The Role of the Ubiquitin System in Eye Diseases

The ubiquitin-proteasome system (UPS) is a fundamental process that regulates various biological functions, including immune response, cell cycle, oxidative stress, migration, and cellular proliferation. This system is responsible for the degradation of proteins, while proteasomes play a significant...

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Detalles Bibliográficos
Autores: Durán-Cristiano, Sandra Carolina, De Diego García, Laura, Martín Gil, Alba, Carracedo Rodríguez, Juan Gonzalo
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/119716
Acceso en línea:https://hdl.handle.net/20.500.14352/119716
Access Level:acceso abierto
Palabra clave:617.7
Immunoproteasome
Ocular surface
Proteasome
Retinal diseases
Ubiquitin
Oftalmología
3201.09 Oftalmología
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spelling The Role of the Ubiquitin System in Eye DiseasesDurán-Cristiano, Sandra CarolinaDe Diego García, LauraMartín Gil, AlbaCarracedo Rodríguez, Juan Gonzalo617.7ImmunoproteasomeOcular surfaceProteasomeRetinal diseasesUbiquitinOftalmología3201.09 OftalmologíaThe ubiquitin-proteasome system (UPS) is a fundamental process that regulates various biological functions, including immune response, cell cycle, oxidative stress, migration, and cellular proliferation. This system is responsible for the degradation of proteins, while proteasomes play a significant role in mechanisms involved in health and human diseases. The participation of the UPS in immune response is particularly relevant, leading to the involvement of immunoproteasomes. This specialized proteasome is involved in the processing and presentation of antigenic peptides, making it crucial for proper immune function. Moreover, the impact of the UPS is considered essential in understanding several diseases, such as neurodegenerative disorders, infections, and vascular diseases. The dysregulation of the UPS may contribute to the pathogenesis of these conditions, highlighting its importance as a potential therapeutic target. Interestingly, the UPS is also related to ocular structures, playing a role in visual perception and ocular homeostasis. This involvement in the regulation of various ocular processes suggests its potential impact on both anterior and posterior eye pathologies. This review aims to discuss the general considerations of the UPS and provide information about its participation in anterior and posterior eye pathologies. By understanding its role in ocular health and disease, researchers and clinicians may explore novel therapeutic strategies targeting the UPS for the treatment of various eye conditions. In conclusion, the UPS is a crucial player in biological processes, with far-reaching implications in health and disease, including the anterior and posterior segments of the eye. Further research in this field may lead to the development of innovative therapies and a better understanding of the complex mechanisms underlying various eye disorders.PubMedUniversidad Complutense de Madrid20252025-03-2020252025-03-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/119716reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1197162026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Role of the Ubiquitin System in Eye Diseases
title The Role of the Ubiquitin System in Eye Diseases
spellingShingle The Role of the Ubiquitin System in Eye Diseases
Durán-Cristiano, Sandra Carolina
617.7
Immunoproteasome
Ocular surface
Proteasome
Retinal diseases
Ubiquitin
Oftalmología
3201.09 Oftalmología
title_short The Role of the Ubiquitin System in Eye Diseases
title_full The Role of the Ubiquitin System in Eye Diseases
title_fullStr The Role of the Ubiquitin System in Eye Diseases
title_full_unstemmed The Role of the Ubiquitin System in Eye Diseases
title_sort The Role of the Ubiquitin System in Eye Diseases
dc.creator.none.fl_str_mv Durán-Cristiano, Sandra Carolina
De Diego García, Laura
Martín Gil, Alba
Carracedo Rodríguez, Juan Gonzalo
author Durán-Cristiano, Sandra Carolina
author_facet Durán-Cristiano, Sandra Carolina
De Diego García, Laura
Martín Gil, Alba
Carracedo Rodríguez, Juan Gonzalo
author_role author
author2 De Diego García, Laura
Martín Gil, Alba
Carracedo Rodríguez, Juan Gonzalo
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 617.7
Immunoproteasome
Ocular surface
Proteasome
Retinal diseases
Ubiquitin
Oftalmología
3201.09 Oftalmología
topic 617.7
Immunoproteasome
Ocular surface
Proteasome
Retinal diseases
Ubiquitin
Oftalmología
3201.09 Oftalmología
description The ubiquitin-proteasome system (UPS) is a fundamental process that regulates various biological functions, including immune response, cell cycle, oxidative stress, migration, and cellular proliferation. This system is responsible for the degradation of proteins, while proteasomes play a significant role in mechanisms involved in health and human diseases. The participation of the UPS in immune response is particularly relevant, leading to the involvement of immunoproteasomes. This specialized proteasome is involved in the processing and presentation of antigenic peptides, making it crucial for proper immune function. Moreover, the impact of the UPS is considered essential in understanding several diseases, such as neurodegenerative disorders, infections, and vascular diseases. The dysregulation of the UPS may contribute to the pathogenesis of these conditions, highlighting its importance as a potential therapeutic target. Interestingly, the UPS is also related to ocular structures, playing a role in visual perception and ocular homeostasis. This involvement in the regulation of various ocular processes suggests its potential impact on both anterior and posterior eye pathologies. This review aims to discuss the general considerations of the UPS and provide information about its participation in anterior and posterior eye pathologies. By understanding its role in ocular health and disease, researchers and clinicians may explore novel therapeutic strategies targeting the UPS for the treatment of various eye conditions. In conclusion, the UPS is a crucial player in biological processes, with far-reaching implications in health and disease, including the anterior and posterior segments of the eye. Further research in this field may lead to the development of innovative therapies and a better understanding of the complex mechanisms underlying various eye disorders.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-03-20
2025
2025-03-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/119716
url https://hdl.handle.net/20.500.14352/119716
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PubMed
publisher.none.fl_str_mv PubMed
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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