Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia

COVID-19; Hemoadsorption; Hypercytokinemia

Detalhes bibliográficos
Autores: Ruiz Rodriguez, Juan Carlos, Chiscano Camon, Luis Silvestre, Ruiz Sanmartin, Adolfo, Palmada Ibars, Clara, Plata Menchaca, Erika Paola, Franco Jarava, Clara, Pérez Carrasco, Marcos, Hernández González, Manuel, Ferrer Roca, Ricard
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7827
Acesso em linha:https://hdl.handle.net/11351/7827
Access Level:acceso abierto
Palavra-chave:COVID-19 (Malaltia) - Tractament
Citocines
Pneumònia vírica - Tractament
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/therapy
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/terapia
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
title Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
spellingShingle Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
Ruiz Rodriguez, Juan Carlos
COVID-19 (Malaltia) - Tractament
Citocines
Pneumònia vírica - Tractament
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/therapy
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/terapia
title_short Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
title_full Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
title_fullStr Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
title_full_unstemmed Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
title_sort Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
dc.creator.none.fl_str_mv Ruiz Rodriguez, Juan Carlos
Chiscano Camon, Luis Silvestre
Ruiz Sanmartin, Adolfo
Palmada Ibars, Clara
Plata Menchaca, Erika Paola
Franco Jarava, Clara
Pérez Carrasco, Marcos
Hernández González, Manuel
Ferrer Roca, Ricard
author Ruiz Rodriguez, Juan Carlos
author_facet Ruiz Rodriguez, Juan Carlos
Chiscano Camon, Luis Silvestre
Ruiz Sanmartin, Adolfo
Palmada Ibars, Clara
Plata Menchaca, Erika Paola
Franco Jarava, Clara
Pérez Carrasco, Marcos
Hernández González, Manuel
Ferrer Roca, Ricard
author_role author
author2 Chiscano Camon, Luis Silvestre
Ruiz Sanmartin, Adolfo
Palmada Ibars, Clara
Plata Menchaca, Erika Paola
Franco Jarava, Clara
Pérez Carrasco, Marcos
Hernández González, Manuel
Ferrer Roca, Ricard
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Ruiz-Rodríguez JC, Chiscano-Camón L, Ferrer R] Unitat de Cures Intensives, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Xoc, Disfunció Orgànica i Ressuscitació, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ruiz-Sanmartin A, Palmada C, Plata-Menchaca EP, Pérez-Carrasco M] Unitat de Cures Intensives, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Xoc, Disfunció Orgànica i Ressuscitació, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Jarava C, Hernández-González M] Servei d’Immunologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv COVID-19 (Malaltia) - Tractament
Citocines
Pneumònia vírica - Tractament
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/therapy
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/terapia
topic COVID-19 (Malaltia) - Tractament
Citocines
Pneumònia vírica - Tractament
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/therapy
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/terapia
description COVID-19; Hemoadsorption; Hypercytokinemia
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7827
url https://hdl.handle.net/11351/7827
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Medicine;8
https://doi.org/10.3389/fmed.2021.779038
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410236107849728
spelling Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and HypercytokinemiaRuiz Rodriguez, Juan CarlosChiscano Camon, Luis SilvestreRuiz Sanmartin, AdolfoPalmada Ibars, ClaraPlata Menchaca, Erika PaolaFranco Jarava, ClaraPérez Carrasco, MarcosHernández González, ManuelFerrer Roca, RicardCOVID-19 (Malaltia) - TractamentCitocinesPneumònia vírica - TractamentDISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus InfectionsOther subheadings::Other subheadings::Other subheadings::/therapyENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por CoronavirusOtros calificadores::Otros calificadores::Otros calificadores::/terapiaCOVID-19; Hemoadsorption; HypercytokinemiaCOVID-19; Hemoadsorción; HipercitoquinemiaCOVID-19; Hemoadsorció; HipercitocinèmiaIntroduction: A dysregulated inflammatory response, known as “cytokine storm”, plays an important role in the pathophysiology of coronavirus 2019 disease (COVID-19). Identifying patients with a dysregulated inflammatory response and at high risk for severe respiratory failure, organ dysfunction, and death is clinically relevant, as they could benefit from the specific therapies, such as cytokine removal by hemoadsorption. This study aimed to evaluate cytokine hemoadsorption as rescue therapy in critically ill patients with SARS-CoV-2 pneumonia, severe respiratory failure refractory to prone positioning, and hypercytokinemia. Methods: In this single center, observational and retrospective study, critically ill patients with SARS-CoV-2 pneumonia, severe acute respiratory failure, and hypercytokinemia were analyzed. All the patients underwent cytokine hemoadsorption using CytoSorb® (Cytosorbents Europe, Berlin, Germany). The indication for treatment was acute respiratory failure, inadequate clinical response to the prone position, and hypercytokinemia. Results: Among a total of 343 patients who were admitted to the intensive care unit (ICU) due to SARS-CoV-2 infection between March 3, 2020 and June 22, 2020, six patients received rescue therapy with cytokine hemoadsorption. All the patients needed invasive mechanical ventilation and prone positioning. A significant difference was found in the pre- and post-treatment D-dimer (17,868 mcg/ml [4,196–45,287] vs. 4,488 mcg/ml [3,166–17,076], p = 0.046), C-reactive protein (12.9 mg/dl [10.6] vs. 3.5 mg/dl [2.8], p = 0.028), ferritin (1,539 mcg/L [764–27,414] vs. 1,197 ng/ml [524–3,857], p = 0.04) and interleukin-6 (17,367 pg/ml [4,539–22,532] vs. 2,403 pg/ml [917–3,724], p = 0.043) levels. No significant differences in the pre- and post-treatment interleukin-10 levels (22.3 pg/ml [19.2–191] vs. 5.6 pg/ml [5.2–36.6], p = 0.068) were observed. Improvements in oxygenation (prehemoadsorption PaO2/FIO2 ratio 103 [18.4] vs. posthemoadsorption PaO2/FIO2 ratio 222 [20.9], p = 0.029) and in the organ dysfunction (prehemoadsorption SOFA score 9 [4.75] vs. posthemoadsorption SOFA score 7.7 [5.4], p = 0.046) were observed. ICU and in-hospital mortality was 33.7%. Conclusions: In this case series, critically ill patients with COVID-19 with severe acute respiratory failure refractory to prone positioning and hypercytokinemia who received adjuvant treatment with cytokine hemoadsorption showed a significant reduction in IL-6 plasma levels and other inflammatory biomarkers. Improvements in oxygenation and SOFA score were also observed.Frontiers MediaInstitut Català de la Salut[Ruiz-Rodríguez JC, Chiscano-Camón L, Ferrer R] Unitat de Cures Intensives, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Xoc, Disfunció Orgànica i Ressuscitació, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ruiz-Sanmartin A, Palmada C, Plata-Menchaca EP, Pérez-Carrasco M] Unitat de Cures Intensives, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Xoc, Disfunció Orgànica i Ressuscitació, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Jarava C, Hernández-González M] Servei d’Immunologia, Vall d'Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7827Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Medicine;8https://doi.org/10.3389/fmed.2021.779038Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/78272026-06-12T09:38:37Z
score 15.81155

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