Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery
The objective of this prospective, single-centre case series was to investigate feasibility, clinical outcomes, and neural correlates of non-invasive Neuromodulation-Induced Cortical Prehabilitation (NICP) before brain tumor surgery. Previous studies have shown that gross total resection is paramoun...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:304943 |
| Acceso en línea: | https://ddd.uab.cat/record/304943 https://dx.doi.org/urn:doi:10.1007/s11060-024-04774-4 |
| Access Level: | acceso abierto |
| Palabra clave: | Brain tumor Prehabilitation Neurorehabilitation Neuromodulation Neurosurgery Case series |
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Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgerylessons from a case seriesBoccuni, Leonardo|||0000-0001-7385-5219Roca-Ventura, Alba|||0000-0002-9138-4294Buloz-Osorio, Edgar|||0000-0003-3079-0122Leno-Colorado, DavidDelgado-Gallén, Selma|||0000-0003-3763-9775Cabello-Toscano, María|||0000-0001-5066-3476Perellón-Alfonso, Ruben|||0000-0001-8647-3703Villalba-Martínez, GloriaMartinez-Ricarte, Fran|||0000-0003-4567-0828Martín-Fernández, Jesús|||0000-0001-9545-1549Buxeda-Rodriguez, MònicaConesa-Bertrán, GerardoIllueca-Moreno, MireiaLladó-Carbó, EstelaPerla y Perla, CristóbalGarrido, CésarPariente, José CarlosLaredo, Carlos|||0000-0002-4626-6360Muñoz-Moreno, Emma|||0000-0003-2104-7265Bargalló, Núria|||0000-0001-6284-5402Trompetto, CarloMarinelli, Lucio|||0000-0003-0620-7654Bartrés-Faz, David|||0000-0001-6020-4118Abellaneda Pérez, Kilian|||0000-0001-6447-1248Pascual Leone, Álvaro|||0000-0001-8975-0382Tormos, Jose M.|||0000-0002-8764-2289Brain tumorPrehabilitationNeurorehabilitationNeuromodulationNeurosurgeryCase seriesThe objective of this prospective, single-centre case series was to investigate feasibility, clinical outcomes, and neural correlates of non-invasive Neuromodulation-Induced Cortical Prehabilitation (NICP) before brain tumor surgery. Previous studies have shown that gross total resection is paramount to increase life expectancy but is counterbalanced by the need of preserving critical functional areas. NICP aims at expanding functional margins for extensive tumor resection without functional sequelae. Invasive NICP (intracranial neuromodulation) was effective but characterized by elevated costs and high rate of adverse events. Non-invasive NICP (transcranial neuromodulation) may represent a more feasible alternative. Nonetheless, up to this point, non-invasive NICP has been examined in only two case reports, yielding inconclusive findings. Treatment sessions consisted of non-invasive neuromodulation, to transiently deactivate critical areas adjacent to the lesion, coupled with intensive functional training, to activate alternative nodes within the same functional network. Patients were evaluated pre-NICP, post-NICP, and at follow-up post-surgery. Ten patients performed the intervention. Feasibility criteria were met (retention, adherence, safety, and patient's satisfaction). Clinical outcomes showed overall stability and improvements in motor and executive function from pre- to post-NICP, and at follow-up. Relevant plasticity changes (increase in the distance between tumor and critical area) were observed when the neuromodulation target was guided by functional neuroimaging data. This is the first case series demonstrating feasibility of non-invasive NICP. Neural correlates indicate that neuroimaging-guided target selection may represent a valid strategy to leverage neuroplastic changes before neurosurgery. Further investigations are needed to confirm such preliminary findings. The online version contains supplementary material available at 10.1007/s11060-024-04774-4. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/304943https://dx.doi.org/urn:doi:10.1007/s11060-024-04774-4reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 IBPS15-EE-3688Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2021-047380-Iopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3049432026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery lessons from a case series |
| title |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery |
| spellingShingle |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery Boccuni, Leonardo|||0000-0001-7385-5219 Brain tumor Prehabilitation Neurorehabilitation Neuromodulation Neurosurgery Case series |
| title_short |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery |
| title_full |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery |
| title_fullStr |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery |
| title_full_unstemmed |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery |
| title_sort |
Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery |
| dc.creator.none.fl_str_mv |
