Eradication of hepatitis C virus and non-liver-related non–acquired immune deficiency syndrome–related events in human immunodeficiency virus/hepatitis C virus coinfection

We assessed non-liver-related non–acquired immunodeficiency syndrome (AIDS)-related (NLR-NAR) events and mortalityin a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–coinfected patients treated with interferon(IFN) and ribavirin (RBV), between 2000 and 2008. The censoring date wa...

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Detalles Bibliográficos
Autores: Berenguer, Juan, Rodríguez-Castellano, Elena, Carrero, Ana, Von Wichmann, Miguel A., Montero, Marta, Galindo, María J., Mallolas, Josep, Crespo, Manuel, Téllez, María J., Quereda, Carmen, Sanz, José, Barros, Carlos, Tural, Cristina, Santos, Ignacio, Pulido, Federico, Guardiola Tey, Josep Maria, Rubio, Rafael, Ortega, Enrique, Montes, María L., Jusdado, Juan J., Gaspar, Gabriel, Esteban, Herminia, Bellón, José M., González-García, Juan, GESIDA HIV-HCV Cohort Study Group
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/2629
Acceso en línea:http://hdl.handle.net/20.500.12328/2629
https://dx.doi.org/10.1002/hep.29071
Access Level:acceso abierto
Palabra clave:Síndrome d’immunodeficiència no adquirida
SIDA
Fetge
Mortalitat
Virus de la Immunodeficiència Humana
VIH
Hepatitis C
VHC
Síndrome de inmunodeficiencia no adquirida
Hígado
Mortalidad
Virus de la Inmunodeficiencia Humana
Non–acquired immunodeficiency syndrome
Liver
Mortality
Human Immunodeficiency Virus
61
616.9
Descripción
Sumario:We assessed non-liver-related non–acquired immunodeficiency syndrome (AIDS)-related (NLR-NAR) events and mortalityin a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–coinfected patients treated with interferon(IFN) and ribavirin (RBV), between 2000 and 2008. The censoring date was May 31, 2014. Cox regression analysis was per-formed to assess the adjusted hazard rate (HR) of overall death in responders and nonresponders. Fine and Gray regressionanalysis was conducted to determine the adjusted subhazard rate (sHR) of NLR deaths and NLR-NAR events consideringdeath as the competing risk. The NLR-NAR events analyzed included diabetes mellitus, chronic renal failure, cardiovascularevents, NLR-NAR cancer, bone events, and non-AIDS-related infections. The variables for adjustment were age, sex, pastAIDS, HIV transmission category, nadir CD41T-cell count, antiretroviral therapy, HIV RNA, liver fibrosis, HCV genotype,and exposure to specific anti-HIV drugs. Of the 1,625 patients included, 592 (36%) had a sustained viral response (SVR). Aftera median 5-year follow-up, SVR was found to be associated with a significant decrease in the hazard of diabetes mellitus (sHR,0.57; 95% confidence interval [CI], 0.35-0.93; P 5 0.024) and decline in the hazard of chronic renal failure close to the thresh-old of significance (sHR, 0.43; 95% CI, 0.17-1.09; P 5 0.075). Conclusion: Our data suggest that eradication of HCV in coin-fected patients is associated not only with a reduction in the frequency of death, HIV progression, and liver-related events, butalso with a reduced hazard of diabetes mellitus and possibly of chronic renal failure. These findings argue for the prescription ofHCV therapy in coinfected patients regardless of fibrosis stage.

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