Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze th...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/174252 |
| Acceso en línea: | https://hdl.handle.net/2445/174252 |
| Access Level: | acceso abierto |
| Palabra clave: | Càncer colorectal Contaminació atmosfèrica Zones industrials Colorectal cancer Atmospheric pollution Industrial sites |
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Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)García Pérez, JavierFernández de Larrea Baz, NereaLope, VirginiaMolina de la Torre, Antonio JoséO'Callaghan Gordo, CristinaAlonso Aguado, Maria HenarRodríguez Suárez, Marta MaríaMirón Pozo, BenitoAlguacil, JuanGómez Acebo, InésAscunce, NievesVanaclocha Espi, MercedesAmiano, PilarChirlaque, María DoloresSimó, VicenteJiménez Moleón, José JuanTardón, AdoninaMoreno Aguado, VíctorCastaño-Vinyals, GemmaMartín Sánchez, VicenteAragonès Sanz, NúriaPérez Gómez, BeatrizKogevinas, ManolisPollán, MarinaCàncer colorectalContaminació atmosfèricaZones industrialsColorectal cancerAtmospheric pollutionIndustrial sitesBackground: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects' residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44-2.87) to 3 km (1.26; 1.00-1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (<= 3 km) production of metals (2.66; 1.77-4.00), surface treatment of metals (1.48; 1.08-2.02), glass and mineral fibers (2.06; 1.39-3.07), organic chemical industry (4.80; 3.20-7.20), inorganic chemical industry (6.74; 4.38-10.36), food/beverage sector (3.34; 2.38-4.68), and surface treatment using organic solvents (6.16; 4.06-9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (<= 3 km) industries releasing nonylphenol (9.19; 5.91-14.28), antimony (5.30; 3.45-8.15), naphthalene (3.11; 2.16-4.49), organotin compounds (2.64; 1.76-3.98), manganese (2.53; 1.63-3.93), dichloromethane (2.52; 1.74-3.66), and vanadium (2.49; 1.59-3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.Elsevier2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174252Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.envint.2020.106055Environment International, 2020, vol. 144, p. 106055https://doi.org/10.1016/j.envint.2020.106055cc by-nc-nd (c) García Pérez et al., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1742522026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| title |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| spellingShingle |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) García Pérez, Javier Càncer colorectal Contaminació atmosfèrica Zones industrials Colorectal cancer Atmospheric pollution Industrial sites |
| title_short |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| title_full |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| title_fullStr |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| title_full_unstemmed |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| title_sort |
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain) |
| dc.creator.none.fl_str_mv |
García Pérez, Javier Fernández de Larrea Baz, Nerea Lope, Virginia Molina de la Torre, Antonio José O'Callaghan Gordo, Cristina Alonso Aguado, Maria Henar Rodríguez Suárez, Marta María Mirón Pozo, Benito Alguacil, Juan Gómez Acebo, Inés Ascunce, Nieves Vanaclocha Espi, Mercedes Amiano, Pilar Chirlaque, María Dolores Simó, Vicente Jiménez Moleón, José Juan Tardón, Adonina Moreno Aguado, Víctor Castaño-Vinyals, Gemma Martín Sánchez, Vicente Aragonès Sanz, Núria Pérez Gómez, Beatriz Kogevinas, Manolis Pollán, Marina |
| author |
García Pérez, Javier |
| author_facet |
García Pérez, Javier Fernández de Larrea Baz, Nerea Lope, Virginia Molina de la Torre, Antonio José O'Callaghan Gordo, Cristina Alonso Aguado, Maria Henar Rodríguez Suárez, Marta María Mirón Pozo, Benito Alguacil, Juan Gómez Acebo, Inés Ascunce, Nieves Vanaclocha Espi, Mercedes Amiano, Pilar Chirlaque, María Dolores Simó, Vicente Jiménez Moleón, José Juan Tardón, Adonina Moreno Aguado, Víctor Castaño-Vinyals, Gemma Martín Sánchez, Vicente Aragonès Sanz, Núria Pérez Gómez, Beatriz Kogevinas, Manolis Pollán, Marina |
| author_role |
author |
| author2 |
Fernández de Larrea Baz, Nerea Lope, Virginia Molina de la Torre, Antonio José O'Callaghan Gordo, Cristina Alonso Aguado, Maria Henar Rodríguez Suárez, Marta María Mirón Pozo, Benito Alguacil, Juan Gómez Acebo, Inés Ascunce, Nieves Vanaclocha Espi, Mercedes Amiano, Pilar Chirlaque, María Dolores Simó, Vicente Jiménez Moleón, José Juan Tardón, Adonina Moreno Aguado, Víctor Castaño-Vinyals, Gemma Martín Sánchez, Vicente Aragonès Sanz, Núria Pérez Gómez, Beatriz Kogevinas, Manolis Pollán, Marina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Càncer colorectal Contaminació atmosfèrica Zones industrials Colorectal cancer Atmospheric pollution Industrial sites |
| topic |
Càncer colorectal Contaminació atmosfèrica Zones industrials Colorectal cancer Atmospheric pollution Industrial sites |
| description |
Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects' residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44-2.87) to 3 km (1.26; 1.00-1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (<= 3 km) production of metals (2.66; 1.77-4.00), surface treatment of metals (1.48; 1.08-2.02), glass and mineral fibers (2.06; 1.39-3.07), organic chemical industry (4.80; 3.20-7.20), inorganic chemical industry (6.74; 4.38-10.36), food/beverage sector (3.34; 2.38-4.68), and surface treatment using organic solvents (6.16; 4.06-9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (<= 3 km) industries releasing nonylphenol (9.19; 5.91-14.28), antimony (5.30; 3.45-8.15), naphthalene (3.11; 2.16-4.49), organotin compounds (2.64; 1.76-3.98), manganese (2.53; 1.63-3.93), dichloromethane (2.52; 1.74-3.66), and vanadium (2.49; 1.59-3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/174252 |
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https://hdl.handle.net/2445/174252 |
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Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1016/j.envint.2020.106055 Environment International, 2020, vol. 144, p. 106055 https://doi.org/10.1016/j.envint.2020.106055 |
| dc.rights.none.fl_str_mv |
cc by-nc-nd (c) García Pérez et al., 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by-nc-nd (c) García Pérez et al., 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Articles publicats en revistes (Ciències Clíniques) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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1869410276569251840 |
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15.300719 |