New and Old Key Players in Liver Cancer

Liver cancer represents a major health problem worldwide with growing incidence and high mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely the cellular origin of most HCCs through the accumulation of genetic alterations, although hepatic progenitor cells (HPCs...

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Autores: Cuesta Martínez, Ángel, Palao, Nerea, Bragado Domingo, Paloma, Gutiérrez Uzquiza, Álvaro, Herrera González, Blanca María, Sánchez Muñoz, Aranzazu, Porras Gallo, María Almudena
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/105544
Acceso en línea:https://hdl.handle.net/20.500.14352/105544
Access Level:acceso abierto
Palabra clave:577.1
577.2
Liver cancer
C3G/RAPGEF1
platelets
tumor microenvironment
TGF-β
EGFR
MET
HGF
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
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spelling New and Old Key Players in Liver CancerCuesta Martínez, ÁngelPalao, NereaBragado Domingo, PalomaGutiérrez Uzquiza, ÁlvaroHerrera González, Blanca MaríaSánchez Muñoz, AranzazuPorras Gallo, María Almudena577.1577.2Liver cancerC3G/RAPGEF1plateletstumor microenvironmentTGF-βEGFRMETHGFBiología molecular (Farmacia)Bioquímica (Farmacia)32 Ciencias MédicasLiver cancer represents a major health problem worldwide with growing incidence and high mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely the cellular origin of most HCCs through the accumulation of genetic alterations, although hepatic progenitor cells (HPCs) might also be candidates in specific cases, as discussed here. HCC usually develops in a context of chronic inflammation, fibrosis, and cirrhosis, although the role of fibrosis is controversial. The interplay between hepatocytes, immune cells and hepatic stellate cells is a key issue. This review summarizes critical aspects of the liver tumor microenvironment paying special attention to platelets as new key players, which exert both pro- and anti-tumor effects, determined by specific contexts and a tight regulation of platelet signaling. Additionally, the relevance of specific signaling pathways, mainly HGF/MET, EGFR and TGF-β is discussed. HGF and TGF-β are produced by different liver cells and platelets and regulate not only tumor cell fate but also HPCs, inflammation and fibrosis, these being key players in these processes. The role of C3G/RAPGEF1, required for the proper function of HGF/MET signaling in HCC and HPCs, is highlighted, due to its ability to promote HCC growth and, regulate HPC fate and platelet-mediated actions on liver cancer.MDPIUniversidad Complutense de Madrid20232023-12-0520232023-12-05journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/105544reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124830OB-I0Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-117650RA-I00 USO DE LA TECNOLOGIA CRISPR%2FCAS9 PARA LA IDENTIFICACION DE NUEVOS MARCADORES METASTASICOS EN CANCER DE PROSTATAAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104991RB-I00 DESCIFRANDO LA FUNCION DE LAS NEUROPILINAS Y LAS PLEXINAS EN LA REGULACION DEL DESTINO CELULAR DE LAS CELULAS TUMORALES DISEMINADAS Y LA FORMACION DE METASTASISAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104143RB-C22 NUEVAS FUNCIONES DE C3G EN LA PROGRESION TUMORAL Y FISIOLOGIA DEL HIGADO. IMPLICACION DE C3G PLAQUETARIA EN LA RESPUESTA AL DAÑO HEPATICOAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-137717OB-C21open accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1055442026-06-02T12:44:21Z
dc.title.none.fl_str_mv New and Old Key Players in Liver Cancer
title New and Old Key Players in Liver Cancer
spellingShingle New and Old Key Players in Liver Cancer
Cuesta Martínez, Ángel
577.1
577.2
Liver cancer
C3G/RAPGEF1
platelets
tumor microenvironment
TGF-β
EGFR
MET
HGF
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
title_short New and Old Key Players in Liver Cancer
title_full New and Old Key Players in Liver Cancer
title_fullStr New and Old Key Players in Liver Cancer
title_full_unstemmed New and Old Key Players in Liver Cancer
title_sort New and Old Key Players in Liver Cancer
dc.creator.none.fl_str_mv Cuesta Martínez, Ángel
Palao, Nerea
Bragado Domingo, Paloma
Gutiérrez Uzquiza, Álvaro
Herrera González, Blanca María
Sánchez Muñoz, Aranzazu
Porras Gallo, María Almudena
author Cuesta Martínez, Ángel
author_facet Cuesta Martínez, Ángel
Palao, Nerea
Bragado Domingo, Paloma
Gutiérrez Uzquiza, Álvaro
Herrera González, Blanca María
Sánchez Muñoz, Aranzazu
Porras Gallo, María Almudena
author_role author
author2 Palao, Nerea
Bragado Domingo, Paloma
Gutiérrez Uzquiza, Álvaro
Herrera González, Blanca María
Sánchez Muñoz, Aranzazu
Porras Gallo, María Almudena
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.1
577.2
Liver cancer
C3G/RAPGEF1
platelets
tumor microenvironment
TGF-β
EGFR
MET
HGF
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
topic 577.1
577.2
Liver cancer
C3G/RAPGEF1
platelets
tumor microenvironment
TGF-β
EGFR
MET
HGF
Biología molecular (Farmacia)
Bioquímica (Farmacia)
32 Ciencias Médicas
description Liver cancer represents a major health problem worldwide with growing incidence and high mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely the cellular origin of most HCCs through the accumulation of genetic alterations, although hepatic progenitor cells (HPCs) might also be candidates in specific cases, as discussed here. HCC usually develops in a context of chronic inflammation, fibrosis, and cirrhosis, although the role of fibrosis is controversial. The interplay between hepatocytes, immune cells and hepatic stellate cells is a key issue. This review summarizes critical aspects of the liver tumor microenvironment paying special attention to platelets as new key players, which exert both pro- and anti-tumor effects, determined by specific contexts and a tight regulation of platelet signaling. Additionally, the relevance of specific signaling pathways, mainly HGF/MET, EGFR and TGF-β is discussed. HGF and TGF-β are produced by different liver cells and platelets and regulate not only tumor cell fate but also HPCs, inflammation and fibrosis, these being key players in these processes. The role of C3G/RAPGEF1, required for the proper function of HGF/MET signaling in HCC and HPCs, is highlighted, due to its ability to promote HCC growth and, regulate HPC fate and platelet-mediated actions on liver cancer.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-12-05
2023
2023-12-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/105544
url https://hdl.handle.net/20.500.14352/105544
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124830OB-I0
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-117650RA-I00 USO DE LA TECNOLOGIA CRISPR%2FCAS9 PARA LA IDENTIFICACION DE NUEVOS MARCADORES METASTASICOS EN CANCER DE PROSTATA
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104991RB-I00 DESCIFRANDO LA FUNCION DE LAS NEUROPILINAS Y LAS PLEXINAS EN LA REGULACION DEL DESTINO CELULAR DE LAS CELULAS TUMORALES DISEMINADAS Y LA FORMACION DE METASTASIS
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104143RB-C22 NUEVAS FUNCIONES DE C3G EN LA PROGRESION TUMORAL Y FISIOLOGIA DEL HIGADO. IMPLICACION DE C3G PLAQUETARIA EN LA RESPUESTA AL DAÑO HEPATICO
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-137717OB-C21
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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