Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf

© 2020 by the authors.

Detalhes bibliográficos
Autores: Marchetta, Philine, Savitska, Daria, Kübler, Angelika, Asola, Giulia, Manthey, Marie, Möhrle, Dorit, Schimmang, Thomas, Rüttiger, Lukas, Knipper, Marlies, Singer, Wibke
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/226354
Acesso em linha:http://hdl.handle.net/10261/226354
Access Level:acceso abierto
Palavra-chave:Central compensation
Cochlear synaptopathy
Auditory nerve latency
Age-related hearing loss
Activity dependent BDNF
Long term potentiation
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spelling Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnfMarchetta, PhilineSavitska, DariaKübler, AngelikaAsola, GiuliaManthey, MarieMöhrle, DoritSchimmang, ThomasRüttiger, LukasKnipper, MarliesSinger, WibkeCentral compensationCochlear synaptopathyAuditory nerve latencyAge-related hearing lossActivity dependent BDNFLong term potentiation© 2020 by the authors.Age-related decoupling of auditory nerve fibers from hair cells (cochlear synaptopathy) has been linked to temporal processing deficits and impaired speech recognition performance. The link between both is elusive. We have previously demonstrated that cochlear synaptopathy, if centrally compensated through enhanced input/output function (neural gain), can prevent age-dependent temporal discrimination loss. It was also found that central neural gain after acoustic trauma was linked to hippocampal long-term potentiation (LTP) and upregulation of brain-derived neurotrophic factor (BDNF). Using middle-aged and old BDNF-live-exon-visualization (BLEV) reporter mice we analyzed the specific recruitment of LTP and the activity-dependent usage of Bdnf exon-IV and -VI promoters relative to cochlear synaptopathy and central (temporal) processing. For both groups, specimens with higher or lower ability to centrally compensate diminished auditory nerve activity were found. Strikingly, low compensating mouse groups differed from high compensators by prolonged auditory nerve latency. Moreover, low compensators exhibited attenuated responses to amplitude-modulated tones, and a reduction of hippocampal LTP and Bdnf transcript levels in comparison to high compensators. These results suggest that latency of auditory nerve processing, recruitment of hippocampal LTP, and Bdnf transcription, are key factors for age-dependent auditory processing deficits, rather than cochlear synaptopathy or aging per se.We acknowledge grants from the Deutsche Forschungsgemeinschaft FOR 2060 project RU 713/3-2 (W.S., L.R., D.M.), Projektnummer 335549539/GRK 2381 (P.M.), SPP 1608 RU 316/12-1 (L.R.), and KN 316/12-1 (M.M, M.K.), Siegmund Kiener Stiftung (D.S.) and BFU2016-76580-P (T.S).Multidisciplinary Digital Publishing InstituteGerman Research FoundationMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/226354reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-76580-Phttp://dx.doi.org/10.3390/brainsci10100710Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2263542026-05-22T06:33:51Z
dc.title.none.fl_str_mv Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
title Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
spellingShingle Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
Marchetta, Philine
Central compensation
Cochlear synaptopathy
Auditory nerve latency
Age-related hearing loss
Activity dependent BDNF
Long term potentiation
title_short Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
title_full Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
title_fullStr Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
title_full_unstemmed Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
title_sort Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit ltp/bdnf
dc.creator.none.fl_str_mv Marchetta, Philine
Savitska, Daria
Kübler, Angelika
Asola, Giulia
Manthey, Marie
Möhrle, Dorit
Schimmang, Thomas
Rüttiger, Lukas
Knipper, Marlies
Singer, Wibke
author Marchetta, Philine
author_facet Marchetta, Philine
Savitska, Daria
Kübler, Angelika
Asola, Giulia
Manthey, Marie
Möhrle, Dorit
Schimmang, Thomas
Rüttiger, Lukas
Knipper, Marlies
Singer, Wibke
author_role author
author2 Savitska, Daria
Kübler, Angelika
Asola, Giulia
Manthey, Marie
Möhrle, Dorit
Schimmang, Thomas
Rüttiger, Lukas
Knipper, Marlies
Singer, Wibke
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv German Research Foundation
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Central compensation
Cochlear synaptopathy
Auditory nerve latency
Age-related hearing loss
Activity dependent BDNF
Long term potentiation
topic Central compensation
Cochlear synaptopathy
Auditory nerve latency
Age-related hearing loss
Activity dependent BDNF
Long term potentiation
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/226354
url http://hdl.handle.net/10261/226354
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-76580-P
http://dx.doi.org/10.3390/brainsci10100710
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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