Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states.
The thalamus is known to play a key role in arousal regulation and support of human consciousness. Neuropathological studies have identified thalamic damage as one of the most common abnormalities present in the brains of patients who were in a vegetative state (VS) or a minimally-conscious state (M...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/223692 |
| Acceso en línea: | https://hdl.handle.net/2445/223692 |
| Access Level: | acceso abierto |
| Palabra clave: | Localitzacions cerebrals Neuroanatomia Mapatge del cervell Lesions cerebrals Localization of cerebral functions Neuroanatomy Brain mapping Brain damage |
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Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states.Fernández Espejo, DaviniaJunqué i Plaja, Carme, 1955-Bernabeu Guitart, MontserratRoig Rovira, María TeresaVendrell i Gómez, PereMercader Sobrequés, José Ma.Localitzacions cerebralsNeuroanatomiaMapatge del cervellLesions cerebralsLocalization of cerebral functionsNeuroanatomyBrain mappingBrain damageThe thalamus is known to play a key role in arousal regulation and support of human consciousness. Neuropathological studies have identified thalamic damage as one of the most common abnormalities present in the brains of patients who were in a vegetative state (VS) or a minimally-conscious state (MCS) state at the time of their deaths. Nonetheless, no in vivo studies of thalamic abnormalities in these patients have been conducted. Using high-resolution T1-weighted magnetic resonance images and a novel approach to shape analysis, we investigated thalamic global and regional changes in a sample of patients in a VS or an MCS. Group comparisons and correlations with clinical variables were performed for the total thalamic volume and for each surface vertex. Total thalamic volume was significantly lower in patients than in healthy volunteers. Shape analysis revealed significant bilateral regional atrophy in the dorso-medial body in patients compared to controls; this atrophy was more widespread in VS than in MCS patients. Lower thalamic volume was significantly correlated with worse Disability Rating Scale scores. Shape analysis suggested that the dorso-medial nucleus and the internal medullar lamina were the main regions responsible for this correlation. Our findings suggest that MCS and VS patients present different patterns of regional thalamic abnormalities, and that these differences partially explain their clinical profile.Mary Ann Liebert2025202520102025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/223692Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1089/neu.2010.1297Journal of Neurotrauma, 2010, vol. 27, num.7, p. 1187-1193https://doi.org/10.1089/neu.2010.1297(c) Mary Ann Liebert, 2010info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2236922026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| title |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| spellingShingle |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. Fernández Espejo, Davinia Localitzacions cerebrals Neuroanatomia Mapatge del cervell Lesions cerebrals Localization of cerebral functions Neuroanatomy Brain mapping Brain damage |
| title_short |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| title_full |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| title_fullStr |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| title_full_unstemmed |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| title_sort |
Reductions of thalamic volue and regiona shape changes in the vegetative and the minimally concious states. |
| dc.creator.none.fl_str_mv |
Fernández Espejo, Davinia Junqué i Plaja, Carme, 1955- Bernabeu Guitart, Montserrat Roig Rovira, María Teresa Vendrell i Gómez, Pere Mercader Sobrequés, José Ma. |
| author |
Fernández Espejo, Davinia |
| author_facet |
Fernández Espejo, Davinia Junqué i Plaja, Carme, 1955- Bernabeu Guitart, Montserrat Roig Rovira, María Teresa Vendrell i Gómez, Pere Mercader Sobrequés, José Ma. |
| author_role |
author |
| author2 |
Junqué i Plaja, Carme, 1955- Bernabeu Guitart, Montserrat Roig Rovira, María Teresa Vendrell i Gómez, Pere Mercader Sobrequés, José Ma. |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
Localitzacions cerebrals Neuroanatomia Mapatge del cervell Lesions cerebrals Localization of cerebral functions Neuroanatomy Brain mapping Brain damage |
| topic |
Localitzacions cerebrals Neuroanatomia Mapatge del cervell Lesions cerebrals Localization of cerebral functions Neuroanatomy Brain mapping Brain damage |
| description |
The thalamus is known to play a key role in arousal regulation and support of human consciousness. Neuropathological studies have identified thalamic damage as one of the most common abnormalities present in the brains of patients who were in a vegetative state (VS) or a minimally-conscious state (MCS) state at the time of their deaths. Nonetheless, no in vivo studies of thalamic abnormalities in these patients have been conducted. Using high-resolution T1-weighted magnetic resonance images and a novel approach to shape analysis, we investigated thalamic global and regional changes in a sample of patients in a VS or an MCS. Group comparisons and correlations with clinical variables were performed for the total thalamic volume and for each surface vertex. Total thalamic volume was significantly lower in patients than in healthy volunteers. Shape analysis revealed significant bilateral regional atrophy in the dorso-medial body in patients compared to controls; this atrophy was more widespread in VS than in MCS patients. Lower thalamic volume was significantly correlated with worse Disability Rating Scale scores. Shape analysis suggested that the dorso-medial nucleus and the internal medullar lamina were the main regions responsible for this correlation. Our findings suggest that MCS and VS patients present different patterns of regional thalamic abnormalities, and that these differences partially explain their clinical profile. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/223692 |
| url |
https://hdl.handle.net/2445/223692 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1089/neu.2010.1297 Journal of Neurotrauma, 2010, vol. 27, num.7, p. 1187-1193 https://doi.org/10.1089/neu.2010.1297 |
| dc.rights.none.fl_str_mv |
(c) Mary Ann Liebert, 2010 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Mary Ann Liebert, 2010 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
7 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
| publisher.none.fl_str_mv |
Mary Ann Liebert |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15.811543 |