In situ formation of magnetopolymersomes via electroporation for MRI<br />

As the development of diagnostic/therapeutic (and combined: theranostic) nanomedicine grows, smart drug-delivery vehicles become ever more critical. Currently therapies consist of drugs tethered to, or encapsulated within nanoparticles or vesicles. There is growing interest in functionalising them w...

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Autores: Bain, Jennifer, Ruiz-Perez, Lorena, Kennerley, Aneurin J., Muench, Stephen, Thompson, Rebecca, Battaglia, Giuseppe, Staniland, Sarah S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222258
Acceso en línea:https://hdl.handle.net/2445/222258
Access Level:acceso abierto
Palabra clave:Bioelectroquímica
Electroporació
Nanopartícules
Bioelectrochemistry
Electroporation
Nanoparticles
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spelling In situ formation of magnetopolymersomes via electroporation for MRI<br />Bain, JenniferRuiz-Perez, LorenaKennerley, Aneurin J.Muench, StephenThompson, RebeccaBattaglia, GiuseppeStaniland, Sarah S.BioelectroquímicaElectroporacióNanopartículesBioelectrochemistryElectroporationNanoparticlesAs the development of diagnostic/therapeutic (and combined: theranostic) nanomedicine grows, smart drug-delivery vehicles become ever more critical. Currently therapies consist of drugs tethered to, or encapsulated within nanoparticles or vesicles. There is growing interest in functionalising them with magnetic nanoparticles (MNPs) to target the therapeutics by localising them using magnetic fields. An alternating magnetic field induces remote heating of the particles (hyperthermia) triggering drug release or cell death. Furthermore, MNPs are diagnostic MRI contrast agents. There is considerable interest in MNP embedded vehicles for nanomedicine, but their development is hindered by difficulties producing consistently monodisperse MNPs and their reliable loading into vesicles. Furthermore, it is highly advantageous to "trigger" MNP production and to tune the MNP's size and magnetic response. Here we present the first example of a tuneable, switchable magnetic delivery vehicle for nanomedical application. These are comprised of robust, tailored polymer vesicles (polymersomes) embedded with superparamagnetic magnetite MNPs (magnetopolymersomes) which show good MRI contrast (R2* = 148.8 s−1) and have a vacant core for loading of therapeutics. Critically, the magnetopolymersomes are produced by a pioneering nanoreactor method whereby electroporation triggers the <em>in situ</em> formation of MNPs within the vesicle membrane, offering a switchable, tuneable magnetic responsive theranostic delivery vehicle.Nature Publishing Group2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222258Articles publicats en revistes (Física Aplicada)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/srep14311Scientific Reports, 2015https://doi.org/10.1038/srep14311cc-by (c) Bain, J. et al., 2015http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2222582026-05-27T06:46:51Z
dc.title.none.fl_str_mv In situ formation of magnetopolymersomes via electroporation for MRI<br />
title In situ formation of magnetopolymersomes via electroporation for MRI<br />
spellingShingle In situ formation of magnetopolymersomes via electroporation for MRI<br />
Bain, Jennifer
Bioelectroquímica
Electroporació
Nanopartícules
Bioelectrochemistry
Electroporation
Nanoparticles
title_short In situ formation of magnetopolymersomes via electroporation for MRI<br />
title_full In situ formation of magnetopolymersomes via electroporation for MRI<br />
title_fullStr In situ formation of magnetopolymersomes via electroporation for MRI<br />
title_full_unstemmed In situ formation of magnetopolymersomes via electroporation for MRI<br />
title_sort In situ formation of magnetopolymersomes via electroporation for MRI<br />
dc.creator.none.fl_str_mv Bain, Jennifer
Ruiz-Perez, Lorena
Kennerley, Aneurin J.
Muench, Stephen
Thompson, Rebecca
Battaglia, Giuseppe
Staniland, Sarah S.
author Bain, Jennifer
author_facet Bain, Jennifer
Ruiz-Perez, Lorena
Kennerley, Aneurin J.
Muench, Stephen
Thompson, Rebecca
Battaglia, Giuseppe
Staniland, Sarah S.
author_role author
author2 Ruiz-Perez, Lorena
Kennerley, Aneurin J.
Muench, Stephen
Thompson, Rebecca
Battaglia, Giuseppe
Staniland, Sarah S.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioelectroquímica
Electroporació
Nanopartícules
Bioelectrochemistry
Electroporation
Nanoparticles
topic Bioelectroquímica
Electroporació
Nanopartícules
Bioelectrochemistry
Electroporation
Nanoparticles
description As the development of diagnostic/therapeutic (and combined: theranostic) nanomedicine grows, smart drug-delivery vehicles become ever more critical. Currently therapies consist of drugs tethered to, or encapsulated within nanoparticles or vesicles. There is growing interest in functionalising them with magnetic nanoparticles (MNPs) to target the therapeutics by localising them using magnetic fields. An alternating magnetic field induces remote heating of the particles (hyperthermia) triggering drug release or cell death. Furthermore, MNPs are diagnostic MRI contrast agents. There is considerable interest in MNP embedded vehicles for nanomedicine, but their development is hindered by difficulties producing consistently monodisperse MNPs and their reliable loading into vesicles. Furthermore, it is highly advantageous to "trigger" MNP production and to tune the MNP's size and magnetic response. Here we present the first example of a tuneable, switchable magnetic delivery vehicle for nanomedical application. These are comprised of robust, tailored polymer vesicles (polymersomes) embedded with superparamagnetic magnetite MNPs (magnetopolymersomes) which show good MRI contrast (R2* = 148.8 s−1) and have a vacant core for loading of therapeutics. Critically, the magnetopolymersomes are produced by a pioneering nanoreactor method whereby electroporation triggers the <em>in situ</em> formation of MNPs within the vesicle membrane, offering a switchable, tuneable magnetic responsive theranostic delivery vehicle.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222258
url https://hdl.handle.net/2445/222258
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/srep14311
Scientific Reports, 2015
https://doi.org/10.1038/srep14311
dc.rights.none.fl_str_mv cc-by (c) Bain, J. et al., 2015
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bain, J. et al., 2015
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Física Aplicada)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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