Bovine infectious abortion: a systematic review and meta-analysis

The aim of the present systematic review and meta-analysis was to identify the main infectious agents related to bovine abortion worldwide in the period between 2000 and 2022. First, we investigated the global prevalence of infectious agents related to bovine abortion. For this analysis, only 27 art...

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Authors: Hecker, Yanina Paola, González Ortega, Sara, Cano, Santiago, Ortega Mora, Luis Miguel, Horcajo Iglesias, María Del Pilar
Format: article
Publication Date:2023
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/104414
Online Access:https://hdl.handle.net/20.500.14352/104414
Access Level:Open access
Keyword:636.09
Bovine abortion
Infectious agents
Prevalence
Diagnosis
Meta-analysis
Veterinaria
3109 Ciencias Veterinarias
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spelling Bovine infectious abortion: a systematic review and meta-analysisHecker, Yanina PaolaGonzález Ortega, SaraCano, SantiagoOrtega Mora, Luis MiguelHorcajo Iglesias, María Del Pilar636.09Bovine abortionInfectious agentsPrevalenceDiagnosisMeta-analysisVeterinaria3109 Ciencias VeterinariasThe aim of the present systematic review and meta-analysis was to identify the main infectious agents related to bovine abortion worldwide in the period between 2000 and 2022. First, we investigated the global prevalence of infectious agents related to bovine abortion. For this analysis, only 27 articles detected of a wide panel of agents were included. The random effects model revealed that the estimated prevalence of the abortifacient agents in bovine abortion was 45.7%. The heterogeneity among studies was high, but Egger’s test showed that there was no publication bias, even though the total number of samples analyzed in these articles was variable. There was no significant effect of the year of the study publication on the estimated prevalence, although an increasing trend was observed over time, possibly due to the implementation of new diagnostic techniques. Then, we analyzed the prevalence of the main transmissible agents in bovine abortion. For this analysis, 76 studies that analyzed 19,070 cases were included. Some infectious agent was detected in 7,319 specimens, and a final diagnosis was reached in 3,977 of these, when both the infectious agent and compatible histopathological changes were detected. We found that Neospora caninum was the most detected agent (22.2%), followed by opportunistic bacteria (21.4%), Chlamydiaceae family (10.9%) and Coxiella burnetii (9.5%). Regarding viral agents, bovine herpes virus type 1 and bovine viral diarrhea displayed similar prevalence rates (approximately 5%). After considering the description of specific histopathological changes, our analyzes showed that N. caninum was a confirmed cause of abortion in 16.7% of the analyzed cases, followed by opportunistic bacteria (12.6%) and Chlamydia spp. (6.8%); however, C. burnetii was only confirmed as a cause of abortion in 1.1% of the cases. For all agents, the heterogeneity among studies was high, and the subgroup analyzes discarded the diagnostic method as the cause of such heterogeneity. This study provides knowledge about the global prevalence of the different infectious agents related to bovine abortion, the most coming of which is N. caninum. In addition, this review reveals the existing deficiencies in the diagnosis of bovine abortion that must be addressed in the future.FrontiersUniversidad Complutense de Madrid20232023-09-2920232023-09-29journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104414reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104713RB-C21 ESTUDIO DE LA INTERACCION ENTRE LOS FACTORES DE VIRULENCIA DEL PARASITO Y LA RESPUESTA INMUNE INNATA EN LA NEOSPOROSIS BOVINAopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1044142026-06-02T12:44:21Z
dc.title.none.fl_str_mv Bovine infectious abortion: a systematic review and meta-analysis
title Bovine infectious abortion: a systematic review and meta-analysis
spellingShingle Bovine infectious abortion: a systematic review and meta-analysis
Hecker, Yanina Paola
636.09
Bovine abortion
Infectious agents
Prevalence
Diagnosis
Meta-analysis
Veterinaria
3109 Ciencias Veterinarias
title_short Bovine infectious abortion: a systematic review and meta-analysis
title_full Bovine infectious abortion: a systematic review and meta-analysis
title_fullStr Bovine infectious abortion: a systematic review and meta-analysis
title_full_unstemmed Bovine infectious abortion: a systematic review and meta-analysis
title_sort Bovine infectious abortion: a systematic review and meta-analysis
dc.creator.none.fl_str_mv Hecker, Yanina Paola
González Ortega, Sara
Cano, Santiago
Ortega Mora, Luis Miguel
Horcajo Iglesias, María Del Pilar
author Hecker, Yanina Paola
author_facet Hecker, Yanina Paola
González Ortega, Sara
Cano, Santiago
Ortega Mora, Luis Miguel
Horcajo Iglesias, María Del Pilar
author_role author
author2 González Ortega, Sara
Cano, Santiago
Ortega Mora, Luis Miguel
Horcajo Iglesias, María Del Pilar
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09
Bovine abortion
Infectious agents
Prevalence
Diagnosis
Meta-analysis
Veterinaria
3109 Ciencias Veterinarias
topic 636.09
Bovine abortion
Infectious agents
Prevalence
Diagnosis
Meta-analysis
Veterinaria
3109 Ciencias Veterinarias
description The aim of the present systematic review and meta-analysis was to identify the main infectious agents related to bovine abortion worldwide in the period between 2000 and 2022. First, we investigated the global prevalence of infectious agents related to bovine abortion. For this analysis, only 27 articles detected of a wide panel of agents were included. The random effects model revealed that the estimated prevalence of the abortifacient agents in bovine abortion was 45.7%. The heterogeneity among studies was high, but Egger’s test showed that there was no publication bias, even though the total number of samples analyzed in these articles was variable. There was no significant effect of the year of the study publication on the estimated prevalence, although an increasing trend was observed over time, possibly due to the implementation of new diagnostic techniques. Then, we analyzed the prevalence of the main transmissible agents in bovine abortion. For this analysis, 76 studies that analyzed 19,070 cases were included. Some infectious agent was detected in 7,319 specimens, and a final diagnosis was reached in 3,977 of these, when both the infectious agent and compatible histopathological changes were detected. We found that Neospora caninum was the most detected agent (22.2%), followed by opportunistic bacteria (21.4%), Chlamydiaceae family (10.9%) and Coxiella burnetii (9.5%). Regarding viral agents, bovine herpes virus type 1 and bovine viral diarrhea displayed similar prevalence rates (approximately 5%). After considering the description of specific histopathological changes, our analyzes showed that N. caninum was a confirmed cause of abortion in 16.7% of the analyzed cases, followed by opportunistic bacteria (12.6%) and Chlamydia spp. (6.8%); however, C. burnetii was only confirmed as a cause of abortion in 1.1% of the cases. For all agents, the heterogeneity among studies was high, and the subgroup analyzes discarded the diagnostic method as the cause of such heterogeneity. This study provides knowledge about the global prevalence of the different infectious agents related to bovine abortion, the most coming of which is N. caninum. In addition, this review reveals the existing deficiencies in the diagnosis of bovine abortion that must be addressed in the future.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-09-29
2023
2023-09-29
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104414
url https://hdl.handle.net/20.500.14352/104414
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104713RB-C21 ESTUDIO DE LA INTERACCION ENTRE LOS FACTORES DE VIRULENCIA DEL PARASITO Y LA RESPUESTA INMUNE INNATA EN LA NEOSPOROSIS BOVINA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
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