Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats

Background: Recent preclinical studies have shown sex-dependent antidepressant-like responses of cannabidiol in adolescence, which were dependent on biological sex, early-life stress, and dose. In particular, cannabidiol (10 mg/kg) induced acute and sustained antidepressant-like responses in adolesc...

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Autores: Gálvez-Melero, Laura, Beruete-Fresnillo, Itziar, Ledesma-Corvi, Sandra, García-Fuster, M Julia
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/25183
Acesso em linha:https://hdl.handle.net/20.500.13003/25183
Access Level:acceso abierto
Palavra-chave:Antidepressive Agents
Sex
Cannabidiol
Hippocampus
Neuroplasticity
Antidepresivos
Sexo
Hipocampo
Adolescence
Antidepressant
Biological sex
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spelling Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in ratsGálvez-Melero, LauraBeruete-Fresnillo, ItziarLedesma-Corvi, SandraGarcía-Fuster, M JuliaAntidepressive AgentsSexCannabidiolHippocampusNeuroplasticityAntidepresivosSexoCannabidiolHipocampoAdolescenceAntidepressantBiological sexCannabidiolHippocampusNeuroplasticityBackground: Recent preclinical studies have shown sex-dependent antidepressant-like responses of cannabidiol in adolescence, which were dependent on biological sex, early-life stress, and dose. In particular, cannabidiol (10 mg/kg) induced acute and sustained antidepressant-like responses in adolescent male rats, while it lacked efficacy in females. This follow-up study aimed at further characterizing cannabidiol's effects in adolescence, in an attempt to overcome female unresponsiveness, while also evaluating its long-term safety profile in adulthood. Methods: Groups of adolescent rats of both sexes were treated (ip) with cannabidiol (10, 30, 60 mg/kg) or vehicle (1 ml/kg) for 7 days. Acute (30 min post-injection) and repeated (24 h post-treatment) antidepressant-like responses were measured in the forced-swim test. Brains were collected to evaluate several neurochemical correlates in the hippocampus (CBR1, CBR2, BDNF, and cell proliferation) after adolescent cannabidiol exposure (acute and repeated). Some rats were left undisturbed until adulthood, when long-term effects on cognition were measured in the Barnes maze (short- and long-term memory) or affective-like responses in the forced-swim test. Data was analyzed with two-way ANOVAs (independent variables: sex and treatment). Results: While the dose of 10 mg/kg of cannabidiol induced antidepressant-like effects in adolescent rats, higher doses had no effect in adolescent rats of both sexes. No changes were observed in any of the hippocampal neuroplasticity markers evaluated. Adolescent cannabidiol exposure did not induce long-term changes in cognitive performance or affective-like behavior. Conclusions: Overall, our data suggest that adolescent cannabidiol treatment produces dose-dependent antidepressant-like effects of moderate magnitude without compromising long-term cognition in rats.Springer Nature Link20252025-01-0120252025-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/25183reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/251832026-06-22T12:44:07Z
dc.title.none.fl_str_mv Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
title Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
spellingShingle Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
Gálvez-Melero, Laura
Antidepressive Agents
Sex
Cannabidiol
Hippocampus
Neuroplasticity
Antidepresivos
Sexo
Cannabidiol
Hipocampo
Adolescence
Antidepressant
Biological sex
Cannabidiol
Hippocampus
Neuroplasticity
title_short Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
title_full Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
title_fullStr Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
title_full_unstemmed Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
title_sort Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
dc.creator.none.fl_str_mv Gálvez-Melero, Laura
Beruete-Fresnillo, Itziar
Ledesma-Corvi, Sandra
García-Fuster, M Julia
author Gálvez-Melero, Laura
author_facet Gálvez-Melero, Laura
Beruete-Fresnillo, Itziar
Ledesma-Corvi, Sandra
García-Fuster, M Julia
author_role author
author2 Beruete-Fresnillo, Itziar
Ledesma-Corvi, Sandra
García-Fuster, M Julia
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Antidepressive Agents
Sex
Cannabidiol
Hippocampus
Neuroplasticity
Antidepresivos
Sexo
Cannabidiol
Hipocampo
Adolescence
Antidepressant
Biological sex
Cannabidiol
Hippocampus
Neuroplasticity
topic Antidepressive Agents
Sex
Cannabidiol
Hippocampus
Neuroplasticity
Antidepresivos
Sexo
Cannabidiol
Hipocampo
Adolescence
Antidepressant
Biological sex
Cannabidiol
Hippocampus
Neuroplasticity
description Background: Recent preclinical studies have shown sex-dependent antidepressant-like responses of cannabidiol in adolescence, which were dependent on biological sex, early-life stress, and dose. In particular, cannabidiol (10 mg/kg) induced acute and sustained antidepressant-like responses in adolescent male rats, while it lacked efficacy in females. This follow-up study aimed at further characterizing cannabidiol's effects in adolescence, in an attempt to overcome female unresponsiveness, while also evaluating its long-term safety profile in adulthood. Methods: Groups of adolescent rats of both sexes were treated (ip) with cannabidiol (10, 30, 60 mg/kg) or vehicle (1 ml/kg) for 7 days. Acute (30 min post-injection) and repeated (24 h post-treatment) antidepressant-like responses were measured in the forced-swim test. Brains were collected to evaluate several neurochemical correlates in the hippocampus (CBR1, CBR2, BDNF, and cell proliferation) after adolescent cannabidiol exposure (acute and repeated). Some rats were left undisturbed until adulthood, when long-term effects on cognition were measured in the Barnes maze (short- and long-term memory) or affective-like responses in the forced-swim test. Data was analyzed with two-way ANOVAs (independent variables: sex and treatment). Results: While the dose of 10 mg/kg of cannabidiol induced antidepressant-like effects in adolescent rats, higher doses had no effect in adolescent rats of both sexes. No changes were observed in any of the hippocampal neuroplasticity markers evaluated. Adolescent cannabidiol exposure did not induce long-term changes in cognitive performance or affective-like behavior. Conclusions: Overall, our data suggest that adolescent cannabidiol treatment produces dose-dependent antidepressant-like effects of moderate magnitude without compromising long-term cognition in rats.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/25183
url https://hdl.handle.net/20.500.13003/25183
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature Link
publisher.none.fl_str_mv Springer Nature Link
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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