Boccuni, Leonardo|||0000-0001-7385-5219 Roca-Ventura, Alba|||0000-0002-9138-4294 Buloz-Osorio, Edgar|||0000-0003-3079-0122 Leno-Colorado, David Delgado-Gallén, Selma|||0000-0003-3763-9775 Cabello-Toscano, María|||0000-0001-5066-3476 Perellón-Alfonso, Ruben|||0000-0001-8647-3703 Villalba-Martínez, Gloria Martinez-Ricarte, Fran|||0000-0003-4567-0828 Martín-Fernández, Jesús|||0000-0001-9545-1549 Buxeda-Rodriguez, Mònica Conesa-Bertrán, Gerardo Illueca-Moreno, Mireia Lladó-Carbó, Estela Perla y Perla, Cristóbal Garrido, César Pariente, José Carlos Laredo, Carlos|||0000-0002-4626-6360 Muñoz-Moreno, Emma|||0000-0003-2104-7265 Bargalló, Núria|||0000-0001-6284-5402 Trompetto, Carlo Marinelli, Lucio|||0000-0003-0620-7654 Bartrés-Faz, David|||0000-0001-6020-4118 Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Pascual Leone, Álvaro|||0000-0001-8975-0382 Tormos, Jose M.|||0000-0002-8764-2289 |
| author |
Boccuni, Leonardo|||0000-0001-7385-5219 |
| author_facet |
Boccuni, Leonardo|||0000-0001-7385-5219 Roca-Ventura, Alba|||0000-0002-9138-4294 Buloz-Osorio, Edgar|||0000-0003-3079-0122 Leno-Colorado, David Delgado-Gallén, Selma|||0000-0003-3763-9775 Cabello-Toscano, María|||0000-0001-5066-3476 Perellón-Alfonso, Ruben|||0000-0001-8647-3703 Villalba-Martínez, Gloria Martinez-Ricarte, Fran|||0000-0003-4567-0828 Martín-Fernández, Jesús|||0000-0001-9545-1549 Buxeda-Rodriguez, Mònica Conesa-Bertrán, Gerardo Illueca-Moreno, Mireia Lladó-Carbó, Estela Perla y Perla, Cristóbal Garrido, César Pariente, José Carlos Laredo, Carlos|||0000-0002-4626-6360 Muñoz-Moreno, Emma|||0000-0003-2104-7265 Bargalló, Núria|||0000-0001-6284-5402 Trompetto, Carlo Marinelli, Lucio|||0000-0003-0620-7654 Bartrés-Faz, David|||0000-0001-6020-4118 Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Pascual Leone, Álvaro|||0000-0001-8975-0382 Tormos, Jose M.|||0000-0002-8764-2289 |
| author_role |
author |
| author2 |
Roca-Ventura, Alba|||0000-0002-9138-4294 Buloz-Osorio, Edgar|||0000-0003-3079-0122 Leno-Colorado, David Delgado-Gallén, Selma|||0000-0003-3763-9775 Cabello-Toscano, María|||0000-0001-5066-3476 Perellón-Alfonso, Ruben|||0000-0001-8647-3703 Villalba-Martínez, Gloria Martinez-Ricarte, Fran|||0000-0003-4567-0828 Martín-Fernández, Jesús|||0000-0001-9545-1549 Buxeda-Rodriguez, Mònica Conesa-Bertrán, Gerardo Illueca-Moreno, Mireia Lladó-Carbó, Estela Perla y Perla, Cristóbal Garrido, César Pariente, José Carlos Laredo, Carlos|||0000-0002-4626-6360 Muñoz-Moreno, Emma|||0000-0003-2104-7265 Bargalló, Núria|||0000-0001-6284-5402 Trompetto, Carlo Marinelli, Lucio|||0000-0003-0620-7654 Bartrés-Faz, David|||0000-0001-6020-4118 Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Pascual Leone, Álvaro|||0000-0001-8975-0382 Tormos, Jose M.|||0000-0002-8764-2289 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Brain tumor Prehabilitation Neurorehabilitation Neuromodulation Neurosurgery Case series |
| topic |
Brain tumor Prehabilitation Neurorehabilitation Neuromodulation Neurosurgery Case series |
| description |
The objective of this prospective, single-centre case series was to investigate feasibility, clinical outcomes, and neural correlates of non-invasive Neuromodulation-Induced Cortical Prehabilitation (NICP) before brain tumor surgery. Previous studies have shown that gross total resection is paramount to increase life expectancy but is counterbalanced by the need of preserving critical functional areas. NICP aims at expanding functional margins for extensive tumor resection without functional sequelae. Invasive NICP (intracranial neuromodulation) was effective but characterized by elevated costs and high rate of adverse events. Non-invasive NICP (transcranial neuromodulation) may represent a more feasible alternative. Nonetheless, up to this point, non-invasive NICP has been examined in only two case reports, yielding inconclusive findings. Treatment sessions consisted of non-invasive neuromodulation, to transiently deactivate critical areas adjacent to the lesion, coupled with intensive functional training, to activate alternative nodes within the same functional network. Patients were evaluated pre-NICP, post-NICP, and at follow-up post-surgery. Ten patients performed the intervention. Feasibility criteria were met (retention, adherence, safety, and patient's satisfaction). Clinical outcomes showed overall stability and improvements in motor and executive function from pre- to post-NICP, and at follow-up. Relevant plasticity changes (increase in the distance between tumor and critical area) were observed when the neuromodulation target was guided by functional neuroimaging data. This is the first case series demonstrating feasibility of non-invasive NICP. Neural correlates indicate that neuroimaging-guided target selection may represent a valid strategy to leverage neuroplastic changes before neurosurgery. Further investigations are needed to confirm such preliminary findings. The online version contains supplementary material available at 10.1007/s11060-024-04774-4. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/304943 https://dx.doi.org/urn:doi:10.1007/s11060-024-04774-4 |
| url |
https://ddd.uab.cat/record/304943 https://dx.doi.org/urn:doi:10.1007/s11060-024-04774-4 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 IBPS15-EE-3688 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2021-047380-I |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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