Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

Background: To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures. Methods: The records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials usin...

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Autores: Cihoric, Nikola, Tsikkinis, Alexandros, Gutiérrez Miguélez, Cristina, Strnad, Vratislav, Soldatovic, Ivan, Ghadjar, Pirus, Jeremic, Branislav, Pra, Alan Dal, Aebersold, Daniel M., Lössl, Kristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126870
Acceso en línea:https://hdl.handle.net/2445/126870
Access Level:acceso abierto
Palabra clave:Braquiteràpia
Assaigs clínics
Radioisotope brachytherapy
Clinical trials
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spelling Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov databaseCihoric, NikolaTsikkinis, AlexandrosGutiérrez Miguélez, CristinaStrnad, VratislavSoldatovic, IvanGhadjar, PirusJeremic, BranislavPra, Alan DalAebersold, Daniel M.Lössl, KristinaBraquiteràpiaAssaigs clínicsRadioisotope brachytherapyClinical trialsBackground: To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures. Methods: The records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials using BT as an intervention were identified for further analyses. The selected trials were manually categorized according to indication(s), BT source, applied dose rate, primary sponsor type, location, protocol initiator and funding source. We analyzed trials across 8 available trial protocol elements registered within the database. Results: In total 245 clinical trials were identified, 147 with BT as primary investigated treatment modality and 98 that included BT as an optional treatment component or as part of the standard treatment. Academic centers were the most frequent protocol initiators in trials where BT was the primary investigational treatment modality (p<0.01). High dose rate (HDR) BT was the most frequently investigated type of BT dose rate (46.3 %) followed by low dose rate (LDR) (42.0 %). Prostate was the most frequently investigated tumor entity in trials with BT as the primary treatment modality (40.1 %) followed by breast cancer (17.0 %). BT was rarely the primary investigated treatment modality for cervical cancer (6.8 %). Conclusion: Most clinical trials using BT are predominantly in early phases, investigator-initiated and with low accrual numbers. Current investigational activities that include BT mainly focus on prostate and breast cancers. Important questions concerning the optimal usage of BT will not be answered in the near future.BioMed Central2018201820162018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/126870Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13014-016-0624-8Radiation Oncology, 2016, Vol. 11, num. 48https://doi.org/10.1186/s13014-016-0624-8cc by (c) Cihoric et al., 2016http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1268702026-05-29T05:05:01Z
dc.title.none.fl_str_mv Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
title Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
spellingShingle Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
Cihoric, Nikola
Braquiteràpia
Assaigs clínics
Radioisotope brachytherapy
Clinical trials
title_short Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
title_full Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
title_fullStr Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
title_full_unstemmed Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
title_sort Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
dc.creator.none.fl_str_mv Cihoric, Nikola
Tsikkinis, Alexandros
Gutiérrez Miguélez, Cristina
Strnad, Vratislav
Soldatovic, Ivan
Ghadjar, Pirus
Jeremic, Branislav
Pra, Alan Dal
Aebersold, Daniel M.
Lössl, Kristina
author Cihoric, Nikola
author_facet Cihoric, Nikola
Tsikkinis, Alexandros
Gutiérrez Miguélez, Cristina
Strnad, Vratislav
Soldatovic, Ivan
Ghadjar, Pirus
Jeremic, Branislav
Pra, Alan Dal
Aebersold, Daniel M.
Lössl, Kristina
author_role author
author2 Tsikkinis, Alexandros
Gutiérrez Miguélez, Cristina
Strnad, Vratislav
Soldatovic, Ivan
Ghadjar, Pirus
Jeremic, Branislav
Pra, Alan Dal
Aebersold, Daniel M.
Lössl, Kristina
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Braquiteràpia
Assaigs clínics
Radioisotope brachytherapy
Clinical trials
topic Braquiteràpia
Assaigs clínics
Radioisotope brachytherapy
Clinical trials
description Background: To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures. Methods: The records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials using BT as an intervention were identified for further analyses. The selected trials were manually categorized according to indication(s), BT source, applied dose rate, primary sponsor type, location, protocol initiator and funding source. We analyzed trials across 8 available trial protocol elements registered within the database. Results: In total 245 clinical trials were identified, 147 with BT as primary investigated treatment modality and 98 that included BT as an optional treatment component or as part of the standard treatment. Academic centers were the most frequent protocol initiators in trials where BT was the primary investigational treatment modality (p<0.01). High dose rate (HDR) BT was the most frequently investigated type of BT dose rate (46.3 %) followed by low dose rate (LDR) (42.0 %). Prostate was the most frequently investigated tumor entity in trials with BT as the primary treatment modality (40.1 %) followed by breast cancer (17.0 %). BT was rarely the primary investigated treatment modality for cervical cancer (6.8 %). Conclusion: Most clinical trials using BT are predominantly in early phases, investigator-initiated and with low accrual numbers. Current investigational activities that include BT mainly focus on prostate and breast cancers. Important questions concerning the optimal usage of BT will not be answered in the near future.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126870
url https://hdl.handle.net/2445/126870
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s13014-016-0624-8
Radiation Oncology, 2016, Vol. 11, num. 48
https://doi.org/10.1186/s13014-016-0624-8
dc.rights.none.fl_str_mv cc by (c) Cihoric et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Cihoric et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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