Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities

Calcification is a process of accumulation of calcium in tissues and deposition of calcium salts by the crystallization of PO43− and ionized calcium (Ca2+). It is a crucial process in the development of bones and teeth. However, pathological calcification can occur in almost any soft tissue of the o...

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Detalles Bibliográficos
Autores: Ortega, Miguel A., Gimeno Longas, María José, Saez, Miguel A.
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/107111
Acceso en línea:https://hdl.handle.net/20.500.14352/107111
Access Level:acceso abierto
Palabra clave:611.018
vascular calcification
signaling pathways
endothelial cells (ECs)
vascular smooth muscle cells (VSMCs)
biomarkers
Ciencias Biomédicas
32 Ciencias Médicas
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spelling Vascular Calcification: Molecular Networking, Pathological Implications and Translational OpportunitiesOrtega, Miguel A.Gimeno Longas, María JoséSaez, Miguel A.611.018vascular calcificationsignaling pathwaysendothelial cells (ECs)vascular smooth muscle cells (VSMCs)biomarkersCiencias Biomédicas32 Ciencias MédicasCalcification is a process of accumulation of calcium in tissues and deposition of calcium salts by the crystallization of PO43− and ionized calcium (Ca2+). It is a crucial process in the development of bones and teeth. However, pathological calcification can occur in almost any soft tissue of the organism. The better studied is vascular calcification, where calcium salts can accumulate in the intima or medial layer or in aortic valves, and it is associated with higher mortality and cardiovascular events, including myocardial infarction, stroke, aortic and peripheral artery disease (PAD), and diabetes or chronic kidney disease (CKD), among others. The process involves an intricate interplay of different cellular components, endothelial cells (ECs), vascular smooth muscle cells (VSMCs), fibroblasts, and pericytes, concurrent with the activation of several signaling pathways, calcium, Wnt, BMP/Smad, and Notch, and the regulation by different molecular mediators, growth factors (GFs), osteogenic factors and matrix vesicles (MVs). In the present review, we aim to explore the cellular players, molecular pathways, biomarkers, and clinical treatment strategies associated with vascular calcification to provide a current and comprehensive overview of the topic.MDPIAlaimo, AlessandroUniversidad Complutense de Madrid20242024-02-2620242024-02-26journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/107111reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII) PI21%2F01244 INSUFICIENCIA PLACENTARIA SECUNDARIA A HIPERTENSION VENOSA GESTACIONAL: INFLUENCIA DEL ESTADO INFLAMATORIOopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1071112026-06-02T12:44:21Z
dc.title.none.fl_str_mv Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
title Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
spellingShingle Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
Ortega, Miguel A.
611.018
vascular calcification
signaling pathways
endothelial cells (ECs)
vascular smooth muscle cells (VSMCs)
biomarkers
Ciencias Biomédicas
32 Ciencias Médicas
title_short Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
title_full Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
title_fullStr Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
title_full_unstemmed Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
title_sort Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities
dc.creator.none.fl_str_mv Ortega, Miguel A.
Gimeno Longas, María José
Saez, Miguel A.
author Ortega, Miguel A.
author_facet Ortega, Miguel A.
Gimeno Longas, María José
Saez, Miguel A.
author_role author
author2 Gimeno Longas, María José
Saez, Miguel A.
author2_role author
author
dc.contributor.none.fl_str_mv Alaimo, Alessandro
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.018
vascular calcification
signaling pathways
endothelial cells (ECs)
vascular smooth muscle cells (VSMCs)
biomarkers
Ciencias Biomédicas
32 Ciencias Médicas
topic 611.018
vascular calcification
signaling pathways
endothelial cells (ECs)
vascular smooth muscle cells (VSMCs)
biomarkers
Ciencias Biomédicas
32 Ciencias Médicas
description Calcification is a process of accumulation of calcium in tissues and deposition of calcium salts by the crystallization of PO43− and ionized calcium (Ca2+). It is a crucial process in the development of bones and teeth. However, pathological calcification can occur in almost any soft tissue of the organism. The better studied is vascular calcification, where calcium salts can accumulate in the intima or medial layer or in aortic valves, and it is associated with higher mortality and cardiovascular events, including myocardial infarction, stroke, aortic and peripheral artery disease (PAD), and diabetes or chronic kidney disease (CKD), among others. The process involves an intricate interplay of different cellular components, endothelial cells (ECs), vascular smooth muscle cells (VSMCs), fibroblasts, and pericytes, concurrent with the activation of several signaling pathways, calcium, Wnt, BMP/Smad, and Notch, and the regulation by different molecular mediators, growth factors (GFs), osteogenic factors and matrix vesicles (MVs). In the present review, we aim to explore the cellular players, molecular pathways, biomarkers, and clinical treatment strategies associated with vascular calcification to provide a current and comprehensive overview of the topic.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-02-26
2024
2024-02-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/107111
url https://hdl.handle.net/20.500.14352/107111
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII) PI21%2F01244 INSUFICIENCIA PLACENTARIA SECUNDARIA A HIPERTENSION VENOSA GESTACIONAL: INFLUENCIA DEL ESTADO INFLAMATORIO
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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