Fungal Ribotoxins

Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent because ribotoxins cleave one single phosphodiester bo...

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Detalles Bibliográficos
Autores: García Ortega, Lucía, Palacios Ortega, Juan, Martínez Del Pozo, Álvaro
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/11971
Acceso en línea:https://hdl.handle.net/20.500.14352/11971
Access Level:acceso abierto
Palabra clave:577.1
antitumoural
elongation factor
entomopathogen
fungal toxin
immunotoxin
insecticide
ribonuclease
ribosome
ribotoxin
sarcin
Biología molecular (Química)
Bioquímica (Química)
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spelling Fungal RibotoxinsGarcía Ortega, LucíaPalacios Ortega, JuanMartínez Del Pozo, Álvaro577.1antitumouralelongation factorentomopathogenfungal toxinimmunotoxininsecticideribonucleaseribosomeribotoxinsarcinBiología molecular (Química)Bioquímica (Química)Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent because ribotoxins cleave one single phosphodiester bond, located at a unique and universally conserved loop, needed for elongation factors function. As secreted proteins, ribotoxins need to cross the membrane of their target cells in order to exert their catalytic activity, and they do it without receptor mediation. Using lipid model systems, it has been shown that they are able to enter cells with membranes enriched in acidic phospholipids. Both membrane-interacting and ribosomal-recognition activities are characterised by distinct structural features. Even though the natural function of ribotoxins is not known yet, their production by entomopathogenic fungi has suggested their insecticidal role. After decades of detailed study, the biotechnological potential of ribotoxins in pest control and as antitumour agents is becoming evident.Wiley Online LibraryUniversidad Complutense de Madrid20182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/11971reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/119712026-06-02T12:44:21Z
dc.title.none.fl_str_mv Fungal Ribotoxins
title Fungal Ribotoxins
spellingShingle Fungal Ribotoxins
García Ortega, Lucía
577.1
antitumoural
elongation factor
entomopathogen
fungal toxin
immunotoxin
insecticide
ribonuclease
ribosome
ribotoxin
sarcin
Biología molecular (Química)
Bioquímica (Química)
title_short Fungal Ribotoxins
title_full Fungal Ribotoxins
title_fullStr Fungal Ribotoxins
title_full_unstemmed Fungal Ribotoxins
title_sort Fungal Ribotoxins
dc.creator.none.fl_str_mv García Ortega, Lucía
Palacios Ortega, Juan
Martínez Del Pozo, Álvaro
author García Ortega, Lucía
author_facet García Ortega, Lucía
Palacios Ortega, Juan
Martínez Del Pozo, Álvaro
author_role author
author2 Palacios Ortega, Juan
Martínez Del Pozo, Álvaro
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.1
antitumoural
elongation factor
entomopathogen
fungal toxin
immunotoxin
insecticide
ribonuclease
ribosome
ribotoxin
sarcin
Biología molecular (Química)
Bioquímica (Química)
topic 577.1
antitumoural
elongation factor
entomopathogen
fungal toxin
immunotoxin
insecticide
ribonuclease
ribosome
ribotoxin
sarcin
Biología molecular (Química)
Bioquímica (Química)
description Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent because ribotoxins cleave one single phosphodiester bond, located at a unique and universally conserved loop, needed for elongation factors function. As secreted proteins, ribotoxins need to cross the membrane of their target cells in order to exert their catalytic activity, and they do it without receptor mediation. Using lipid model systems, it has been shown that they are able to enter cells with membranes enriched in acidic phospholipids. Both membrane-interacting and ribosomal-recognition activities are characterised by distinct structural features. Even though the natural function of ribotoxins is not known yet, their production by entomopathogenic fungi has suggested their insecticidal role. After decades of detailed study, the biotechnological potential of ribotoxins in pest control and as antitumour agents is becoming evident.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/11971
url https://hdl.handle.net/20.500.14352/11971
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410197479358464
score 15.300724

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