Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates

Osteonecrosis of the jaws (ONJ) is an important possible late adverse effect of bisphosphonates. Serum C-terminal cross-linking telopeptide of type I collagen (CTX) can determine bone turnover and can act as a biological marker of bone resorption. We studied this biological marker in 15 patients (Gr...

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Detalles Bibliográficos
Autores: Bagán, José Vicente, Jiménez, Yolanda, Gómez Adrián, María Dolores, Sirera, Rafael, Poveda, Rafael, Scully, Crispian
Tipo de recurso: artículo
Fecha de publicación:2008
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/4974
Acceso en línea:http://hdl.handle.net/20.500.12466/4974
Access Level:acceso abierto
Palabra clave:Bisphosphonates
Osteonecrosis
Jaws
3201.01 Oncología
3213.13 Ortodoncia-Estomatología
Descripción
Sumario:Osteonecrosis of the jaws (ONJ) is an important possible late adverse effect of bisphosphonates. Serum C-terminal cross-linking telopeptide of type I collagen (CTX) can determine bone turnover and can act as a biological marker of bone resorption. We studied this biological marker in 15 patients (Group 1) with bisphosphonate-induced ONJ comparing with a control group of 10 healthy people matched by age and gender. We found no statistically significant relationships in Group 1 either between the serum CTX and the number of areas of exposed bone nor with the size of the osteonecrotic area.

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