Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study

This article belongs to the Special Issue Immunology of Neuropsychiatric Disorders.

Detalles Bibliográficos
Autores: Juncal Ruiz, María, Riesco-Dávila, Laura, Vázquez-Bourgon, Javier, Ortiz-Garcia de la Foz, Victor, Mayoral-van Son, Jacqueline, Ayesa Arriola, Rosa, Setién-Suero, Esther, Leza, Juan C., López-Hoyos, Marcos, Crespo-Facorro, Benedicto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/238676
Acceso en línea:http://hdl.handle.net/10261/238676
Access Level:acceso abierto
Palabra clave:Psychosis
Neuroinflammation
Toll-like receptors
Cytokines
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spelling Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month StudyJuncal Ruiz, MaríaRiesco-Dávila, LauraVázquez-Bourgon, JavierOrtiz-Garcia de la Foz, VictorMayoral-van Son, JacquelineAyesa Arriola, RosaSetién-Suero, EstherLeza, Juan C.López-Hoyos, MarcosCrespo-Facorro, BenedictoPsychosisNeuroinflammationToll-like receptorsCytokinesThis article belongs to the Special Issue Immunology of Neuropsychiatric Disorders.Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naïve first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1–9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1–9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We found a lower expression of these receptors in FEP individuals, regarding healthy volunteers at baseline and after 3-month of treatment on the three PBMCs subsets. Most TLRs showed a lower functionality (especially reduced intracellular levels of TNF-α) in patients than in healthy volunteers. These results, together with previous evidence, suggest that individuals with psychosis might show a pattern of TLR expression that differs from that of healthy volunteers, which could vary according to the intensity of immune/inflammatory response.Multidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/238676reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.3390/ijms21176106Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2386762026-05-22T06:33:51Z
dc.title.none.fl_str_mv Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
title Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
spellingShingle Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
Juncal Ruiz, María
Psychosis
Neuroinflammation
Toll-like receptors
Cytokines
title_short Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
title_full Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
title_fullStr Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
title_full_unstemmed Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
title_sort Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study
dc.creator.none.fl_str_mv Juncal Ruiz, María
Riesco-Dávila, Laura
Vázquez-Bourgon, Javier
Ortiz-Garcia de la Foz, Victor
Mayoral-van Son, Jacqueline
Ayesa Arriola, Rosa
Setién-Suero, Esther
Leza, Juan C.
López-Hoyos, Marcos
Crespo-Facorro, Benedicto
author Juncal Ruiz, María
author_facet Juncal Ruiz, María
Riesco-Dávila, Laura
Vázquez-Bourgon, Javier
Ortiz-Garcia de la Foz, Victor
Mayoral-van Son, Jacqueline
Ayesa Arriola, Rosa
Setién-Suero, Esther
Leza, Juan C.
López-Hoyos, Marcos
Crespo-Facorro, Benedicto
author_role author
author2 Riesco-Dávila, Laura
Vázquez-Bourgon, Javier
Ortiz-Garcia de la Foz, Victor
Mayoral-van Son, Jacqueline
Ayesa Arriola, Rosa
Setién-Suero, Esther
Leza, Juan C.
López-Hoyos, Marcos
Crespo-Facorro, Benedicto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Psychosis
Neuroinflammation
Toll-like receptors
Cytokines
topic Psychosis
Neuroinflammation
Toll-like receptors
Cytokines
description This article belongs to the Special Issue Immunology of Neuropsychiatric Disorders.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/238676
url http://hdl.handle.net/10261/238676
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.org/10.3390/ijms21176106
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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