Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study

Background and Aims: Many addictive substances, such as tobacco and alcohol, influence atherosclerosis development. Whether or not tobacco's pro-atherosclerotic effect is influenced by alcohol consumption is unknown. We aimed to estimate the impact of alcohol intake on the presence of subclinic...

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Autores: Moreno-Franco, Belén, Pérez-Esteban, Alejandro, Civeira, Fernando, Guallar-Castillón, Pilar, Casasnovas, José Antonio, Mateo-Gállego, Rocío, Jarauta, Estíbaliz, Malo, Sara, Laclaustra, Martín
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:148091
Acceso en línea:http://zaguan.unizar.es/record/148091
Access Level:acceso abierto
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spelling Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS StudyMoreno-Franco, BelénPérez-Esteban, AlejandroCiveira, FernandoGuallar-Castillón, PilarCasasnovas, José AntonioMateo-Gállego, RocíoJarauta, EstíbalizMalo, SaraLaclaustra, MartínBackground and Aims: Many addictive substances, such as tobacco and alcohol, influence atherosclerosis development. Whether or not tobacco's pro-atherosclerotic effect is influenced by alcohol consumption is unknown. We aimed to estimate the impact of alcohol intake on the presence of subclinical atherosclerosis in femoral arteries in smoking and non-smoking middle-aged men.Design, Setting and Participants: Cross-sectional analysis of a subset of the Aragon Workers Health Study (AWHS), comprising 2099 men with mean age 50.9 years without previous cardiovascular disease. Measurements: The presence of plaques in femoral arteries was assessed by high-resolution sonography. Self-reported alcohol consumption over the previous year was measured with a food frequency questionnaire. The sample was divided into four groups according to their daily grams of alcohol consumption = 1 (abstainers), = 2 to < 30, = 30 to < 60 and = 60 g/day. Participants were divided on ever-smoking (current and former) versus never-smoking strata in the main analysis. Findings: We did not find a significant association between the different levels of alcohol intake and the likelihood of developing femoral artery atherosclerosis in never-smokers. Ever-smoking was positively associated with femoral atherosclerosis overall [odds ratio (OR) = 3.00; 95% confidence interval (CI) = 2.40, 3.74; P < 0.001] and within each level of alcohol consumption. Atherosclerosis was lower in ever-smokers who consumed 2 g/day or more but less than 30 g/day with respect to those ever-smokers who were abstainers (OR = 0.70; 95% CI = 0.49, 0.99; P < 0.05). However, among these ever-smokers, atherosclerosis prevalence was still higher than among never-smokers who consumed alcohol in the same amount (2 g/day or more but less than 30 g/day) (OR = 2.73; 95% CI = 2.07, 3.61; P < 0.001). Conclusions: Among middle-aged men, moderate alcohol consumption appears to be associated with lower prevalence of femoral artery subclinical atherosclerosis compared with alcohol abstinence only in ever-smokers.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://zaguan.unizar.es/record/148091reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/ISCIII/FISinfo:eu-repo/grantAgreement/ES/ISCIII/FISinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1480912026-05-29T13:59:51Z
dc.title.none.fl_str_mv Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
title Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
spellingShingle Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
Moreno-Franco, Belén
title_short Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
title_full Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
title_fullStr Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
title_full_unstemmed Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
title_sort Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study
dc.creator.none.fl_str_mv Moreno-Franco, Belén
Pérez-Esteban, Alejandro
Civeira, Fernando
Guallar-Castillón, Pilar
Casasnovas, José Antonio
Mateo-Gállego, Rocío
Jarauta, Estíbaliz
Malo, Sara
Laclaustra, Martín
author Moreno-Franco, Belén
author_facet Moreno-Franco, Belén
Pérez-Esteban, Alejandro
Civeira, Fernando
Guallar-Castillón, Pilar
Casasnovas, José Antonio
Mateo-Gállego, Rocío
Jarauta, Estíbaliz
Malo, Sara
Laclaustra, Martín
author_role author
author2 Pérez-Esteban, Alejandro
Civeira, Fernando
Guallar-Castillón, Pilar
Casasnovas, José Antonio
Mateo-Gállego, Rocío
Jarauta, Estíbaliz
Malo, Sara
Laclaustra, Martín
author2_role author
author
author
author
author
author
author
author
description Background and Aims: Many addictive substances, such as tobacco and alcohol, influence atherosclerosis development. Whether or not tobacco's pro-atherosclerotic effect is influenced by alcohol consumption is unknown. We aimed to estimate the impact of alcohol intake on the presence of subclinical atherosclerosis in femoral arteries in smoking and non-smoking middle-aged men.Design, Setting and Participants: Cross-sectional analysis of a subset of the Aragon Workers Health Study (AWHS), comprising 2099 men with mean age 50.9 years without previous cardiovascular disease. Measurements: The presence of plaques in femoral arteries was assessed by high-resolution sonography. Self-reported alcohol consumption over the previous year was measured with a food frequency questionnaire. The sample was divided into four groups according to their daily grams of alcohol consumption = 1 (abstainers), = 2 to < 30, = 30 to < 60 and = 60 g/day. Participants were divided on ever-smoking (current and former) versus never-smoking strata in the main analysis. Findings: We did not find a significant association between the different levels of alcohol intake and the likelihood of developing femoral artery atherosclerosis in never-smokers. Ever-smoking was positively associated with femoral atherosclerosis overall [odds ratio (OR) = 3.00; 95% confidence interval (CI) = 2.40, 3.74; P < 0.001] and within each level of alcohol consumption. Atherosclerosis was lower in ever-smokers who consumed 2 g/day or more but less than 30 g/day with respect to those ever-smokers who were abstainers (OR = 0.70; 95% CI = 0.49, 0.99; P < 0.05). However, among these ever-smokers, atherosclerosis prevalence was still higher than among never-smokers who consumed alcohol in the same amount (2 g/day or more but less than 30 g/day) (OR = 2.73; 95% CI = 2.07, 3.61; P < 0.001). Conclusions: Among middle-aged men, moderate alcohol consumption appears to be associated with lower prevalence of femoral artery subclinical atherosclerosis compared with alcohol abstinence only in ever-smokers.
publishDate 2020
dc.date.none.fl_str_mv 2020
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info:eu-repo/semantics/acceptedVersion
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/148091
url http://zaguan.unizar.es/record/148091
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/ISCIII/FIS
info:eu-repo/grantAgreement/ES/ISCIII/FIS
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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