aquest mateix article està publicat a l'edició alemanya d''Angewandte Chemie' (ISSN 0044-8249, EISSN 1521-3757), 2004, vol.131, núm. 10, Special Issue: Frauen in der Chemie, p. 3129-3133. DOI https://doi.org/10.1002/ange.201812532

Detalles Bibliográficos
Autores: Curado-Carballada, Christian, Feixas Geronès, Ferran, Iglesias-Fernández, Javier, Osuna Oliveras, Sílvia
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/16387
Acceso en línea:http://hdl.handle.net/10256/16387
Access Level:acceso abierto
Palabra clave:Catàlisi homogènia
Homogeneous catalysis
Dinàmica molecular
Molecular dynamics
Enzims
Enzymes
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spelling Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic EfficiencyCurado-Carballada, ChristianFeixas Geronès, FerranIglesias-Fernández, JavierOsuna Oliveras, SílviaCatàlisi homogèniaHomogeneous catalysisDinàmica molecularMolecular dynamicsEnzimsEnzymesAquest mateix article està publicat a l'edició alemanya d''Angewandte Chemie' (ISSN 0044-8249, EISSN 1521-3757), 2004, vol.131, núm. 10, Special Issue: Frauen in der Chemie, p. 3129-3133. DOI https://doi.org/10.1002/ange.201812532Enzymes exist as an ensemble of conformational states, whose populations can be shifted by substrate binding, allosteric interactions, but also by introducing mutations to their sequence. Tuning the populations of the enzyme conformational states through mutation enables evolution towards novel activity. Herein, Markov state models are used to unveil hidden conformational states of monoamine oxidase from Aspergillus niger (MAO-N). These hidden conformations, not previously observed by any other technique, play a crucial role in substrate binding and enzyme activity. This reveals how distal mutations regulate MAO-N activity by stabilizing these hidden, catalytically important conformational states, but also by modulating the communication pathway between both MAO-N subunitsWileyinfo2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/16387http://hdl.handle.net/10256/16387© Angewandte Chemie International Edition, 2019, vol. 58, núm. 10, p. 3097-3101Articles publicats (D-Q)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1002/anie.201812532info:eu-repo/semantics/altIdentifier/issn/1433-7851info:eu-repo/semantics/altIdentifier/eissn/1521-3773Tots els drets reservatsinfo:eu-repo/semantics/openAccessoai:recercat.cat:10256/163872026-05-29T05:05:01Z
dc.title.none.fl_str_mv Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
title Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
spellingShingle Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
Curado-Carballada, Christian
Catàlisi homogènia
Homogeneous catalysis
Dinàmica molecular
Molecular dynamics
Enzims
Enzymes
title_short Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
title_full Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
title_fullStr Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
title_full_unstemmed Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
title_sort Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
dc.creator.none.fl_str_mv Curado-Carballada, Christian
Feixas Geronès, Ferran
Iglesias-Fernández, Javier
Osuna Oliveras, Sílvia
author Curado-Carballada, Christian
author_facet Curado-Carballada, Christian
Feixas Geronès, Ferran
Iglesias-Fernández, Javier
Osuna Oliveras, Sílvia
author_role author
author2 Feixas Geronès, Ferran
Iglesias-Fernández, Javier
Osuna Oliveras, Sílvia
author2_role author
author
author
dc.subject.none.fl_str_mv Catàlisi homogènia
Homogeneous catalysis
Dinàmica molecular
Molecular dynamics
Enzims
Enzymes
topic Catàlisi homogènia
Homogeneous catalysis
Dinàmica molecular
Molecular dynamics
Enzims
Enzymes
description Aquest mateix article està publicat a l'edició alemanya d''Angewandte Chemie' (ISSN 0044-8249, EISSN 1521-3757), 2004, vol.131, núm. 10, Special Issue: Frauen in der Chemie, p. 3129-3133. DOI https://doi.org/10.1002/ange.201812532
publishDate 2019
dc.date.none.fl_str_mv 2019
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
peer-reviewed
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/16387
http://hdl.handle.net/10256/16387
url http://hdl.handle.net/10256/16387
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/anie.201812532
info:eu-repo/semantics/altIdentifier/issn/1433-7851
info:eu-repo/semantics/altIdentifier/eissn/1521-3773
dc.rights.none.fl_str_mv Tots els drets reservats
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Tots els drets reservats
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv © Angewandte Chemie International Edition, 2019, vol. 58, núm. 10, p. 3097-3101
Articles publicats (D-Q)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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