Primary hypothyroidism in a child leads to pituitary hyperplasia

A sellar mass in children is most often seen in craniopharyngeal tumors, intracranial germ cell tumors, or pituitary adenomas. However, pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is not commonly seen in children. A 10-year-old girl was admitted due to growth retardation and obe...

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Autores: Cao, Junguo, Lei, Ting|||0000-0002-2787-5208, Chen, Fan, Zhang, Chaochao, Ma, Chengyuan, Huang, Haiyan
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253682
Acceso en línea:https://ddd.uab.cat/record/253682
https://dx.doi.org/urn:doi:10.1097/MD.0000000000012703
Access Level:acceso abierto
Palabra clave:Pituitary adenoma
Pituitary hyperplasia
Primary hypothyroidism
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spelling Primary hypothyroidism in a child leads to pituitary hyperplasiaCao, JunguoLei, Ting|||0000-0002-2787-5208Chen, FanZhang, ChaochaoMa, ChengyuanHuang, HaiyanPituitary adenomaPituitary hyperplasiaPrimary hypothyroidismA sellar mass in children is most often seen in craniopharyngeal tumors, intracranial germ cell tumors, or pituitary adenomas. However, pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is not commonly seen in children. A 10-year-old girl was admitted due to growth retardation and obesity for 4 years. On physical examination, the patient had a height of 118 cm, body weight of 46 kg, body mass index (BMI) of 33.0 kg/m 2. After magnetic resonance imaging (MRI) and laboratory tests, her initial diagnosis was Hashimoto's thyroiditis, primary hypothyroidism, and reactive pituitary hyperplasia. She was treated with oral L-thyroxine tablets. After 6 months, physical examination showed a height of 125 cm, weight of 36 kg, BMI of 23.0 kg/m 2. She developed well, with 12 cm of yearly growth thereafter. The diagnosis of PHPH in a child is very important and sometimes difficult. Based on the summary and analysis of previous cases, we can learn that the main manifestations of PHPH include growth arrest and obesity, perhaps accompanied by symptoms caused by a decreased thyroid hormone concentration and elevated prolactin (PRL) concentration. Intracranial MRI shows diffuse enlargement of the anterior lobe of the pituitary gland, with a dome-shaped blunt edge change. Thyroid hormone levels may decrease, whereas the thyroid stimulating hormone (TSH) level increases, commonly accompanied by an elevated PRL, reduced growth hormone (GH) levels, and positive findings of TPOAb and TGAb. Improvement of symptoms and the normalization of hormone levels as well as restoration of pituitary size can be achieved after treated with thyroid hormone replacement therapy. And a hasty decision on surgical resection should be avoided when the diagnosis is uncertain.Universitat Autònoma de Barcelona 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253682https://dx.doi.org/urn:doi:10.1097/MD.0000000000012703reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2536822026-06-06T12:50:31Z
dc.title.none.fl_str_mv Primary hypothyroidism in a child leads to pituitary hyperplasia
title Primary hypothyroidism in a child leads to pituitary hyperplasia
spellingShingle Primary hypothyroidism in a child leads to pituitary hyperplasia
Cao, Junguo
Pituitary adenoma
Pituitary hyperplasia
Primary hypothyroidism
title_short Primary hypothyroidism in a child leads to pituitary hyperplasia
title_full Primary hypothyroidism in a child leads to pituitary hyperplasia
title_fullStr Primary hypothyroidism in a child leads to pituitary hyperplasia
title_full_unstemmed Primary hypothyroidism in a child leads to pituitary hyperplasia
title_sort Primary hypothyroidism in a child leads to pituitary hyperplasia
dc.creator.none.fl_str_mv Cao, Junguo
Lei, Ting|||0000-0002-2787-5208
Chen, Fan
Zhang, Chaochao
Ma, Chengyuan
Huang, Haiyan
author Cao, Junguo
author_facet Cao, Junguo
Lei, Ting|||0000-0002-2787-5208
Chen, Fan
Zhang, Chaochao
Ma, Chengyuan
Huang, Haiyan
author_role author
author2 Lei, Ting|||0000-0002-2787-5208
Chen, Fan
Zhang, Chaochao
Ma, Chengyuan
Huang, Haiyan
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Pituitary adenoma
Pituitary hyperplasia
Primary hypothyroidism
topic Pituitary adenoma
Pituitary hyperplasia
Primary hypothyroidism
description A sellar mass in children is most often seen in craniopharyngeal tumors, intracranial germ cell tumors, or pituitary adenomas. However, pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is not commonly seen in children. A 10-year-old girl was admitted due to growth retardation and obesity for 4 years. On physical examination, the patient had a height of 118 cm, body weight of 46 kg, body mass index (BMI) of 33.0 kg/m 2. After magnetic resonance imaging (MRI) and laboratory tests, her initial diagnosis was Hashimoto's thyroiditis, primary hypothyroidism, and reactive pituitary hyperplasia. She was treated with oral L-thyroxine tablets. After 6 months, physical examination showed a height of 125 cm, weight of 36 kg, BMI of 23.0 kg/m 2. She developed well, with 12 cm of yearly growth thereafter. The diagnosis of PHPH in a child is very important and sometimes difficult. Based on the summary and analysis of previous cases, we can learn that the main manifestations of PHPH include growth arrest and obesity, perhaps accompanied by symptoms caused by a decreased thyroid hormone concentration and elevated prolactin (PRL) concentration. Intracranial MRI shows diffuse enlargement of the anterior lobe of the pituitary gland, with a dome-shaped blunt edge change. Thyroid hormone levels may decrease, whereas the thyroid stimulating hormone (TSH) level increases, commonly accompanied by an elevated PRL, reduced growth hormone (GH) levels, and positive findings of TPOAb and TGAb. Improvement of symptoms and the normalization of hormone levels as well as restoration of pituitary size can be achieved after treated with thyroid hormone replacement therapy. And a hasty decision on surgical resection should be avoided when the diagnosis is uncertain.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253682
https://dx.doi.org/urn:doi:10.1097/MD.0000000000012703
url https://ddd.uab.cat/record/253682
https://dx.doi.org/urn:doi:10.1097/MD.0000000000012703
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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