Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system

Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. However, other neurochemical systems also...

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Detalles Bibliográficos
Autores: Berrendero Díaz, Fernando, 1971-, Robledo, Patricia, 1958-, Trigo i Rodríguez, Josep M., Martín García, Elena, 1975-, Maldonado, Rafael, 1961-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2010
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/36609
Acceso en línea:http://hdl.handle.net/10230/36609
http://dx.doi.org/10.1016/j.neubiorev.2010.02.006
Access Level:acceso abierto
Palabra clave:Addiction
Enkephalin
Dynorphin
Beta-endorphin
Tolerance
Withdrawal
Naltrexone
Opioid receptor
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spelling Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid systemBerrendero Díaz, Fernando, 1971-Robledo, Patricia, 1958-Trigo i Rodríguez, Josep M.Martín García, Elena, 1975-Maldonado, Rafael, 1961-AddictionEnkephalinDynorphinBeta-endorphinToleranceWithdrawalNaltrexoneOpioid receptorNicotine is the primary component of tobacco that maintains the smoking habit and develops addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. However, other neurochemical systems also participate in the addictive effects of nicotine including glutamate, cannabinoids, GABA and opioids. This review will cover the involvement of these neurotransmitters in nicotine addictive properties, with a special emphasis on the endogenous opioid system. Thus, endogenous enkephalins and beta-endorphins acting on mu-opioid receptors are involved in nicotine-rewarding effects, whereas opioid peptides derived from prodynorphin participate in nicotine aversive responses. An up-regulation of mu-opioid receptors has been reported after chronic nicotine treatment that could counteract the development of nicotine tolerance, whereas the down-regulation induced on kappa-opioid receptors seems to facilitate nicotine tolerance. Endogenous enkephalins acting on mu-opioid receptors also play a role in the development of physical dependence to nicotine. In agreement with these actions of the endogenous opioid system, the opioid antagonist naltrexone has shown to be effective for smoking cessation in certain sub-populations of smokers.This work was supported by the Spanish “Ministerio de Ciencia e Innovación” (#SAF2007-64062) and “Instituto de Salud Carlos III” (#RD06/001/001, PI070709 and PI070559), the Catalan Government (SGR2009-00131), the ICREA Foundation (ICREA Academia-2008), NIDA (1R01-DA01 6768-0111) and the DG Research of the European Commission (NEWMOOD LSHM-CT-2004-503474; GENADDICT, #LSHM-CT-2004-05166; and PHECOMP, #LSHM-CT-2007-037669). J.M.T and E.M.G. are post-doctoral fellows of Instituto de Salud Carlos III “Contratos posdoctorales de perfeccionamiento Sara Borrell”.Elsevier201920192010info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/36609http://dx.doi.org/10.1016/j.neubiorev.2010.02.006reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeurosci Biobehav Rev. 2010; 35(2):220-31info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062© Elsevier http://dx.doi.org/10.1016/j.neubiorev.2010.02.006info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/366092026-06-12T07:21:37Z
dc.title.none.fl_str_mv Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
title Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
spellingShingle Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
Berrendero Díaz, Fernando, 1971-
Addiction
Enkephalin
Dynorphin
Beta-endorphin
Tolerance
Withdrawal
Naltrexone
Opioid receptor
title_short Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
title_full Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
title_fullStr Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
title_full_unstemmed Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
title_sort Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
dc.creator.none.fl_str_mv Berrendero Díaz, Fernando, 1971-
Robledo, Patricia, 1958-
Trigo i Rodríguez, Josep M.
Martín García, Elena, 1975-
Maldonado, Rafael, 1961-
author Berrendero Díaz, Fernando, 1971-
author_facet Berrendero Díaz, Fernando, 1971-
Robledo, Patricia, 1958-
Trigo i Rodríguez, Josep M.
Martín García, Elena, 1975-
Maldonado, Rafael, 1961-
author_role author
author2 Robledo, Patricia, 1958-
Trigo i Rodríguez, Josep M.
Martín García, Elena, 1975-
Maldonado, Rafael, 1961-
author2_role author
author
author
author
dc.subject.none.fl_str_mv Addiction
Enkephalin
Dynorphin
Beta-endorphin
Tolerance
Withdrawal
Naltrexone
Opioid receptor
topic Addiction
Enkephalin
Dynorphin
Beta-endorphin
Tolerance
Withdrawal
Naltrexone
Opioid receptor
description Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. However, other neurochemical systems also participate in the addictive effects of nicotine including glutamate, cannabinoids, GABA and opioids. This review will cover the involvement of these neurotransmitters in nicotine addictive properties, with a special emphasis on the endogenous opioid system. Thus, endogenous enkephalins and beta-endorphins acting on mu-opioid receptors are involved in nicotine-rewarding effects, whereas opioid peptides derived from prodynorphin participate in nicotine aversive responses. An up-regulation of mu-opioid receptors has been reported after chronic nicotine treatment that could counteract the development of nicotine tolerance, whereas the down-regulation induced on kappa-opioid receptors seems to facilitate nicotine tolerance. Endogenous enkephalins acting on mu-opioid receptors also play a role in the development of physical dependence to nicotine. In agreement with these actions of the endogenous opioid system, the opioid antagonist naltrexone has shown to be effective for smoking cessation in certain sub-populations of smokers.
publishDate 2010
dc.date.none.fl_str_mv 2010
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/36609
http://dx.doi.org/10.1016/j.neubiorev.2010.02.006
url http://hdl.handle.net/10230/36609
http://dx.doi.org/10.1016/j.neubiorev.2010.02.006
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neurosci Biobehav Rev. 2010; 35(2):220-31
info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.neubiorev.2010.02.006
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.neubiorev.2010.02.006
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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