ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer

Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human...

Descripción completa

Detalles Bibliográficos
Autores: Cedó, Lídia|||0000-0003-4354-3411, Garcia León, Annabel|||0000-0003-3007-9306, Baila-Rueda, Lucía, Santos, David|||0000-0003-1157-4969, Grijalva, Victor, Martínez Cignoni, Melanie Raquel|||0000-0002-3469-7980, Carbó, José María|||0000-0001-8301-5360, Metso, Jari, López Vilaró, Laura|||0000-0002-5428-8017, Zorzano Olarte, Antonio|||0000-0002-1638-0306, Valledor, Annabel F.|||0000-0003-4232-2633, Cenarro, Ana, Jauhiainen, Matti|||0000-0002-3836-3785, Lerma Puertas, Enrique|||0000-0001-7908-2747, Fogelman, Alan M., Reddy, Srinivasa T., Escolà-Gil, Joan Carles|||0000-0001-9021-2485, Blanco Vaca, Francisco|||0000-0001-7380-5385
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:203755
Acceso en línea:https://ddd.uab.cat/record/203755
https://dx.doi.org/urn:doi:10.1038/srep36387
Access Level:acceso abierto
Palabra clave:Animals
Antineoplastic Agents
Apolipoprotein A-I
Breast Neoplasms
Cell Proliferation
Cell Survival
Female
Humans
Lipoproteins, LDL
MCF-7 Cells
Mice
Mice, Transgenic
Molecular Mimicry
Peptides
Xenograft Model Antitumor Assays
id ES_6bf5a030d2616c7d6c323101f9497639
oai_identifier_str oai:ddd.uab.cat:203755
network_acronym_str ES
network_name_str España
repository_id_str
spelling ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancerCedó, Lídia|||0000-0003-4354-3411Garcia León, Annabel|||0000-0003-3007-9306Baila-Rueda, LucíaSantos, David|||0000-0003-1157-4969Grijalva, VictorMartínez Cignoni, Melanie Raquel|||0000-0002-3469-7980Carbó, José María|||0000-0001-8301-5360Metso, JariLópez Vilaró, Laura|||0000-0002-5428-8017Zorzano Olarte, Antonio|||0000-0002-1638-0306Valledor, Annabel F.|||0000-0003-4232-2633Cenarro, AnaJauhiainen, Matti|||0000-0002-3836-3785Lerma Puertas, Enrique|||0000-0001-7908-2747Fogelman, Alan M.Reddy, Srinivasa T.Escolà-Gil, Joan Carles|||0000-0001-9021-2485Blanco Vaca, Francisco|||0000-0001-7380-5385AnimalsAntineoplastic AgentsApolipoprotein A-IBreast NeoplasmsCell ProliferationCell SurvivalFemaleHumansLipoproteins, LDLMCF-7 CellsMiceMice, TransgenicMolecular MimicryPeptidesXenograft Model Antitumor AssaysLow levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification.Universitat Autònoma de Barcelona 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/203755https://dx.doi.org/urn:doi:10.1038/srep36387reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01076Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI12/00291Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/02507Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12-0042-0055Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2011-23402open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2037552026-06-06T12:50:31Z
dc.title.none.fl_str_mv ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
title ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
spellingShingle ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
Cedó, Lídia|||0000-0003-4354-3411
Animals
Antineoplastic Agents
Apolipoprotein A-I
Breast Neoplasms
Cell Proliferation
Cell Survival
Female
Humans
Lipoproteins, LDL
MCF-7 Cells
Mice
Mice, Transgenic
Molecular Mimicry
Peptides
Xenograft Model Antitumor Assays
title_short ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
title_full ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
title_fullStr ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
title_full_unstemmed ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
title_sort ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
dc.creator.none.fl_str_mv Cedó, Lídia|||0000-0003-4354-3411
Garcia León, Annabel|||0000-0003-3007-9306
Baila-Rueda, Lucía
Santos, David|||0000-0003-1157-4969
Grijalva, Victor
Martínez Cignoni, Melanie Raquel|||0000-0002-3469-7980
Carbó, José María|||0000-0001-8301-5360
Metso, Jari
López Vilaró, Laura|||0000-0002-5428-8017
Zorzano Olarte, Antonio|||0000-0002-1638-0306
Valledor, Annabel F.|||0000-0003-4232-2633
Cenarro, Ana
Jauhiainen, Matti|||0000-0002-3836-3785
Lerma Puertas, Enrique|||0000-0001-7908-2747
Fogelman, Alan M.
Reddy, Srinivasa T.
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Blanco Vaca, Francisco|||0000-0001-7380-5385
author Cedó, Lídia|||0000-0003-4354-3411
author_facet Cedó, Lídia|||0000-0003-4354-3411
Garcia León, Annabel|||0000-0003-3007-9306
Baila-Rueda, Lucía
Santos, David|||0000-0003-1157-4969
Grijalva, Victor
Martínez Cignoni, Melanie Raquel|||0000-0002-3469-7980
Carbó, José María|||0000-0001-8301-5360
Metso, Jari
López Vilaró, Laura|||0000-0002-5428-8017
Zorzano Olarte, Antonio|||0000-0002-1638-0306
Valledor, Annabel F.|||0000-0003-4232-2633
Cenarro, Ana
Jauhiainen, Matti|||0000-0002-3836-3785
Lerma Puertas, Enrique|||0000-0001-7908-2747
Fogelman, Alan M.
Reddy, Srinivasa T.
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Blanco Vaca, Francisco|||0000-0001-7380-5385
author_role author
author2 Garcia León, Annabel|||0000-0003-3007-9306
Baila-Rueda, Lucía
Santos, David|||0000-0003-1157-4969
Grijalva, Victor
Martínez Cignoni, Melanie Raquel|||0000-0002-3469-7980
Carbó, José María|||0000-0001-8301-5360
Metso, Jari
López Vilaró, Laura|||0000-0002-5428-8017
Zorzano Olarte, Antonio|||0000-0002-1638-0306
Valledor, Annabel F.|||0000-0003-4232-2633
Cenarro, Ana
Jauhiainen, Matti|||0000-0002-3836-3785
Lerma Puertas, Enrique|||0000-0001-7908-2747
Fogelman, Alan M.
Reddy, Srinivasa T.
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Blanco Vaca, Francisco|||0000-0001-7380-5385
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Animals
Antineoplastic Agents
Apolipoprotein A-I
Breast Neoplasms
Cell Proliferation
Cell Survival
Female
Humans
Lipoproteins, LDL
MCF-7 Cells
Mice
Mice, Transgenic
Molecular Mimicry
Peptides
Xenograft Model Antitumor Assays
topic Animals
Antineoplastic Agents
Apolipoprotein A-I
Breast Neoplasms
Cell Proliferation
Cell Survival
Female
Humans
Lipoproteins, LDL
MCF-7 Cells
Mice
Mice, Transgenic
Molecular Mimicry
Peptides
Xenograft Model Antitumor Assays
description Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/203755
https://dx.doi.org/urn:doi:10.1038/srep36387
url https://ddd.uab.cat/record/203755
https://dx.doi.org/urn:doi:10.1038/srep36387
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01076
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI12/00291
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/02507
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12-0042-0055
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2011-23402
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410234175324160
score 15,300719

Similares en LA Referencia