Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.

Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiat...

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Autores: García-Marchena, Nuria, Marcos, Alberto, Flores-López, María, Moreno-Fernández, Mario, Requena-Ocaña, Nerea, Porras-Perales, Oscar, Torres-Galván, Sandra, Araos, Pedro, Serrano, Antonia, Muga, Roberto, Ruiz-Ruiz, Juan Jesús, Rodríguez de Fonseca, Fernando, Ambrosio, Emilio, Pavón-Morón, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18648
Acceso en línea:http://hdl.handle.net/20.500.12105/18648
Access Level:acceso abierto
Palabra clave:CE-LIF
PRISM
abstinence
alcohol use disorder
amino acids
biomarker
cocaine use disorder
cross-sectional study
psychiatric comorbidity
sex
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/18648
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repository_id_str
spelling Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.García-Marchena, NuriaMarcos, AlbertoFlores-López, MaríaMoreno-Fernández, MarioRequena-Ocaña, NereaPorras-Perales, OscarTorres-Galván, SandraAraos, PedroSerrano, AntoniaMuga, RobertoRuiz-Ruiz, Juan JesúsRodríguez de Fonseca, FernandoAmbrosio, EmilioPavón-Morón, Francisco JavierCE-LIFPRISMabstinencealcohol use disorderamino acidsbiomarkercocaine use disordercross-sectional studypsychiatric comorbiditysexBackground: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD.20242024-02-2720222022-05-1420222022-05-14research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18648reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/186482026-06-12T12:43:37Z
dc.title.none.fl_str_mv Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
title Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
spellingShingle Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
García-Marchena, Nuria
CE-LIF
PRISM
abstinence
alcohol use disorder
amino acids
biomarker
cocaine use disorder
cross-sectional study
psychiatric comorbidity
sex
title_short Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
title_full Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
title_fullStr Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
title_full_unstemmed Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
title_sort Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
dc.creator.none.fl_str_mv García-Marchena, Nuria
Marcos, Alberto
Flores-López, María
Moreno-Fernández, Mario
Requena-Ocaña, Nerea
Porras-Perales, Oscar
Torres-Galván, Sandra
Araos, Pedro
Serrano, Antonia
Muga, Roberto
Ruiz-Ruiz, Juan Jesús
Rodríguez de Fonseca, Fernando
Ambrosio, Emilio
Pavón-Morón, Francisco Javier
author García-Marchena, Nuria
author_facet García-Marchena, Nuria
Marcos, Alberto
Flores-López, María
Moreno-Fernández, Mario
Requena-Ocaña, Nerea
Porras-Perales, Oscar
Torres-Galván, Sandra
Araos, Pedro
Serrano, Antonia
Muga, Roberto
Ruiz-Ruiz, Juan Jesús
Rodríguez de Fonseca, Fernando
Ambrosio, Emilio
Pavón-Morón, Francisco Javier
author_role author
author2 Marcos, Alberto
Flores-López, María
Moreno-Fernández, Mario
Requena-Ocaña, Nerea
Porras-Perales, Oscar
Torres-Galván, Sandra
Araos, Pedro
Serrano, Antonia
Muga, Roberto
Ruiz-Ruiz, Juan Jesús
Rodríguez de Fonseca, Fernando
Ambrosio, Emilio
Pavón-Morón, Francisco Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv CE-LIF
PRISM
abstinence
alcohol use disorder
amino acids
biomarker
cocaine use disorder
cross-sectional study
psychiatric comorbidity
sex
topic CE-LIF
PRISM
abstinence
alcohol use disorder
amino acids
biomarker
cocaine use disorder
cross-sectional study
psychiatric comorbidity
sex
description Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-05-14
2022
2022-05-14
2024
2024-02-27
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18648
url http://hdl.handle.net/20.500.12105/18648
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410222566539264
score 15,811543

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