Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia

Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related to HTG and the risk of NAFLD has been scarcely studied. Methods: A total of 185 subjects with modera...

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Autores: Esteve Luque, Virginia, Padró i Miquel, Ariadna, Fanlo Maresma, Marta, Corbella, Emili, Corbella, Xavier, Pintó Sala, Xavier, Candás Estébanez, Beatriz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/175989
Acceso en línea:https://hdl.handle.net/2445/175989
Access Level:acceso abierto
Palabra clave:Trastorns del metabolisme
Malalties del fetge
Disorders of metabolism
Liver diseases
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spelling Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with HypertriglyceridemiaEsteve Luque, VirginiaPadró i Miquel, AriadnaFanlo Maresma, MartaCorbella, EmiliCorbella, XavierPintó Sala, XavierCandás Estébanez, BeatrizTrastorns del metabolismeMalalties del fetgeDisorders of metabolismLiver diseasesBackground: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related to HTG and the risk of NAFLD has been scarcely studied. Methods: A total of 185 subjects with moderate HTG were prospectively included. We investigated the association between genetic factors' (five allelic variants with polygenic hypertriglyceridemia) clinical and biochemical biomarkers with NAFLD severity. The five allelic variants' related clinical and biochemical data of HTG were studied in all the subjects. NAFLD was assessed by abdominal ultrasound and patients were divided into two groups, one with no or mild NAFLD and another with moderate/severe NAFLD. Results: Patients with moderate/severe NAFLD had higher weight and waist values and a higher prevalence of insulin resistance than patients with no or mild NAFLD. Moderate/severe NAFLD was independently associated with APOA5 rs3134406 and ZPR1 rs964184 variants, and also showed a significant inverse relationship with lipoprotein(a) [Lp(a)] concentrations. Conclusions: APOA5 rs3135506 and ZPR1 rs964184 variants and lipoprotein(a) are associated with moderate/severe NAFLD. This association was independent of body weight, insulin resistance, and other factors related to NAFLD.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/175989Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu13020552Nutrients, 2021, vol. 13, num. 2https://doi.org/10.3390/nu13020552cc by (c) Esteve Luque et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1759892026-05-27T06:46:51Z
dc.title.none.fl_str_mv Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
title Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
spellingShingle Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
Esteve Luque, Virginia
Trastorns del metabolisme
Malalties del fetge
Disorders of metabolism
Liver diseases
title_short Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
title_full Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
title_fullStr Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
title_full_unstemmed Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
title_sort Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia
dc.creator.none.fl_str_mv Esteve Luque, Virginia
Padró i Miquel, Ariadna
Fanlo Maresma, Marta
Corbella, Emili
Corbella, Xavier
Pintó Sala, Xavier
Candás Estébanez, Beatriz
author Esteve Luque, Virginia
author_facet Esteve Luque, Virginia
Padró i Miquel, Ariadna
Fanlo Maresma, Marta
Corbella, Emili
Corbella, Xavier
Pintó Sala, Xavier
Candás Estébanez, Beatriz
author_role author
author2 Padró i Miquel, Ariadna
Fanlo Maresma, Marta
Corbella, Emili
Corbella, Xavier
Pintó Sala, Xavier
Candás Estébanez, Beatriz
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorns del metabolisme
Malalties del fetge
Disorders of metabolism
Liver diseases
topic Trastorns del metabolisme
Malalties del fetge
Disorders of metabolism
Liver diseases
description Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related to HTG and the risk of NAFLD has been scarcely studied. Methods: A total of 185 subjects with moderate HTG were prospectively included. We investigated the association between genetic factors' (five allelic variants with polygenic hypertriglyceridemia) clinical and biochemical biomarkers with NAFLD severity. The five allelic variants' related clinical and biochemical data of HTG were studied in all the subjects. NAFLD was assessed by abdominal ultrasound and patients were divided into two groups, one with no or mild NAFLD and another with moderate/severe NAFLD. Results: Patients with moderate/severe NAFLD had higher weight and waist values and a higher prevalence of insulin resistance than patients with no or mild NAFLD. Moderate/severe NAFLD was independently associated with APOA5 rs3134406 and ZPR1 rs964184 variants, and also showed a significant inverse relationship with lipoprotein(a) [Lp(a)] concentrations. Conclusions: APOA5 rs3135506 and ZPR1 rs964184 variants and lipoprotein(a) are associated with moderate/severe NAFLD. This association was independent of body weight, insulin resistance, and other factors related to NAFLD.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/175989
url https://hdl.handle.net/2445/175989
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu13020552
Nutrients, 2021, vol. 13, num. 2
https://doi.org/10.3390/nu13020552
dc.rights.none.fl_str_mv cc by (c) Esteve Luque et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Esteve Luque et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
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