Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders

Addiction treatment is a long-term goal and therefore prefrontal–striatal regions regulating goal-directed behavior are to be associated with individual differences on treatment motivation. We aimed at examining the association between gray matter volumes in prefrontal cortices and striatum and read...

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Autores: Moreno López, Laura, Albein Urios, Natalia, Martinez Gonzalez, José Miguel, Soriano Mas, Carles, Verdejo García, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126344
Acceso en línea:https://hdl.handle.net/2445/126344
Access Level:acceso abierto
Palabra clave:Drogoaddicció
Trastorns de la personalitat
Drug addiction
Personality disorders
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spelling Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disordersMoreno López, LauraAlbein Urios, NataliaMartinez Gonzalez, José MiguelSoriano Mas, CarlesVerdejo García, AntonioDrogoaddiccióTrastorns de la personalitatDrug addictionPersonality disordersAddiction treatment is a long-term goal and therefore prefrontal–striatal regions regulating goal-directed behavior are to be associated with individual differences on treatment motivation. We aimed at examining the association between gray matter volumes in prefrontal cortices and striatum and readiness to change at treatment onset in cocaine users with and without personality disorders. Participants included 17 cocaine users without psychiatric comorbidities, 17 cocaine users with Cluster B disorders, and 12 cocaine users with Cluster C disorders. They completed the University of Rhode Island Change Assessment Scale, which measures four stages of treatment change (precontemplation, contemplation, action, and maintenance) and overall readiness to change, and were scanned in a 3T MRI scanner. We defined three regions of interest (ROIs): the ventromedial prefrontal cortex (including medial orbitofrontal cortex and subgenual and rostral anterior cingulate cortex), the dorsomedial prefrontal cortex (i.e., superior medial frontal cortex), and the neostriatum (caudate and putamen). We found that readiness to change correlated with different aspects of ventromedial prefrontal gray matter as a function of diagnosis. In cocaine users with Cluster C comorbidities, readiness to change positively correlated with gyrus rectus gray matter, whereas in cocaine users without comorbidities it negatively correlated with rostral anterior cingulate cortex gray matter. Moreover, maintenance scores positively correlated with dorsomedial prefrontal gray matter in cocaine users with Cluster C comorbidities, but negatively correlated with this region in cocaine users with Cluster B and cocaine users without comorbidities. Maintenance scores also negatively correlated with dorsal striatum gray matter in cocaine users with Cluster C comorbidities. We conclude that the link between prefrontal–striatal gray matter and treatment motivation is modulated by co-existence of personality disorders.Frontiers Media2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126344Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fpsyt.2014.00052Frontiers in Psychiatry, 2014, vol. 5https://doi.org/10.3389/fpsyt.2014.00052cc by (c) Moreno López et al., 2014http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1263442026-05-27T06:46:51Z
dc.title.none.fl_str_mv Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
title Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
spellingShingle Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
Moreno López, Laura
Drogoaddicció
Trastorns de la personalitat
Drug addiction
Personality disorders
title_short Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
title_full Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
title_fullStr Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
title_full_unstemmed Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
title_sort Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
dc.creator.none.fl_str_mv Moreno López, Laura
Albein Urios, Natalia
Martinez Gonzalez, José Miguel
Soriano Mas, Carles
Verdejo García, Antonio
author Moreno López, Laura
author_facet Moreno López, Laura
Albein Urios, Natalia
Martinez Gonzalez, José Miguel
Soriano Mas, Carles
Verdejo García, Antonio
author_role author
author2 Albein Urios, Natalia
Martinez Gonzalez, José Miguel
Soriano Mas, Carles
Verdejo García, Antonio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Drogoaddicció
Trastorns de la personalitat
Drug addiction
Personality disorders
topic Drogoaddicció
Trastorns de la personalitat
Drug addiction
Personality disorders
description Addiction treatment is a long-term goal and therefore prefrontal–striatal regions regulating goal-directed behavior are to be associated with individual differences on treatment motivation. We aimed at examining the association between gray matter volumes in prefrontal cortices and striatum and readiness to change at treatment onset in cocaine users with and without personality disorders. Participants included 17 cocaine users without psychiatric comorbidities, 17 cocaine users with Cluster B disorders, and 12 cocaine users with Cluster C disorders. They completed the University of Rhode Island Change Assessment Scale, which measures four stages of treatment change (precontemplation, contemplation, action, and maintenance) and overall readiness to change, and were scanned in a 3T MRI scanner. We defined three regions of interest (ROIs): the ventromedial prefrontal cortex (including medial orbitofrontal cortex and subgenual and rostral anterior cingulate cortex), the dorsomedial prefrontal cortex (i.e., superior medial frontal cortex), and the neostriatum (caudate and putamen). We found that readiness to change correlated with different aspects of ventromedial prefrontal gray matter as a function of diagnosis. In cocaine users with Cluster C comorbidities, readiness to change positively correlated with gyrus rectus gray matter, whereas in cocaine users without comorbidities it negatively correlated with rostral anterior cingulate cortex gray matter. Moreover, maintenance scores positively correlated with dorsomedial prefrontal gray matter in cocaine users with Cluster C comorbidities, but negatively correlated with this region in cocaine users with Cluster B and cocaine users without comorbidities. Maintenance scores also negatively correlated with dorsal striatum gray matter in cocaine users with Cluster C comorbidities. We conclude that the link between prefrontal–striatal gray matter and treatment motivation is modulated by co-existence of personality disorders.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126344
url https://hdl.handle.net/2445/126344
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fpsyt.2014.00052
Frontiers in Psychiatry, 2014, vol. 5
https://doi.org/10.3389/fpsyt.2014.00052
dc.rights.none.fl_str_mv cc by (c) Moreno López et al., 2014
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Moreno López et al., 2014
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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