Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances...

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Detalhes bibliográficos
Autores: Louro, Henriqueta, Heinälä, Milla, Bessems, Jos, Buekers, Jurgen, Vermeire, Theo, Woutersen, Marjolijn, van Engelen, Jacqueline, Borges, Teresa, Rousselle, Christophe, Ougier, Eva, Alvito, Paula, Martins, Carla, Assunção, Ricardo, Silva, Maria João, Pronk, Anjoeka, Schaddelee-Scholten, Bernice, De Alba-González, Mercedes, Castaño, Argelia, Gonzalez, Carlos, Viegas, Susana, Humar-Juric, Tatjana, Kononenko, Lijana, Lampen, Alfonso, Vinggaard, Anne Marie, Schoeters, Greet, Kolossa-Gehring, Marike, Santonen, Tiina
Tipo de documento: artigo
Data de publicação:2019
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositório:Repisalud
Idioma:inglês
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/11360
Acesso em linha:http://hdl.handle.net/20.500.12105/11360
Access Level:Acceso aberto
Palavra-chave:Biological Monitoring
Forecasting
Environmental Exposure
Environmental Pollutants
Europe
Humans
Risk Assessment
World Health Organization
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spelling Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the futureLouro, HenriquetaHeinälä, MillaBessems, JosBuekers, JurgenVermeire, TheoWoutersen, Marjolijnvan Engelen, JacquelineBorges, TeresaRousselle, ChristopheOugier, EvaAlvito, PaulaMartins, CarlaAssunção, RicardoSilva, Maria JoãoPronk, AnjoekaSchaddelee-Scholten, BerniceDe Alba-González, MercedesCastaño, ArgeliaGonzalez, CarlosViegas, SusanaHumar-Juric, TatjanaKononenko, LijanaLampen, AlfonsoVinggaard, Anne MarieSchoeters, GreetKolossa-Gehring, MarikeSantonen, TiinaBiological MonitoringForecastingEnvironmental ExposureEnvironmental PollutantsEuropeHumansRisk AssessmentWorld Health OrganizationHuman biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017-2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).ElsevierUnión Europea20202020-11-1720192019-01-0120192019-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/11360reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032 HBM4EUopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/113602026-06-12T12:43:37Z
dc.title.none.fl_str_mv Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
title Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
spellingShingle Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
Louro, Henriqueta
Biological Monitoring
Forecasting
Environmental Exposure
Environmental Pollutants
Europe
Humans
Risk Assessment
World Health Organization
title_short Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
title_full Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
title_fullStr Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
title_full_unstemmed Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
title_sort Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
dc.creator.none.fl_str_mv Louro, Henriqueta
Heinälä, Milla
Bessems, Jos
Buekers, Jurgen
Vermeire, Theo
Woutersen, Marjolijn
van Engelen, Jacqueline
Borges, Teresa
Rousselle, Christophe
Ougier, Eva
Alvito, Paula
Martins, Carla
Assunção, Ricardo
Silva, Maria João
Pronk, Anjoeka
Schaddelee-Scholten, Bernice
De Alba-González, Mercedes
Castaño, Argelia
Gonzalez, Carlos
Viegas, Susana
Humar-Juric, Tatjana
Kononenko, Lijana
Lampen, Alfonso
Vinggaard, Anne Marie
Schoeters, Greet
Kolossa-Gehring, Marike
Santonen, Tiina
author Louro, Henriqueta
author_facet Louro, Henriqueta
Heinälä, Milla
Bessems, Jos
Buekers, Jurgen
Vermeire, Theo
Woutersen, Marjolijn
van Engelen, Jacqueline
Borges, Teresa
Rousselle, Christophe
Ougier, Eva
Alvito, Paula
Martins, Carla
Assunção, Ricardo
Silva, Maria João
Pronk, Anjoeka
Schaddelee-Scholten, Bernice
De Alba-González, Mercedes
Castaño, Argelia
Gonzalez, Carlos
Viegas, Susana
Humar-Juric, Tatjana
Kononenko, Lijana
Lampen, Alfonso
Vinggaard, Anne Marie
Schoeters, Greet
Kolossa-Gehring, Marike
Santonen, Tiina
author_role author
author2 Heinälä, Milla
Bessems, Jos
Buekers, Jurgen
Vermeire, Theo
Woutersen, Marjolijn
van Engelen, Jacqueline
Borges, Teresa
Rousselle, Christophe
Ougier, Eva
Alvito, Paula
Martins, Carla
Assunção, Ricardo
Silva, Maria João
Pronk, Anjoeka
Schaddelee-Scholten, Bernice
De Alba-González, Mercedes
Castaño, Argelia
Gonzalez, Carlos
Viegas, Susana
Humar-Juric, Tatjana
Kononenko, Lijana
Lampen, Alfonso
Vinggaard, Anne Marie
Schoeters, Greet
Kolossa-Gehring, Marike
Santonen, Tiina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Unión Europea
dc.subject.none.fl_str_mv Biological Monitoring
Forecasting
Environmental Exposure
Environmental Pollutants
Europe
Humans
Risk Assessment
World Health Organization
topic Biological Monitoring
Forecasting
Environmental Exposure
Environmental Pollutants
Europe
Humans
Risk Assessment
World Health Organization
description Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017-2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
2020
2020-11-17
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/11360
url http://hdl.handle.net/20.500.12105/11360
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032 HBM4EU
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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