Contribution of obesity associated genetic variants to anthropometric somatotype components

The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample...

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Autores: Ibáñez Pérez-Zamacona, María Eugenia, Poveda Zabala, Alaitz, Rebato Ochoa, Esther Matilde
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/74683
Acceso en línea:http://hdl.handle.net/10810/74683
Access Level:acceso abierto
Palabra clave:anthropometric somatotype
BMI
obesity
genetic variants
SNPs
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spelling Contribution of obesity associated genetic variants to anthropometric somatotype componentsIbáñez Pérez-Zamacona, María EugeniaPoveda Zabala, AlaitzRebato Ochoa, Esther Matildeanthropometric somatotypeBMIobesitygenetic variantsSNPsThe somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 years old. A literature search was conducted in PubMed to select genetic variants associated with obesity in European derived populations. After the quality control of the chosen variants, 21 SNPs were finally used to conduct association analyses. Logistic and linear regressions implemented in PLINK (v1.07) were used to assess the association between SNPs and the somatotype. Two genetic variants (rs925946 in BDNF and rs10146997 in NRXN3) showed a significant association with endomorphy (p < 0.01) while rs10146997 (in NRXN3) and rs9939609 (in FTO) were associated with mesomorphy (p < 0.01). rs925946 (in BDNF), rs10146997 (in NRXN3), rs9939609 (in FTO) and rs4776970 (in MAP2K5) were associated with ectomorphy (p < 0.05). In conclusion, four genetic variants (in or near BDNF, NRXN3, MAP2K5 and FTO) contribute to body shape and composition in the analysed sample.Schweizerbart Science Publishers202520252019info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/74683reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://doi.org/10.1127/anthranz/2019/0945info:eu-repo/semantics/openAccess© 2019 E. Schweizerbart Science Publishersoai:addi.ehu.eus:10810/746832026-06-18T09:23:17Z
dc.title.none.fl_str_mv Contribution of obesity associated genetic variants to anthropometric somatotype components
title Contribution of obesity associated genetic variants to anthropometric somatotype components
spellingShingle Contribution of obesity associated genetic variants to anthropometric somatotype components
Ibáñez Pérez-Zamacona, María Eugenia
anthropometric somatotype
BMI
obesity
genetic variants
SNPs
title_short Contribution of obesity associated genetic variants to anthropometric somatotype components
title_full Contribution of obesity associated genetic variants to anthropometric somatotype components
title_fullStr Contribution of obesity associated genetic variants to anthropometric somatotype components
title_full_unstemmed Contribution of obesity associated genetic variants to anthropometric somatotype components
title_sort Contribution of obesity associated genetic variants to anthropometric somatotype components
dc.creator.none.fl_str_mv Ibáñez Pérez-Zamacona, María Eugenia
Poveda Zabala, Alaitz
Rebato Ochoa, Esther Matilde
author Ibáñez Pérez-Zamacona, María Eugenia
author_facet Ibáñez Pérez-Zamacona, María Eugenia
Poveda Zabala, Alaitz
Rebato Ochoa, Esther Matilde
author_role author
author2 Poveda Zabala, Alaitz
Rebato Ochoa, Esther Matilde
author2_role author
author
dc.subject.none.fl_str_mv anthropometric somatotype
BMI
obesity
genetic variants
SNPs
topic anthropometric somatotype
BMI
obesity
genetic variants
SNPs
description The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 years old. A literature search was conducted in PubMed to select genetic variants associated with obesity in European derived populations. After the quality control of the chosen variants, 21 SNPs were finally used to conduct association analyses. Logistic and linear regressions implemented in PLINK (v1.07) were used to assess the association between SNPs and the somatotype. Two genetic variants (rs925946 in BDNF and rs10146997 in NRXN3) showed a significant association with endomorphy (p < 0.01) while rs10146997 (in NRXN3) and rs9939609 (in FTO) were associated with mesomorphy (p < 0.01). rs925946 (in BDNF), rs10146997 (in NRXN3), rs9939609 (in FTO) and rs4776970 (in MAP2K5) were associated with ectomorphy (p < 0.05). In conclusion, four genetic variants (in or near BDNF, NRXN3, MAP2K5 and FTO) contribute to body shape and composition in the analysed sample.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/74683
url http://hdl.handle.net/10810/74683
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1127/anthranz/2019/0945
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
© 2019 E. Schweizerbart Science Publishers
eu_rights_str_mv openAccess
rights_invalid_str_mv © 2019 E. Schweizerbart Science Publishers
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Schweizerbart Science Publishers
publisher.none.fl_str_mv Schweizerbart Science Publishers
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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